姓名	姚镜	性别	男
	职务	细胞生物学系副主任	职称	教授
	学历	博士研究生	通讯地址	武汉大学生命科学学院2105室
	电话	027-68752148	邮编	430072
	传真	027-68752148	电子邮件	jyao@whu.edu.cn

 

教育经历

2006.09-2009.07      美国纽约州立布法罗大学, 联合培养博士生

2006.09-2009.07      华中科技大学，研究生，博士学位

2002.09-2005.06      华中科技大学，研究生，硕士学位；

1996.09-2000.06      华中科技大学，本科，学士学位；

 

工作经历

2019.03-至今        武汉大学病毒学国家重点实验室教授；

2012.12-至今        武汉大学病毒学生命科学学院教授；

2011.02-2012.12     华中科技大学，生命科学学院，分子生物物理教育部重点实验室，教授，博士生导师；

2005.10-2011.01     美国纽约州立布法罗大学，生理与生物物理系，先后担任研究助理与博士后；

2000.09-2002.08     深圳市特宝龙仪器仪表开发有限公司，项目经理；

 

学术兼职

中国神经科学学会“离子通道与受体专业委员会” 理事

中国生物物理学会“膜生物学专业委员会”理事

中国生物物理学会“神经生物物理与神经信息专业委员会” 理事

湖北省细胞生物学会 理事

湖北省生物物理学会 理事

 

研究内容

病毒感染导致的各种疾病常常伴随着关节或器官疼痛、肌肉乏力等症状，极大地影响了病人的身心健康与生活质量。研究表明，除了免疫系统在识别并清除病毒的过程中发挥重要作用外，神经系统通过各种方式调控病毒的复制、抗病毒免疫应答以及组织修复等过程。聚焦于膜离子通道的生理与生物物理学特性开展研究，致力于离子通道的门控调节，以阐述离子通道在神经信号调控以及免疫反应中的作用为主要研究目标，重点关注与痛觉及伤害性传导密切相关的离子通道的生物学功能和作用机制。

 

 

主持项目

1. 国家自然科学基金面上项目（基金号：31871174）

课题名称：TRPV2通道在树突状细胞中的表达及其在抗病毒免疫反应过程中的功能与机制研究

执行年限：2019-2022

承担角色：项目负责人

资助金额：610,000人民币

2. 国家自然科学基金重点项目（基金号：31830031）

课题名称: SUMO/deSUMO修饰在痛痒觉调控中的作用和机制

执行年限: 2019-2023

承担角色: 课题合作人

资助金额: 1,000,000人民币

3. 国家自然科学基金面上项目 (基金号: 31671209)

课题名称: 伤害性感受器TRPV2通道的内源性调节机制研究

执行年限：2017-2020

承担角色: 项目负责人

资助金额: 610,000人民币

4. 湖北省自然科学基金“杰出青年”项目 (2017CFA063)

课题名称: 磷酸化和泛素化修饰TRPV2通道在伤害性感受中的作用机制研究

执行年限：2017-2020

承担角色: 项目负责人

资助金额: 200,000人民币

5. 国家自然科学基金“海外及港澳学者合作研究”项目(基金号: 31728014)

课题名称：溶酶体膜胞吐事件与神经炎性疼痛之间的相互作用网络研究

执行年限：2018-2019

承担角色：课题合作人

资助金额：200,000人民币

6. 武汉大学“重点领域交叉学科创新团队”培育项目（基金号：2042017kf0242）

课题名称：神经免疫信号互作的生理与病理功能

执行年限：2017-2019

承担角色：主持人

资助金额：500,000人民币

7. 973重大蛋白质重大研究计划（项目编号：2014CB910300）

课题名称：重要新型膜离子通道门控和调节机制的结构基础

执行年限：2014-2018

承担角色：学术骨干

资助金额：1,210,000人民币

 

成果

(1)           Quan Tian^#, Juan Hu^#, Chang Xie^#, Kaidi Mei, Cuong Pham, Xiaoyi Mo, Régine Hepp, Sylvia Soares, Fatiha Nothias, Yuanyuan Wang, Qiang Liu, Fen Cai, Bo Zhong, Dongdong Li*, Jing Yao*. Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane. Proc. Natl. Aca. Sci. USA. 2019 Mar 12; 116(11):5170-5175. doi: 10.1073/pnas.1819635116.

(2)           Yan Wang^#, Yingwei Gao^#, Quan Tian^#, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao*, Tian-Le Xu, Michael X. Zhu, and Yong Li*. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nat. Commun., 2018; 9(1):1529. (*corresponding author, Recommended by Faculty of 1000)

(3)           He Sun^#, Qiang Zhang^#, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian–Chen Xiong, Yan Wu, Qi-Yun Zhu, Jing Yao, Hong-Bing Shu, Dandan Lin & Bo Zhong*. USP13 negatively regulates antiviral responses by deubquitinating STING. Nat. Commun., 2017, 8:15534.

(4)           Man Zhang^#, Meng-Xin Zhang, Qiang Zhang, Gao-Feng Zhu, Lei Yuan, Dong-Er Zhang, Qiyun Zhu, Jing Yao, Hong-Bing Shu and Bo Zhong*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016 Dec; 26(12): 1302-1319.

(5)           Yao Xiao^#, Maomao Gao, Luna Gao, Yu Zhao, Qiang Hong, Zhigang Li, Jing Yao, Hanhua Cheng*, and Rongjia Zhou*. Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes. Stem Cell Reports. 2016 Aug 23. pii: S2213-6711(16)30144-8. doi: 10.1016/j.stemcr.2016.07.020.

(6)           Yujie Ren^#, Yin Zhao, Dandan Lin, Ximing Xu, Qiyun Zhu, Jing Yao, Hong-Bing Shu and Bo Zhong*. The type I interferon-IRF7 axis mediates transcriptional expression of Usp25. J. Biol. Chem. 2016 Jun 17;291(25):13206-15. doi: 10.1074/jbc.M116.718080.

(7)           Chuangeng Zhang^#, Zili Xie^#, Xinxin Li, Jing Chen, Jing Feng, Yange Lang, Weishan Yang, Wenxin Li, Zongyun Chen, Jing Yao, Zhijian Cao^# and Yingliang Wu^#. Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1. Biochem. J., 2016 May 1;473(9):1257-66. doi: 10.1042/BCJ20160178.

(8)           Luna Gao^#, Pu Yang^#, Peizhong Qin^#, Yungang Lu, Xinxin Li, Quan Tian, Yang Li, Chang Xie, Jin-Bin Tian, Chengwei Zhang, Changlin Tian, Michael X. Zhu*, Jing Yao*. Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. Sci. Rep. 2016 Feb; 6, 20791; doi: 10.1038/srep20791. (^#corresponding author)

(9)           Chang Xie^#, Haowen Liu^#, Na Pan, Jiuping Ding and Jing Yao*. The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols. Acta Pharmacol. Sin. 2016 Jan; 37(1):124-33. (^#corresponding author)

(10)        Xiang Yang Zhang^#, Jingmin Wen^#, Wei Yang^#, Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou, Jing Yao*, Xue Zhang, Jing Yu Liu*. Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain. Am. J. Hum. Genet., 2013 Nov. 7; 93(5):957-66. Doi: 10.1016/j.ajhg.2013.09.016 (^#corresponding author)

(11)        Lu Zeng^#, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao, Jing Yao and Xianqin Zhang*. A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family. Mol Vis. 2013 Nov 14;19:2244-9.

(12)        Ying Wu^#, Yongfeng Liu^#, Panpan Hou^#, Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li, Jing Yao, Yuexuan Zhang, Feng Qin*, Jiuping Ding*. TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons. PLoS One. 2013 Oct 16; 8(10):e78203. doi: 10.1371/journal.pone.0078203.

(13)        Panpan Hou^#, Wenping Zeng^#, Geliang Gan^#, Caixia Lv^#, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu, Jing Yao, Aguan D., Wei, Sheng Wang and Jiuping Ding*. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2). Sci Rep. 2013 Apr 16; 3:1666. P1-8. doi: 10.1038/srep01666.

(14)        Lisi Wei^#, Su Chen^#, Xianju Huang, Jing Yao and Xiangming Liu*. Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons. Eur J Pharmacol. 2013 Feb 28; 702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052. Epub 2013 Feb 8.

(15)        Wei Wang^#, Feng Xiao^#, Xuhui Zeng, Jing Yao, Ming Yuchi and Jiuping Ding*. Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents. Plos One. 2012 Mar; 7(4):e35208. Epub 2012 Apr 20.

(16)        Cheng Wang^#, Yulei Li^#, Lei Shi^#, Jie Ren, Monica Patti, Tao Wang, João R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang, Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang* & Jing-Yu Liu*. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Nat Genet. 2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077.

(17)        Beiying Liu^#, Jing Yao^# and Feng Qin*. Hysteresis of Gating Underlines Sensitization of TRPV3 Channels. J Gen Physiol. 2011 Nov; 138(5):509-20. (^#Co-first author, Recommended by Faculty of 1000)

(18)        Jing Yao^#, Beiying Liu^# and Feng Qin*. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc. Natl. Aca. Sci. USA. 2011 Jul 5; 108(27):11109-14.

(19)        Jing Yao^#, Beiying Liu^# and Feng Qin*. Pore turret of thermal TRP channels is not essential for temperature sensing. Proc. Natl. Aca. Sci. USA. 2010, Aug 10; 107(32):E125.

(20)        Jing Yao^#, Beiying Liu^# and Feng Qin*. Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels. Biophys. J. 2010 Sep 22; 99(6):1743-53.

(21)        Beiying Liu^#, Jing Yao^# Yingwei Wang^#, Hui Li and Feng Qin*. Proton inhibition of Unitary Currents of Vanilloid Receptors. J Gen Physiol. 2009 Aug 31; 134(3):243-58. (^†Co-first author)

(22)        Jing Yao^#, Beiying Liu^# and Feng Qin*. Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies. Biophys. J. 2009 May 6; 96(9): 3611-9.

(23)        Jing Yao^# and Feng Qin*. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1. PLos. Biol. 2009 Feb.24, 7 (2): e46.

(24)        Sujung Ryu^#, Beiying Liu^#, Jing Yao^#, Qiang Fu^# ang Feng Qin. Uncoupling proton activation of vanilloid receptor TRPV1. J Neurosci. 2007 Nov 21，27(47): 12797-807. (^†Co-first author)

(25)        Xiaotian Tong^#, Jing Yao^#, Feng He, Xiang Chen, X. Zheng, Chang Xie, Gong Wu, Naixia Zhang, Jiuping Ding and Houming Wu. NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position. Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 890-9. (^†Co-first author)

(26)        Hui Li^#, Jing Yao^#, Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu*, and Jiuping Ding*. Interaction sites between the Slo1 pore and the NH₂ terminus of the β2 subunit, probed with a three-residue sensor. J Biol Chem, 2007, 282(24): 17720-8. (^†Co-first author)

(27)        Jing Yao^#, Hui Li^#, Geliang Gan, Ying Wu, and Jiuping Ding*. Residue Phe266  in S5-S6 loop is not critical for Charybdotoxin binding to Ca²⁺-activated K⁺ (mSlo1) channels. Acta Pharmacologica Sinica, 2006, 27: 945-9.

(28)        Jing Yao^#, Xiang Chen^#, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu*, and Jiuping Ding*. BmP09, a “Long Chain” scorpion peptide blocker of BK channels. J Biol Chem, 2005, 280: 14819-28.

^# These authors contributed equally to the work.

 

奖励

2018 获“武汉大学弘毅学堂优秀教育工作者”称号

2016 获第三届生命科学学院“我心中的优秀班级导师”称号

2014 武汉市优秀青年科技工作者

2011 湖北省楚天学者特聘教授

2011 湖北省优秀博士论文

2011 湖北省优秀硕士论文