教育经历

2006.09-2009.06     中国科学院武汉病毒所，研究生，博士学位

2000.09-2003.06     华中农业大学，研究生，硕士学位；

1995.09-1999.06     长江大学，本科，学士学位；

工作经历

2018.04-至今        武汉大学医学研究院教授；

2012.06-2018.03    哈佛大学微生物与免疫系博士后；

2010.01-2012.05    佛罗里达州立大学生物学系，博士后；

2009.07-2009.12    中国科学院武汉病毒所助理研究员；

2003.07-2006.08    长江大学讲师；

研究内容（限200字）

利用蛋白质组学技术绘制狂犬、流感、寨卡和人类乳头瘤等病毒与宿主相互作用的网络图谱，研究病毒调节宿主细胞先天免疫以及宿主抵御病毒感染的相关分子机制；开展ZMPSTE24 抑制病毒侵入宿主细胞的分子机制研究；研究先天性免疫分子的蛋白相互作用网络与病原物细胞质感应的相关研究。以了解病毒的感染复制、致病致瘤和免疫逃逸的相关分子机制，同时进一步发现新的抵御不同病毒感染的宿主蛋白因子及其作用机理。 

成果（限40篇）

1. LI S., FUB., WANG L., DORF M. E. Zmpste24 is downstream effector of interferon-inducedtransmembrane antiviral activity, DNA and cell biology 2017,36: 513-517.(cited:1)

2.  FUB., ZHAO M., WANG L., PATIL G., SMITH J. A., JUNCADELLA I. J. et al. RNAiscreen and proteomics reveal NXF1 as a novel regulator of IRF5 signaling,Scientific reports 2017,7: 2683. (cited:3)

3.  FUB., WANG L., LI S. and DORF M. E. ZMPSTE24 defends against influenza and otherpathogenic viruses, Journal of Experimental Medicine.2017,214(4):919-929. doi:10.1084/jem.20161270 (cited:11)

4.  WANGL. *, FU B. *, LI W.,PATIL G., LIU L., DORF M. E. et al. Comparative influenza protein interactomes identifythe role of plakophilin 2 in virus restriction, Nature communications.2017, 8:13876. doi:10.1038/ncomms13876 (cited:13)

5.  FuB., WANG L., DING H., SCHWAMBORN J. C., Li S., DORF M. E. TRIM32 senses andrestricts influenza A virus by ubiquitination of PB1 polymerase, PLoS pathogens2015,11(6): e1004960. (cited:42)

6.  LIW., AVEY D., FU B., WU J., MA S.,LIU X. et al. Kaposi's sarcoma-associated herpesvirusinhibitor of cGAS (KicGAS), encoded by ORF52, is an abundant tegument proteinand is required for production of infectious progeny viruses, Journal ofvirology.2016,90(11): 5329-5342. (cited:8)

7.  LIW., AVEY D., FU B., WU J., MA S., LIU X. et al. KSHV inhibitor of cGAS (KicGAS) encoded byORF52 is an abundant tegument protein and required for production of infectiousprogeny viruses, Journal of Virology.2016: 02675-02615. (cited:8)

8.  WUJ., AVEY D., LI W., GILLRN J., FU B., MILEY W., WHITBY D., ZHU F. ORF33 andORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required forOptimal Production of Infectious Progeny Viruses. Journal ofVirology.2015,90(4):1741-56. (cited:8)

9.  WUJ., LIW, SHAO Y., AVEY D., FU B., GILLEN J. et al. Inhibition of cGAS DNAsensing by a herpesvirus virion protein, Cell host & microbe.2015,18:333-344. (cited:68)

10.FU B., KUANG E., LIW., AVEY D., LI X.,TURPIN Z. et al. Activation of p90 ribosomal S6 kinases by ORF45 of Kaposi'ssarcoma-associated herpesvirus is critical for optimal production of infectiousviruses, Journal of virology.2015, 89(1): 195-207. (cited:22)

11.    GREENFELDH., TAKASAKI K., WALSH M. J., ERSING I., BERNHARDT K., MA Y.,      FU B. et al. TRAF1 coordinatespolyubiquitin signaling to enhance Epstein-Barr virus LMP1-mediated growth andsurvival pathway activation, PLoS pathogens.2015: 11(5): e1004890. (cited:22)

12.LI S.,WANG L.,FU B.,DORF M.E. Trim65: acofactor for regulation of the microRNA pathway. RNA Biol. 2014,11(9):1113-21(cited:7)

13.LI S. *, WANG L. *, FU B. *, Berman M. A.,Diallo A., Dorf M. E. TRIM65 regulates microRNA activity by ubiquitination ofTNRC6, Proc Natl Acad Sci. 2014: 111(19): 6970-5. (cited:41)

14.FU B., LI S., WANG L., BERMAN M. A. andDORF M. E. The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination. CellResearch.2014, 24(4):510. (cited:21)

15.OUYANG X., ZENG Y., FU B., WANG X., CHENW., FANG Y. et al. Genotypic analysis of Kaposi's sarcoma-associatedherpesvirus from patients with Kaposi's sarcoma in Xinjiang, China. Viruses.2014,6(12):4800-4810. (cited:11)

16.DUAN Y., YE H., ZAVALA A.G., YANG C., MIAOL., FU B., SEO KS *, Davrinche C,Luo MH, Fortunato EA. Maintenance of largenumbers of virus genomes in human cytomegalovirus-infected T98G glioblastomacells.Journal of Virology. 2014,88:3861-3873. (cited:18)

17.FU B., XIA F., LI B., OUYANG X., GAO S.,YANG R. and WANG L.. Gender differences in Kaposi's sarcoma-associatedherpesvirus infection in a population with schistosomiasis in ruralChina.Epidemiological Report. 2012 ,65(4):350-353. (cited:6)

18.DUAN Y., MIAO L., YE H., YANG C., FU B.,SCHWARTZ P. H. et al. A faster immunofluorescence assay for trackinginfection progress of human cytomegalovirus, Acta Biochim Biophys Sin. 2012:44(7): 597-605. (cited:10)

19.    LIANGQ., FU B., WY F., LI X., YUAN Y., ZHU F. ORF45 of Kaposi's sarcoma-associatedherpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate. Journalof Virology.2012. 86(18):10162-10172 (cited:52)

20.    KUANGE., FU B., LIANG Q., MYPING J., ZHU F. Phosphorylation of eIF4B by theORF45/RSK signaling axis facilitates protein translation during KSHV lyticreplication. 2011 Journal of Biological Chemistry. 2011,286(48):41171-82(cited:48)

21.    FUB., SUN F, LI B, YANG L, ZENG Y, SUN X. et al. Kaposi's Sarcoma-Associated HerpesvirusSeroprevalence and risk factors in Xinjiang, China. 2009 Journal of MedicalVirology.2009, 81(8):1422-1431 (cited:49)

22.    OUYANGX., FU B.,ZENG Y.,XU F.,WANG L. Establishment of an ELISA to detect Kaposi’s sarcoma-associated herpesvirus using recombinantORF73. Virologica Sinica.2010,25(3):168-176.

23.    FUB.,LI B., WANG L. Immunogenicity analysis of prokaryotic expression products ofKaposi’s sarcoma associated herpesvirus orf65. VirologicaSinica.2008,23 (3):196-202.

24.    FUB., LI B., OUYANG X., ZENG Y., XU F., WANG L. Expression of Kaposi’s sarcoma-associated herpesvirus ORFK8. 1 andits preliminary diagnostic application. Virologica Sinica.2009,24 (3):202-208.