教育经历

2001-2008 美国得克萨斯大学MD安德森肿瘤中心，UTHealth生物医学研究生院，博士，专业：细胞与生化

1997-2001 武汉大学生命科学学院，理学学士，专业：微生物学

工作经历

2008-2011 美国得克萨斯大学 MD安德森肿瘤中心，博士后

2011-2013 武汉大学生命科学学院病毒学系，副教授，博导

2012-至今 病毒学国家重点实验室 固定成员（PI）

2013-2017 武汉大学生命科学学院病毒学系，“珞珈学者”特聘教授、副系主任、博导

2017-至今 中国科学院武汉病毒研究所，研究员、博导

2018-至今 病毒学国家重点实验室，副主任

2022-至今 中国科学院武汉病毒研究所，副所长

学术兼职

2018-至今 湖北省微生物学会，副理事长

2020-中国科学技术大学，博士生导师

2021-中国微生物学会理事/病毒学专委会

研究内容

致力于申请人长期致力于RNA病毒与宿主相互作用的分子机制研究，从分子层面阐明多种重要RNA病毒的复制 、致病及宿主抗病毒免疫的基本规律，并根据发现的靶点研发新型干预策略，为重要 RNA病毒的防治提供了生物学基础 。

主持项目

1. 国家自然科学基金（国家杰出青年基金）

课题名称：RNA病毒与宿主相互作用（项目编号：32225004）

执行年限：2023-2027

承担角色：项目负责人

资助金额：400万元

2. 国家自然科学基金（联合基金项目重点支持项目）

课题名称：靶向病毒RNAi抑制子的抗病毒药物临床前研究（项目编号：U21A20423）

执行年限：2022-2025

承担角色：项目负责人

资助金额：338万元

3. 国家重点研发计划

课题名称：新发突发病毒复制蛋白机器与广谱药物靶点研究（项目编号：2021YFC2300700）

执行年限：2021-2024

承担角色：课题负责人

资助金额：200万元

4. 中国科学院国际合作局国际伙伴计划

课题名称：瓜环纳米囊抗病毒活性及瓜环纳米囊负载抗病毒药物研究（项目编号：153B42KYSB20200004）

执行年限：2021-2023

承担角色：项目负责人

资助金额：100万元

5. 国家自然科学基金（面上项目）

课题名称：Dicer调控TLR3抗病毒免疫通路的机制研究（项目编号：31970169）

执行年限：2016-2018

承担角色：项目负责人

资助金额：20万元

6. 中国科学院战略性先导科技专项（B类）

课题名称：病毒与宿主相互作用机制（项目编号：XDB29010300）

执行年限：2018-2023

承担角色：课题负责人

资助金额：1513.05万元

成果

1. Kong J, Bie Y, Ji W, Xu J, Lyu B, Xiong X, Qiu Y*, Zhou X*.(2023) Alphavirus infection triggers antiviral RNAi immunity in mammals. Cell Reports. 42(5):112441.

2. Ren Y, Wang A, Wu D, Wang C, Huang M, Xiong X, Jin L, Zhou W*, Qiu Y*, Zhou X*.(2022) Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables efficient virus replication. Nature Microbiology. 7, 1041–1053

3. Xu X-Q, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X*, Lin S-H*, Qiu Y*. (2022) Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis. mBio. e0237022

4. Wang C, Yang R, Yang F, Han Y, Ren Y, Xiong X, Wang X, Bi Y, Li L, Qiu Y*, Yi Xu*, Zhou X*. (2022)   Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation. PLoS Pathogens. 18(8):e1010787.

5. Wu D, Wang Z, Zhang J, Adam G.R, Lyu B, Chen Z, Wang C, Wei B, Xia X, Zhang Q, Zhou X*. (2022) Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies. Cell Death Dis. 13(8):731.

6. Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D-Y, Zhou X*, Cai Z*, Shang Y*, Lin S-H*. (2022) Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients. PNAS. 119(34):e2117089119.

7. Chen Z, Xiong X, Li Y, Huang M, Ren Y, Wu D, Qiu Y, Chen M*, Shu T*, Zhou X* (2022) The nonstructural protein 2C of Coxsackie B virus has RNA helicase and chaperoning activities. Virol Sin. 37(5):656-663.

8. Lyu B, Wang C, Bie Y, Kong J, Wang A, Jin L, Qiu Y*, Zhou X*. (2022) Enoxacin shows a broad-spectrum antiviral activity against diverse viruses by enhancing antiviral RNAi in insects. J Virol. 96(4):e0177821.

9. Fang Y, Liu Z, Qiu Y, Kong J, Fu Y, Liu Y, Wang C, Quan J, Wang Q, Xu W, Yin L, Cui J, Xu Y, Curry S, Jiang S, Lu L* and Zhou X*. (2021) Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 54(10): 2231-2244.e6

10. Qiu Y, Wu D, Ning W, Xu J, Shu T, Huang M, Chen R, Zhang J, Han Y, Yang Q, Li R, Yang X, Wang Y, Zou X, Pan S, Huang C*, Xue Y*, Shang Y* and Zhou X*. (2021) Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19. National Science Review. 8(11):nwab143.

11. Ren Y, Wang A, Fang Y, Shu T, Wu D, Wang C, Huang M, Min J, Jin L, Zhou W*, Qiu Y* and Zhou X*. (2021) SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells. Frontiers in Cellular and Infection Microbiology. doi: 10.3389/fcimb.2021.706252.

12. Fang Y, Wang C, Wang C, Yang R, Bai P, Zhang X-Y, Kong J, Yin L, Qiu Y, Zhou X*. (2021) Antiviral peptides targeting the helicase activity of enterovirus nonstructural protein 2C. J Virol. 95: e02324-20.

13. Wang C, Li X, Ning W, Gong S, Yang F, Fang C, Gong Y, Wu D, Huang M, Gou Y, Fu S, Ren Y, Yang R, Qiu Y*, Xue Y*, Xu Y* and Zhou X*. (2021) Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19. Theranostics. 11(16): 8008-8026.

14. Quan J, Zhang X, Ding Y, Li S, Qiu Y, Wang R* and Zhou X*. (2021) Cucurbit[7]uril as a Broad-Spectrum Antiviral Agent against Diverse RNA Viruses. Virol Sin. doi: 10.1007/s12250-021-00404-9.

15. Zhang X, Shu T, Wang X, Qiu Y and Zhou X*. (2021) Guaico Culex virus NSP2 has RNA helicase and chaperoning activities. J Gen Virol, 102(4).

16. Han Y, Liu P, Qiu Y, Zhou J, Liu Y, Hu X, Yang Q, Huang R, Wen X, Song H, Yu P, Yang M, Zhang J, Liu W.J , Peng K, Wu G*, Zhang D*, Zhou X* and Wu Y*(2021). Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19. JCI Insight, 6(4):e146267.

17. Xu J, Kong J, Lyu B, Wang X 1,2, Qian Q, Zhou X* and Qiu Y*(2021). The Capsid Protein of Rubella Virus Antagonizes RNA Interference in Mammalian Cells. Viruses, 13(2):154.

18. Shu T, Ning W, Wu D, Xu J, Han Q, Huang M, Zou X, Yang Q, Yuan Y, Bie Y, Pan S, Mu J, Han Y, Yang X, Zhou H, Li R, Ren Y, Chen X, Yao S, Qiu Y*, Zhang DY*, Xue Y*, Shang Y* and Zhou X*. (2020) Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19. Immunity. 53(5):1108-1122.e5.

19. Wang C, Xu J, Wang S, Pan S, Zhang J, Han Y, Huang M, Wu D, Yang Q, Yang X, Yang Y, Shu T, Zou X, Li R, Luo Y, Yao R, Wang Y, Qiu Y, Wang Y, Zhang D-Y, Yao Q*, Yan Y*, Zhou X* and Shang Y*(2020) Imaging Mass Cytometric Analysis of Postmortem Tissues Reveals Dysregulated Immune Cell and Cytokine Responses in Multiple Organs of COVID-19 Patients. Frontiers in Microbiology. doi:10.3389/fmicb.2020.600989

20. Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L, Lin S-H* and Zhou X* (2020) Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19. Signal Transduction &Targeted Therapy23;5(1):247

21. Mu J, Fang Y, Yang Qi, Shu T, Wang A, Huang M, Jin L, Deng F, Qiu Y* and Zhou X*. (2020) SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2. Cell Discovery. 6:65

22. Han Y, Yang Q, Liu Y, Shu T, Yue L, Xiao T, Zeng Q, Wu Y, Zhou X* and Zhang DY*. (2020) Feasibility Study of Mixing Throat Swab Samples for Severe Acute Respiratory Syndrome Coronavirus-2 Screening. Virol Sin. 35(6):830-832.

23. Wu D, Shu T, Yang X, Song J-X, Zhang M,Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin S-H*, Qiu Y*, Zhang D-Y*, Shang Y* and Zhou X*.(2020) Plasma metabolomic and lipidomic alterations associated with COVID-19.National Science Review. 7: 1157–1168

24. Shu T, Huang M, Wu D, Ren Y, Zhang X, Han Y, Mu J, Wang R, Qiu Y, Zhang D-Y* and Zhou X*. (2020) SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts. Virologica Sinica.35(3):321-329.

25. Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, Han Y, Zhang X, Zhou W, Qiu Y and Zhou X*.(2020) The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Cellular & Molecular Immunology 17(8):881-883.

26. Mu J, Zhang H, Li T, Shu T, Qiu Y and Zhou X*. (2020) The 3A protein of coxsackievirus B3 acts as a viral suppressor of RNA interference. J Gen Virol, 101(10):1069-1078.

27. Mu J, Xu J, Zhang L, Shu T, Wu D, Huang M, Ren Y, Li X, Geng Q, Xu Y, Qiu Y* and Zhou X*. (2020) SARS-CoV-2-encoded Nucleocapsid Protein Acts as a Viral Suppressor of RNA interference in Cells. Science China Life Sciences, 63(9):1-4

28. Qiu Y, Xu Y-P, Wang M, Miao M, Zhou H, Xu J, Kong J, Zheng D, Li R-T, Zhang R-R, Guo Y, Li X-F, Cui J, Qin C-F* and Zhou X*. (2020) Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes. Science Advances 6: eaax7989.

29. Qian Q, Zhou H, Shu T, Mu J, Fang Y, Xu J, Li T, Kong J, Qiu Y* and Zhou X*. (2020) The Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells. J Virol. 94(3): e01233-19 (J Virol Spotlight Article)

30. XuY-P, Qiu Y, Zhang B, Chen G, Chen Q, Wang M, Mo F, Xu J, Wu J, Zhang R-R, Cheng M-L, Zhang N-N, Lyu B, Zhu W-L, Wu M-H, Ye Q, Zhang D, Man J-H, Li X-F, Cui J, Xu Z, Hu B*, Zhou X* and Qin C-F*. (2019) Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids. Cell Res.29: 265-273. (Cover story)

31. Shu T, Gan T, Bai P, Wang X, Qian Q, Zhou H, Cheng Q, Qiu Y, Yin L, Zhong J and Zhou X*. (2019) Ebola Virus VP35 Has Novel NTPase and Helicase-like Activities. Nucleic Acids Res.47(11): 5837–5851.

32. Zhou H, Qian Q, Shu T, Xu J, Kong J, Mu J, Qiu Y* and Zhou X*. Hepatitis C Virus NS2 Protein Suppresses RNA Interference in Cells. Virol. Sin 35(4):436-444.

33. Miao M, Yu F, Wang D, Tong Y, Yang L, Xu J, Qiu Y, Zhou X* and Zhao X*. (2019) Proteomics Profiling of Host Cell Response via Protein Expression and Phosphorylation upon Dengue Virus Infection. Virol. Sin. 34: 549–562.

34. Qiu Y and Zhou X*. (2018) STING: From Mammals to Insects. Cell Host Microbe. 24(1): 5-7.

35. Li T-F, Hosmillo M, Schwanke H, Shu T, Wang Z, Yin L, Curry S, Goodfellow IG and Zhou X*. (2018) Human Norovirus NS3 has RNA Helicase and Chaperoning Activities. J Virol. 92(5): e01606-17

36. Wang Z, Xia X, Yang X, Zhang X, Liu Y, Wu D, Fang Y, Liu Y, Qiu Y and Zhou X*. (2017) A Picorna-like Virus Suppresses the N-end Rule Pathway to Inhibit Apoptosis. eLife 6: e30590

37. Qiu Y, Xu Y, Zhang Y, Zhou H, Deng Y-Q, Li X-F, Miao M, Zhang Q, Zhong B, Hu Y, Zhang F-C, Wu L, Qin C-F* and Zhou X*. (2017) Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals. Immunity 46(6): 992–1004.

38. Wang Z, Wu D, Liu Y, Xia X, Gong W, Qiu Y, Yang J, Zheng Y, Li J, Wang YF, Xiang Y, Hu Y and Zhou X*. (2015) Drosophila Dicer-2 has an RNA interference-independent Function that Modulates Toll Immune Signaling. Science Advances 1: e1500228.

39. Xia H, Wang P, Wang GC, Yang J, Sun X, Wu W, Qiu Y, Shu T, Zhao X, Yin L, Qin CF, Hu Y and Zhou X*. (2015) Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-independent RNA Chaperone. PLoS Pathogens 11(7): e1005067.

40. Yang J, Cheng Z, Zhang S, Xiong W, Xia H, Qiu Y, Wang Z, Wu F, Qin CF, Yin L, Hu Y and Zhou X* (2014) A Cypovirus VP5 Displays the RNA Chaperone-like Activity that Destabilizes RNA Helices and Accelerates Strand Annealing. Nucleic Acids Res. 42(4): 2538-2554.

奖励

2022 国家杰出青年科学基金

2020 中国科学院优秀共产党员

2017 英国皇家学会“牛顿高级学者”（Newton Advanced Fellow）

2015 国家优秀青年科学基金