教育经历

1993.09-1997.09 香港科技大学，研究生，博士学位；

1986.07-1989.06 武汉大学，研究生，硕士学位；

1982.09-1986.07 武汉大学，本科，学士学位；

工作经历

2004- 至今    过敏及免疫相关疾病湖北省重点实验室主任；

2004.10- 至今  病毒学国家重点实验室，教授，博导；

2004.09-2004.12 日本福岛医科大学，免疫学系，访问研究员；

2002.05- 至今  武汉大学基础医学院，免疫学系，系主任，教授，博导；武汉大学“珞珈学者”特聘教授；国家杰出青年基金获得者

2001.08-2002.05 武汉大学，引进人才；武汉大学，基础医学院，微生物学及免疫学教研室，教授；

2001.02-2001.08 美国University of Maryland，College Park动物学系，研究专家 (Research Specialist)；

1997.09-2001.08 美国University of Maryland，College Park动物学系，博士后；

1989.06-1993.09 湖北医科大学，微生物及免疫学教研室，讲师；

学术兼职

中华医学会微生物及免疫学分会副主任委员

中国免疫学会理事会理事

中国生物化学与分子生物学会糖复合物专业委员会委员

国家自然基金委员会生命科学部专家评审组成员

湖北省免疫学会副理事长

湖北省微生物学会理事

《Infectious Disorders - Drug Targets》期刊编委 (Editorial Board Member)

《Virologic Sinica》期刊编委 (Editorial Board Member)

《Frontiers in Cellular and Infection Microbiology》期刊Review Editor

研究内容

主要开展感染免疫相关研究，重点研究胞内病原微生物（重点是丙型肝炎病毒、结核分枝杆菌等）感染及其糖免疫与致病的相关分子机理，并发展疾病诊疗、防治新技术与新方法。

主持项目

1. 科学技术部高技术研究发展中心重点研发计划项目

课题名称：代谢疾病及其心血管并发症中蛋白质糖基化的功能研究（项目编号：2018YFA0507603）

执行年限：2018-2023

承担角色：项目负责人

资助金额：2,383,500人民币

2. “十三五”国家重大传染病专项

课题名称：菌阴结核病结核菌（糖类）抗原／糖复合物标识及其产品（项目编号：2017ZX10201301-006）

执行年限：2017-2020

承担角色：项目负责人

资助金额：2,468,500人民币

3. “十二五”国家重大传染病专项

课题名称：结核分枝杆菌糖脂分子标识筛选、鉴定（项目编号：2012ZX10003002-015）

执行年限：2012-2016

承担角色：项目负责人

资助金额：2,466,200人民币

4. “十一五”国家重大传染病专项

课题名称：结核病诊断的分子标识研究（项目编号：2008ZX10003-005）

执行年限：2008-2012

承担角色：项目负责人

资助金额：14,000,000人民币

5. 国家973计划项目

课题名称：HCV导致APC和T／B细胞免疫耐受的机制研究（项目编号：2009CB522507）

执行年限：2008-2012

承担角色：项目负责人

资助金额：4,340,000人民币

6. 国家杰出青年基金

课题名称：医学病原微生物与感染（项目编号：81025008）

执行年限：2011-2014

承担角色：项目负责人

资助金额：2,000,000人民币

7. 国家自然科学基金重大研究计划项目

课题名称：Ficolin-2下调的LncRNA介导HCV免疫逃逸的分子机制研究（项目编号：91740120）

执行年限：2018-2020

承担角色：项目负责人

资助金额：1,000,000人民币

8. 国家自然科学基金项目

课题名称：以丙型肝炎病毒RNA-G4为新型靶标的配体分子的筛选及其抗病毒活性研究（项目编号：21572173）

执行年限：2016-2019

承担角色：项目负责人

资助金额：774,000人民币

9. 国家自然科学基金项目

课题名称：基于适配子靶向病毒蛋白的策略研究HCV导致肝癌的机制与规律（项目编号：31370197）

执行年限：2014-2017

承担角色：项目负责人

资助金额：800,000人民币

成果

1.Wang SR#, Min YQ#, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T*, Zhang XL*, Zhou X*. A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target. Sci Adv, 2016, 2(4): e1501535.

2.Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against Tuberculosis. J Am Chem Soc, 2016, 138(36): 11680-11689.

3.Bian WX#, Xie Y#, Wang XN, Xu GH, Fu BS, Li S, Long G, Zhou X*, Zhang XL*. Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication. Nucleic Acids Res, 2018, 47(1): 56-68.

4.Yuan CH, Qu ZL, Tang XL, Liu Q, Luo W, Huang C, Pan Q, Zhang XL*. Mycobacterium Tuberculosis mannose-capped lipoarabinomannan induces IL-10-producing B cells and hinders CD4+ Th1 immunity. iScience, 2018, 11: 13-30.

5.Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther, 2014, 22(5): 940-951.

6.Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol, 2014, 193(2): 783-796.

7.Pan Q, Luo F, Liu M, Zhang XL*. Oligonucleotide aptamers: promising and powerful diagnostic and therapeutic tools for infectious diseases. J Infect, 2018, 77(2):83-98.

8.Song N#, Tan Y#, Zhang LY#, Luo W, Guan Q, Yan MZ, Zuo RQ, Liu WX, Luo FL*, Zhang XL*. Detection circulating Mycobacterium tuberculosis specific DNA by droplet digital PCR for vaccine evaluation in challenged monkeys and TB diagnosis. Emerg Microbes Infect, 2018, 7(1): 78.

9.Luo W, Qu ZL, Zhang LY, Xie Y, Luo FL, Tan Y, Pan Q, Zhang XL*. Recombinant BCG::Rv2645 elicits enhanced protective immunity compared to BCG in vivo with induced ISGylation-related genes and Th1 and Th17 responses. Vaccine, 2018, 36(21): 2998-3009.

10.Ding Q, Shen Y, Li D, Yang J, Yu J, Yin Z, Zhang XL*. Ficolin-2 triggers antitumor effect by activating macrophages and CD8(+) T cells. Clin Immunol, 2017, 183: 145-157.

11.Yang YF, Zhou YD, Hu JC, Luo FL, Xie Y, Shen YY, Bian WX, Yin ZN, Li HL, Zhang XL*. FCN-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology, 2017, 151(4): 433-450.

12.Tang XL, Yuan CH, Ding QQ, Zhou YD, Pan Q, Zhang XL*. Selection and identification of specific glycoproteins and glycan biomarkers of macrophages involved in Mycobacterium tuberculosis infection. Tuberculosis (Edinb), 2017, 104: 95-106.

13.Qian XJ#, Zhang XL#, Zhao P, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Zhu YZ, Qi ZT. A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. Sci Rep, 2016, 6: 27268.

14.Zhao R#, Liu M#, Li X, Chen HY, Deng JH, Huang C, Zhang XL*, Pan Q*. A strategy of targeting B10 cell by CD19scFv-IL10R for tumor therapy. Biochem Bioph Res Co, 2018, 506(4): 990-996.

15.Wang YH, Ji J, Wang BC, Chen H, Yang ZH, Wang K, Luo CL, Zhang WW, Wang FB*, Zhang XL*. Tumor-Derived Exosomal Long Noncoding RNAs as Promising Diagnostic Biomarkers for Prostate Cancer. Cell Physiol Biochem, 2018, 46(2): 532-545.

16.Min YQ#, Duan XC#, Zhou YD, Kulinich A, Meng W, Cai ZP, Ma HY, Liu L, Zhang XL*, Voglmeir J*. Effects of microvirin monomers and oligomers on hepatitis C virus. Biosci Rep, 2017, 37(3). pii: BSR20170015.

17.Xiang T, Yang G, Liu X, Zhou Y, Fu Z, Lu F, Gu J, Taniguchi N, Tan Z, Chen X, Xie Y, Guan F, Zhang XL*. Alteration of N-glycan expression profile and glycan pattern of glycoproteins in human hepatoma cells after HCV infection. Biochim Biophys Acta, 2017, 1861(5 Pt A): 1036-1045.

18.Pan Q, Yan J, Liu Q, Yuan C, Zhang XL*. A single-stranded DNA aptamer against mannose-capped lipoarabinomannan enhances anti-tuberculosis activity of macrophages through downregulation of lipid-sensing nuclear receptor peroxisome proliferator-activated receptor γ expression. Microbiol Immunol, 2017, 61: 92-102.

19.Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang XL*. Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin, 2016, 31(5): 406-414.

20.Tang XL#, Wu SM#, Xie Y, Song N, Guan Q, Yuan C, Zhou X, Zhang XL*. Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis. J Infect, 2016, 72(5): 573-586.

21.Luo FL, Sun XM, Qu Z, Zhang XL*. Salmonella typhimurium-induced M1 macrophage polarization is dependent on the bacterial O antigen. World J Microbiol Biotechnol, 2016, 32(2): 22.

22.Ren Y, Min YQ, Liu M, Chi L, Zhao P, Zhang XL*. N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim Biophys Acta, 2016, 1860(8): 1764-1775..

23.Luo W, Qu ZL, Xie Y, Xiang J, Zhang XL*. Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect, 2015, 71(5): 534-543.

24.Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F, Zhang XL*. Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin, 2015, 30(4): 249-60.

25.Pan Q, Li Q, Liu S, Ning N, Zhang XL, Xu Y, Chang AE, Wicha MS. Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells, 2015, 33(7): 2085-2092.

26.Wang T, Hong T, Huang Y, Su H, Wu F, Chen Y, Wei L, Huang W, Hua X, Xia Y, Xu J, Gan J, Yuan B, Feng Y, Zhang XL, Yang CG, Zhou X. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc, 2015, 137(43): 13736-13739.

27.Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, and Zhou X*. Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 2015, 134: 30-36.

28.Tang XL#, Zhou YX#, Wu SM, Pan Q, Xia B, Zhang XL*. CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect, 2014, 69: 569-580.

29.Ding F, Yuan C, Wu F, Peng S, Tian S, Zhang XL*, Zhou X*. Diagnosis applications of new hepatoma carcinoma cell aptamers in vitro. Anal Methods, 2014, 6: 8110-8114.

30.Ren Y, Ding Q, Zhang XL*. Ficolins and infectious diseases. Virol Sin, 2014, 29(1): 25-32.

31.Tian T, Xiao H, Zhang XL, Peng S, Zhang X, Guo S, Wang S, Liu S, Zhou X, Meyers C, Zhou X. Simultaneously sensitive detection of multiple miRNAs based on a strand displacement amplification. Chem Commun (Camb), 2013, 49(1): 75-77.

32.Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL*. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8⁺ T cells. J Clin Immunol, 2012, 32: 820-836.

33.Deng M, Feng S, Luo F, Wang S, Sun X, Zhou X*, Zhang XL*. Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis using an asymmetrically split peroxidase DNAzyme. J Clin Microbiol, 2012, 50: 3443-3450.

34.Ning N, Pan Q, Zheng F, Teitz-Tennenbaum S, Egenti M, Yet J, Li M, Ginestier C, Wicha MS, Moyer JS, Prince ME, Xu Y, Zhang XL, Huang S, Chang AE, Li Q. Cancer stem cell vaccination confers significant antitumor immunity. Cancer Res, 2012, 72(7): 1853-1864.

35.Ma Y, Chen HD, Wang Y, Wang Q, Li Y, Zhao Y, Zhang XL*. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect, 2011, 13(12-13): 1099-1110.

36.Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Luo F, Zhong J, Zhou Y, Qi Z, Zhang XL*. Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother, 2010, 54(8): 3355-3364.

37.Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL*. IL-24 protects against Salmonella t yphimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells, Eur J Immunol, 2009, 39(12): 3357-3368.

38.Wang QL, Pan Q, Ma Y, Wang K, Sun P, Liu S,Zhang XL*. An attenuated Salmonella-vectored vaccine elicits protective immunity against Mycobacterium tuberculosis. Vaccine, 2009, 27: 6712-6722.

39.Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity, 2009, 30(3): 397-407.

40.Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4⁺T cells and macrophages. J Immunol, 2008, 180(5): 3158-3165.

奖励

2010年：国家杰出青年基金获得者

2010年：国家高层次人才工程

2013年：国务院政府特殊津贴获得者

2004年：教育部新世纪优秀人才

2018年：获得教育部“高等学校科学研究优秀成果奖 自然科学奖”二等奖 (排名第一)

2010年：获得中华医学科技二等奖 (排名第一)

2010年：获得湖北省自然科学一等奖 (排名第四)

2009年：获得湖北省自然科学成果奖二等奖 (排名第一)

2009年：获得全国女职工建功立业标兵荣誉

2005年：获得“中国青年女科学家奖”提名奖

2013年：首届湖北省医学领军人才入选者

2005年：获“金绣球学术奖”于第六届伤寒及其它沙门菌病国际学术年会