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邬开朗

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姓名

邬开朗

性别

职务

 

职称

副教授

学历

博士研究生

通讯地址

武汉大学生命科学学院5017

电话

18971054971

邮编

430072

传真

027-68754592

电子邮件

wukailang@whu.edu.cn  

 

教育经历

2002.09-2005.12      武汉大学名科学学院,研究生,博士学位

1982.09-1986.06      重庆医科大学,本科,学士学位;

 

工作经历

2010.09-至今        武汉大学生命科学学院副教授;

2007.07-2010.08     美国明尼苏达大学医学院药理学系,博士后;

1993.11-2007.06     武汉大学生命科学学院病毒学系,讲师;

1986.07-1993.10     武汉大学生物工程研究中心,助教;

 

学术兼职

中国微生物学会会员

 

研究内容

致力于病毒感染(包括乙型肝炎病毒(HBV)、肠道病毒71型(EV71)、寨卡病毒(ZIKV)等)致病、致炎症分子机制研究,及抗病毒药物研发。

 

主持项目

1. 国家重点研发计划

课题名称:多靶点联合干预提高经治慢性乙型肝炎临床治愈率的个体化精准治疗策略研究(项目编号:2017ZX10202201

执行年限:2017-2020

承担角色:子课题负责人

资助金额:1,477,000元人民币

2. 国家自然科学基金面上项目(基金号:31270206

课题名称: HBx 调节CTHRC1 表达的分子机制及其在介导肝癌形成中的作用研究

执行年限:2013-2016

承担角色:主持人

资助金额:780,000元人民币

3. 国家自然科学基金面上项目(基金号:31170153

课题名称: 肠道病毒71型识别并结合宿主细胞受体的分子机制研究

执行年限:2012-2015

承担角色:主持人

资助金额: 640,000元人民币

4.湖北省科技厅社发项目 (基金号:)

课题名称: 白细胞介素27抗乙肝病毒临床前研究

执行年限:2011-2014

承担角色: 主持人

资助金额: 200,000元人民币

 

成果

1.          Xu W, Ma C, Zhang Q, Zhao R, Hu D, Zhang X, Chen J, Liu F, Wu K, Liu Y, Wu J. PJA1 Coordinates with the SMC5/6 Complex to Restrict DNA Viruses and Episomal Genes through Interferon-independent Manner. J Virol. 2018 Sep 5.

2.          Wang W, Li G, De Wu, Luo Z, Pan P, Tian M, Wang Y, Xiao F, Li A, Wu K, Liu X, Rao L, Liu F, Liu Y, Wu J.Z ika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion. Nat Commun. 2018 Jan 9;9(1):106.

3.          Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K, Liu Y, Wu J HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress.J Immunol. 2017 Nov 1;199(9):3280-3292. 

4.          Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, Bai L, Zhang Q, Zhu C, Xiong Y, Wu K, Liu F, Liu Y, Wu J.HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection.PLoS Pathog. 2017 Aug 30;13(8)

5.           Yu Y, Wan P, Cao Y, Zhang W, Chen J, Tan L, Wang Y, Sun Z, Zhang Q, Wan Y, Zhu Y, Liu F, Wu K, Liu Y, Wu J.Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action.Sci Rep. 2017 May 11;7(1):1729. doi: 10.1038/s41598-017-01773-6.

6.          Liu Z, Dai X, Wang T, Zhang C, Zhang W, Zhang W, Zhang Q, Wu K, Liu F, Liu Y, Wu J.Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells.Cancer Lett. 2017 Aug 1;400:149-160. doi: 10.1016/j.canlet.2017.04.017. Epub 2017 Apr 25.

7.          Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, Wu K, Liu F, Liu Y, Wu J.

GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PLoS Pathog. 2017 Apr 10;13(4):

8.          Chen J, Xu W, Chen Y, Xie X, Zhang Y, Ma C, Yang Q, Han Y, Zhu C, Xiong Y, Wu K, Liu F, Liu Y, Wu J. MMP-9 Facilitates Hepatitis B Virus Replication through Binding with IFNAR1 to Repress IFN/JAK/STAT Signaling.J Virol. 2017 Jan 25. pii: JVI.01824-16. doi: 10.1128/JVI.01824-16. [Epub ahead of print]

9.          Li G, Pan P, He Q, Kong X, Wu K, Zhang W, Liu Y, Huang H, Liu J, Zhang Z, Wu, Lai X, Liu X, Wu J. Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China.Virol Sin. 2017 Jan 23. doi: 10.1007/s12250-016-3872-8. [Epub ahead of print]

10.       Wang W, Xiao F, Wan P, Pan P, Zhang Y, Liu F, Wu K, Liu Y, Wu J. EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex. PLoS Pathog. 2017 Jan 6;13(1):e1006123

11.       Han Y, Wang L, Cui J, Song Y, Luo Z, Chen J, Xiong Y, Zhang Q, Liu F, Ho W, Liu Y*, Wu K*, Wu J*. SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5'UTR RNA. J Cell Sci. 2016 Dec 15;129(24):4534-4547.

12.       Zhu C, Gao G, Song H, Xu F, Wu K, Liu X. Hepatitis B virus inhibits apolipoprotein A5 expression through its core gene. Lipids Health Dis. 2016 Oct 10;15(1):178.

13.       Zhang W, Han D, Wan P, Pan P, Cao Y, Liu Y, Wu K*, Wu J*.ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation. Sci Rep. 2016 Oct 6;6:34543.

14.       Zhang X, Wang T, Dai X, Zhang Y, Jiang H, Zhang Q, Liu F, Wu K, Liu Y, Zhou H, Wu J. Golgi protein 73 facilitates the interaction of hepatitis C virus NS5A with apolipoprotein E to promote viral particle secretion. Biochem Biophys Res Commun. 2016 Oct 28;479(4):683-689.

15.       Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, Wu K, Wu J.

Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.Cancer Lett. 2016 Feb 1;371(1):107-16. 

16.     Lili Lu, Qi Zhang, Kailang Wu, Xi Chen, Yi Zheng, Chengliang Zhu, Jianguo Wu*. Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-κB signal cascade. Cancer Letters 2015; 356(2):470-478.

17.     Qi Zhang, Liang Wei, Hongchuan Yang, Wanqi Yang, Qingyu Yang, Zhuofan Zhang, Kailang Wu, Jianguo Wu*. Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection. Cancer Letters 2015; S0304-3835(15)00703-X

18.     Jian Shang, Yuan Zheng, Xiaohong Guo, Jiayin Mo, Xueping Xie, Ying Xiong, Yingle Liu, Kailang Wu*, Jianguo Wu*. Hepatitis B virus replication and sex-determining region Y box 4 production are tightly controlled by a novel positive feedback mechanism. Scientific Reports 2015; 5:10066.

19.     Lan Bai, Wei Zhang, Li Tan, Hongchuan Yang, Maolin Ge, Chengliang Zhu, Rui Zhang, Yanhua Cao, Junbo Chen, Zhen Luo, Wenzhe Ho, Fang Liu, Kailang Wu*, Jianguo Wu*. Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication. Journal of Molecular Cell Biology 2015; 7(6):543-56.

20.       Song,Yu;Cheng,Xin;Yang,Xiaoxia;Zhao,Rong;Wang,Peili;Han,Yang;Luo,Zhen;Cao,Yanhua;Zhu,Chengliang;Xiong,Ying;Liu,Yingle;Wu,Kailang;*Wu, Jianguo Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA. International Journal of Biochemistry & Cell Biology, 2015/5. 62, pp 36-46,

21.     Rui Zhang, Yanhua Cao, Lan Bai, Chengliang Zhu, Rui Li, Hui He, Yingle Liu, Kailang Wu, Fang Liu*, Jianguo Wu*. The collagen triple helix repeat containing 1 facilitates hepatitis B virus-associated hepatocellular carcinoma progression by regulating multiple cellular factors and signal cascades. Molecular Carcinogenesis 2015; 54(12):1554-1566.

22.       Lu,Lili;Zhang,Qi;Wu,Kailang;Chen,Xi;Zheng,Yi;Zhu,Chengliang;*Wu,JianguoHepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-kappaB signal cascadeCancer Letters, 356(2 Pt B),2015/1/28 pp 470-478.

23.       Wenjing Zhang;Junyan Tao;Xiaoping Yang;Zhuliang Yang;Li Zhang;Hongsheng Liu;Kailang Wu; *Jianguo WuAntiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infectionBiochemical and Biophysical Research Communications, 2014/7/4.449(3), pp 307-312.

24.       Zhu C, Liu X, Wang S, Yan X, Tang Z, Wu K, Li Y, Liu F. Hepatitis C virus core protein induces hypoxia‑inducible factor 1α-mediated vascular endothelial growth factor expression in Huh7.5.1 cells. Mol Med Rep. 2014 May;9(5):2010-4.

25.       Luo Z, Dong X, Li Y, Zhang Q, Kim C, Song Y, Kang L, Liu Y, Wu K*, Wu J *PolyC-binding protein 1 interacts with 5'-untranslated region of enterovirus 71 RNA in membrane-associated complex to facilitate viral replication. PLoS One. 2014 Jan 29;9(1):e87491

26.       Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, Wang Q, Bai L, Liu Y, Wu K, Wu J. IL-27, a cytokine, and IFN-λ1, a type III IFN, are coordinated to regulate virus replication through type I IFN. J Immunol. 2014 Jan 15;192(2):691-703

27.       Chen Y, Chen J, Wang H, Shi J, Wu K, Liu S, Liu Y, Wu J. HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1. PLoS Pathog. 2013 Apr;9(4):

28.       Li Y, Zhang Q, Liu Y, Luo Z, Kang L, Qu J, Liu W, Xia X, Liu Y, Wu K, Wu J.Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways. J Virol. 2012 Dec;86(23):12531-43.

29.       Liu L, Cao Z, Chen J, Li R, Cao Y, Zhu C, Wu K, Wu J, Liu F, Zhu Y.

Influenza A Virus Induces Interleukin-27 through Cyclooxygenase-2 and Protein Kinase A SignalingJournal of Biological Chemistry, 287(15), pp 11899-11910, 2012/4/6.

30.       Kailang Wu , Guiqing Peng , Matthew Wilken , Robert J. Geraghty , and Fang Li Mechanisms of host receptor adaptation by SARS coronavirus. J Biol Chem. 2012 Mar 16;287(12):8904-11

31.       Chen Y, Shen A, Rider PJ, Yu Y, Wu K, Mu Y, Hao Q, Liu Y, Gong H, Zhu Y, Liu F, Wu J.A liver-specific microRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. FASEB J. 2011 Dec;25(12):4511-21

32.       Kailang Wu , Lang Chen , Guiqing Peng , Wenbo Zhou , Christopher A. Pennell, Louis M. Mansky , Robert J. Geraghty, and Fang Li (2011), A Virus-binding Hotspot on HumaAngiotensin-converting Enzyme 2 is Critical for the Binding of Two Different Coronaviruses J Virol . 85(11):5331-7.

33.       Jing Y, Lu H, Wu K, Subramanian IV, Ramakrishnan S.Inhibition of ovarian cancer by RGD-P125A-endostatin-Fc fusion proteins. Int J Cancer. 2011 Jan 10. [Epub ahead of print]

34.       Kailang Wu,Weikai Li,Quiqing Peng,Fang Li(2009). Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor.PNAS 106, 19970-19974

35.       Huang J, Wu KL, Xu YL, Si W, Zhang JL, Zhu Y, Wu JG (2008). Putative tumor suppressor YueF affects the function of hepatitis B virus X protein in hepatoma cell apoptosis and p53 expression. Biotechnol Lett 30(2):235-242. (IF:1.134)

36.       Lu LL, Wei L, Peng GQ, Mu YX, Wu KL, Kang L, Zhu Y, Wu JG (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371:61-70. (IF:3.525)

37.       TANG Hong-bin; WU Kai-lang; JIANG Kun; PENG Ling (2009) Inhibition of HBV Infection in Mouse Model by Dual Small Interfering RNA Treatment. Chinese Journal of Comparative Medicine,19(9):1-6.

38.       Tong WP, Zhou Y, Wang XX, Yang F, Wu KL, Wu JG, Zhang Y (2008). An accurate quantitative method for screening effective siRNA probes targeting a hepatitis B virus transcript in single living cells. Biochem Bioph Res Co. 367(4):866-73 (IF:2.855)

39.       Peng GQ, Yan Y, Wang SQ, Zhu CL, Hu J, Lu LL, Li W, Yan XH, Wei W, Mu YX, Chen YN, Feng Y, Gong R, Wu KL, Zhu Y, Zhang FM, Zhang XL, Wu JG (2008). Borna disease virus P protein affects neural transmission through interacting with gamma aminobutyric acid receptor-associated protein. J Virol .82(24)12487-12497. (IF:5.341)

40.       Wu KL, Mu YX, Hu J, Lu L, Zhang X, Yang YB, Li Y, Liu F, Song DG, Zhu Y, Wu JG (2007). Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antivir Res 74:142-149. (IF:2.878)

 

奖励

2013 湖北省科协创新创业人才奖 

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