教育经历

2005.09-2011.07      中国科学院微生物研究所，研究生，博士学位

2001.09-2005.07      北京大学生命科学学院，本科，学士学位；

工作经历

2018.11-至今        武汉大学医学研究院，教授

2011.09-2018.10     美国南加州大学分子微生物与免疫学系，博士后

学术兼职

研究内容

以卡波氏肉瘤疱疹病毒(KSHV)，单纯疱疹病毒1型（HSV-1）及鼠γ疱疹病毒68(MHV68)为对象，开展下列研究：1.研究疱疹病毒抑制宿主抗病毒免疫反应的分子机制；2.鉴定调控疱疹病毒潜伏感染/裂解复制的关键宿主因子；3.建立肿瘤疱疹病毒感染致瘤的小动物模型，揭示肿瘤疱疹病毒感染引起肿瘤发生发展的机理；4.发展更有效的溶瘤病毒进行肿瘤免疫治疗。

主持项目

成果

1.        Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo GJ, Chen L, Stabell AC, Xia Z, Sawyer SL, Jung JU, Huang C, Feng P (2018). Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication. Cell Host&Microbe 24(2). 234-248 (Highlighted by Science Signaling http://stke.sciencemag.org/content/11/547/eaav3302)

2.        Zhang J, Feng H, Zhao J, Feldman ER, Chen S, Yuan W, Huang C, Akbari O, Tibbetts SA, and Feng P (2016). IkappaB Kinase epsilon Is an NFATc1 Kinase that Inhibits T Cell Immune Response. Cell Reports 16: 405-418

3.        Zhang J*, Feng H, Xu S, Feng P (2016). Hijacking GPCRs by viral pathogens and tumor. Biochem Pharmacol 114. 69-81. (Review)

4.        Zhang J*, Tian M, Xia Z, Feng P (2016). Roles of IκB kinase ε in the innate immune defense and beyond. Virologica Sinica 31(6). 457-465. (Review)

5.        Zhang J, Zhu L, Lu X, Feldman ER, Keyes LR, Wang Y, Fan H, Feng H, Xia Z, Sun J, Jiang T, Gao S, Tibbetts SA, and Feng P (2015). Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice. PLoS Pathogens 11:e1005001.

6.        Zhang J, He S, Wang Y, Brulois K, Lan K, Jung JU, and Feng P (2015). Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. PLoS Pathogens 11:e1004768.

7.        Minassian A^#, Zhang J^#, He S, Zhao J, Zandi E, Saito T, Liang C, and Feng P (2015).  An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathogens 11:e1005060. 

8.        Zhang J, Liu T, Tong X, Li G, Yan J, Ye X. Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening (2011). Antiviral Research 93:48-54.

9.        Zhang J, Li G, Ye X. Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II (2010). Journal of Virology 84:12619-27.

10.    Zhang J, Li G, Liu X, Wang Z, Liu W, Ye X. Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA (2009). Journal of General Virology 90:2751-8.

奖励

2011  中国科学院朱李月华优秀博士毕业生奖

2016  19th International Workshop on KSHV and Related Agents Travel award