Wei Li, Jingyi Yang, Ejuan Zhang, Maohua Zhong, Yang Xiao, Jie Yu, DihanZhou, Yuan Cao, Yi Yang, Yaoming Li and HuiminYan. Activation of NLRC4 downregulates TLR5-mediated antibody immuneresponses against flagellin. Cell Mol Immunol. 2016, 13:514-523. doi:10.1038/cmi.2015.33
Rong Bao,Jingyi Yang, Ying Sun, Dihan Zhou, Yi Yang, Yaoming Li, Yuan Cao, Yang Xiao, Wei Li, Jie Yu, Bali Zhao, Maohua Zhong, Huimin Yan.Flagellin-PAc Fusion Protein Inhibits Progression of Established Caries. JDent Res. 2015.94: 955-960, firstpublished on April 16, 2015 as doi:10.1177/0022034515582224
Yang Xiao, Fang Liu, Jingyi Yang, Maohua Zhong,Ejuan Zhang, Yaoming Li, Dihan Zhou, Yuan Cao, Wei Li, Jie Yu, Yi Yang and Huimin Yan.Over-activation of TLR5 signaling by high-dose flagellin induces liver injuryin mice. Cell Mol Immunol. 2015.12:730–743
Jingyi Yang, Ejuan Zhang, Fang Liu, Yan Zhang, Maohua Zhong, Yaoming Li,Dihan Zhou, Yaoqing Chen, Yuan Cao, Yang Xiao, Benxia He, Yi Yang, Ying Sun,Mengji Lu, Huimin Yan. Flagellins ofSalmonella Typhi and non-pathogenic Escherichia coli are differentiallyrecognized through NLRC4 pathway in macrophages. Journal of Innate Immunity.2014. 6:47-57
Huimin Yan. SalivaryIgA enhancement strategy for development of a nasal-spray anti-caries mucosalvaccine. Sci China Life Sci. 2013. 56(5):406-413.
Jingyi Yang, Maohua Zhong, Yan Zhang, Ejuan Zhang, Ying Sun, Yuan Cao, YaomingLi, Dihan Zhou, Benxia He, Yaoqing Chen, Yi Yang, Jie Yu, Huimin Yan. Antigen replacement of domains D2 and D3 in flagellinpromotes mucosal IgA production and attenuates flagellin-induced inflammatoryresponse after intranasal immunization. Human Vaccines & Immunotherapeutics,2013. 9(5): 1084-1092.
Ying Sun, Wei Shi , Jingyi Yang, Dihan Zhou, Yaoqing Chen, Yan Zhang, YiYang, Benxia He, Maohua Zhong, Yaoming Li, Yuan Cao, Yang Xiao, Wei Li, Jie Yu,Yuhong Li, Mingwen Fan, Huimin Yan. Flagellin-PAcFusion Protein Is a High Efficacy Anti-caries Mucosal Vaccine. JDent Res. 2012. 91(10): 941-947
Maohua Zhong, Benxia He, Jingyi Yang, Rong Bao, Yan Zhang, Dihan Zhou, YaoqingChen, Liangzhu Li, Chen Han, Yi Yang, Ying Sun, Yuan Cao, Yaoming Li, Wei Shi, ShiboJiang, Xiaoyan Zhang, Huimin Yan.L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammationfor Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide. AntimicrobAgents Chemother, 2012. 56(6):3121-3132
Wei Shi, Yuhong Li, Fang Liu, Jingyi Yang, Dihan Zhou, Yaoqing Chen,Yan Zhang, Yi Yang,Benxia He, Chen Han, Mingwen Fan, HuiminYan. Flagellin enhances saliva IgA response and protection of anti-cariesDNA vaccine. J Dent Res. 2012. 91(3):249-54
Dihan Zhou, Yan Zhang, Qiaoli Li,Yaoqing Chen, Benxia He, Jingyi Yang, Haobo Tu, Lei Lei, and Huimin Yan. Matrix protein-specific IgAantibody inhibits measles virus replication by intracellular neutralization. J.Virol. 2011. 85(21):11090-7.
授权专利
1. US8,449,891 B2. Recombinant Flagellin Protein and Preparation and Use Thereof.
Huimin YAN, Fang LIU, Jingyi YANG. (美国)Date of Patent:May 28, 2013
2. ZL200910194284.1 Recombinant Flagellin Protein and Preparation and Use Thereof.(一种改造的鞭毛素蛋白及其制备方法和应用。)China(中国)Huimin YAN, Fang LIU, Jingyi YANG。(鄢慧民,刘芳,杨菁毅)。Date of Patent: July 24, 2013
3. ZL200910194285.6. A kind of optimized mucosal adjuvant based on non-pathogenic E.coli-derived flagellin(一种改造的非致病细菌来源的鞭毛素黏膜佐剂及制备方法。)China (中国)Huimin YAN, Jingyi YANG, Fang LIU。(鄢慧民,杨菁毅,刘芳)。Date of Patent: March 13, 2013
4. ZL201110062300.9. (评价作用于体内黏膜的药物和外源物安全性的方法和应用。)China (中国)Huimin YAN, Maohua ZHONG, BenxiaHE。(鄢慧民,钟茂华,何本霞)。Date of Patent: September 4, 2013
5. ZL201110438088.1. VACCINE FOR DENTAL CARIES AND METHODS FOR PREPARING THE SAME.(龋齿疫苗及制备方法。)China (中国)Huimin YAN, Wei SHI, Ying SUN, Jingyi YANG。(鄢慧民,石伟,孙颖,杨菁毅)。Date of Patent: April 9, 2014
6. US9,119,803. VACCINE FOR DENTAL CARIES AND METHODS FOR PREPARING THE SAME. HuiminYAN, Wei SHI, Ying SUN, Jingyi YANG(美国)Date of Patent: September 1, 2015