依托高等级生物安全团簇平台，主要从事高致病性病毒与生物安全基础科研任务：主要包括新冠、克里米亚-刚果出血热等高致病性病毒小动物或非灵长类感染模型的研究；参与疫苗研发工作；利用构建的尼帕病毒、黄热病毒、寨卡病毒等动物感染模型，进行疫苗与药物的药效学评估。作为生物安全操作培训和考核导师，对进入生物安全二级和三级实验室的科研人员开展培训和考核工作。
Tan S#, Zhao J#, Hu X#, Li Y#, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J. Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing). 2023 Dec 30;68(24):3192-3206
Gao G#, Hu X#, Zhou Y#, Rao J, Zhang X, Peng Y, Zhao J, Yao Y, Liu K, Liang M, Liu H, Deng F, Xia H, Shan C, Yuan Z. Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque. Virol Sin. 2022 Apr;37(2): 299-302
Hu X, Tian L, Li J, Zhou Y, Chen X, Mu J, Bai H, Zhang Y, Wang Y. Effects of CRM1-dependent nuclear export inhibition on viral structural protein nuclear accumulation during Autographa californica multiple nucleopolyhedrovirus infection. Virus Res. 2021 Oct 2;303: 198504
Pan X#, Shi J#, Hu X#, Wu Y, Zeng L, Yao Y, Shang W, Liu K, Gao G, Guo W, Peng Y, Chen S, Gao X, Peng C, Rao J, Zhao J, Gong C, Zhou H, Lu Y, Wang Z, Hu X, Cong W, Fang L, Yan Y, Zhang J, Xiong H, Yi J, Yuan Z, Zhou P, Shan C, Xiao G. RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates. Cell Discov. 2021 Sep 7;7(1):82
Yao Y#, Wang Z#, Jiang R#, Hu X#, Zhang H, Zhou Y, Gao G, Chen Y, Peng Y, Liu M, Zhang Y, Min J, Lu J, Gao X, Guo J, Peng C, Shen X, Li Q, Zhao K, Yang L, Wan X, Zhang B, Wang W, Wu J, Zhou P, Yang X, Shen S, Shan C, Yuan Z, Shi Z. Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates. Virol Sin. 2021 Oct;36(5):879-889
Gu C#, Cao X#, Wang Z#, Hu X#, Yao Y, Zhou Y, Liu P, Liu X, Gao G, Hu X, Zhang Y, Chen Z, Gao L, Peng Y, Jia F, Shan C, Yu L, Liu K, Li N, Guo W, Jiang G, Min J, Zhang J, Yang L, Shi M, Hou T, Li Y, Liang W, Lu G, Yang C, Wang Y, Xia K, Xiao Z, Xue J, Huang X, Chen X, Ma H, Song D, Pan Z, Wang X, Guo H, Liang H, Yuan Z, Guan W, Deng SJ. A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351. MAbs. 2021 Jun 7;13(1):1930636
