教育经历

2001-2005    北京大学生命科学学院，学士

2005-2011    中国科学院微生物研究所，博士

工作经历

2011-2018    美国南加州大学分子微生物与免疫学系，博士后

2018-至今     武汉大学医学研究院、高致病性病毒与生物安全全国重点实验室，教授、博士生导师

研究内容

主要从事疱疹病毒感染复制与抗病毒免疫相关研究，具体方向包括：

1. 揭示疱疹病毒拮抗宿主抗病毒免疫反应的分子机制；

2. 鉴定调控疱疹病毒裂解再激活的关键病毒蛋白及宿主因子；

3. 解析肿瘤疱疹病毒感染促进肿瘤发生发展的机制；

4. 开发新型溶瘤疱疹病毒以提升肿瘤免疫治疗效果。

主持项目

主持国家海外高层次人才计划青年项目、国家重点研发计划课题及国家自然科学基金面上项目等

成果（限10篇）

1. Liting Zhang*, Chuchu Zhang, Junjie Zhang*. (2025) Beyond interferons: Non-canonical roles of MITA/STING. Cell Insight 4, 100266.

2. Shaowei Wang, Xuezhang Tian, Yunhong Zhong, Xiaoyu Xie, Ming Gao, Chuchu Zhang, Xi Cheng, Yining Qi, Bo Zhong, Pinghui Feng, Ke Lan, Junjie Zhang*. (2025) Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy. PLoS Pathogens 21 (4), e1013052

3. Shuo Wang, An Song, Jun Xie, Yuan-Yuan Wang, Wen-Da Wang, Meng-Jie Zhang, Zhi-Zhong Wu, Qi-Chao Yang, Hao Li, Junjie Zhang*, Zhi-Jun Sun*. (2024) Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity. Nature communications 15 (1), 3669

4. Yaru Zhou, Xuezhang Tian, Shaowei Wang, Ming Gao, Chuchu Zhang, Jiali Ma, Xi Cheng, Lei Bai, Hai-Bin Qin, Min-Hua Luo, Qingsong Qin, Baishan Jiang, Ke Lan, Junjie Zhang*. (2024) Palmitoylation of KSHV pORF55 is required for Golgi localization and efficient progeny virion production. PLoS Pathogens 20 (4), e1012141

5. Shaowei Wang, Xuezhang Tian, Yaru Zhou, Jun Xie, Ming Gao, Yunhong Zhong, Chuchu Zhang, Keying Yu, Lei Bai, Qingsong Qin, Bo Zhong, Dandan Lin, Pinghui Feng, Ke Lan, Junjie Zhang*. (2024) Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases. PLoS Pathogens 20 (1), e1011943

6. Liting Zhang, Congqing Jiang, Yunhong Zhong, Kongliang Sun, Huiru Jing, Jiayu Song, Jun Xie, Yaru Zhou, Mao Tian, Chuchu Zhang, Xiaona Sun, Shaowei Wang, Xi Cheng, Yuelan Zhang, Wei Wei, Xiang Li, Bishi Fu, Pinghui Feng, Bing Wu, Hong-Bing Shu, Junjie Zhang*. (2023) STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nature Cell Biology (25). 1208–1222

7. Xuezhang Tian, Yaru Zhou, Shaowei Wang, Ming Gao, Yanlin Xia, Yangyang Li, Yunhong Zhong, Wenhao Xu, Lei Bai, Bishi Fu, Yu Zhou, Hye-Ra Lee, Hongyu Deng, Ke Lan, Pinghui Feng, Junjie Zhang*. (2023) Genome-Wide CRISPR-Cas9 Screen Identifies SMCHD1 as a Restriction Factor for Herpesviruses. mBio 14 (2). e00549-23

8. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang*. (2023) Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. Molecular Therapy Oncology (29). 61–76

9. Wen Su, Wei Qiu, Shu-Jin Li, Shuo Wang, Jun Xie, Qi-Chao Yang, Jiming Xu, Junjie Zhang*, Zhigang Xu*, Zhi-Jun Sun*. (2022) A Dual-Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis. Advanced Materials 35 (11). 2209379

10. Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng*, Junjie Zhang*. (2020) DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity. Nature communications 11 (1). 1-15