教育经历

2005.09-2009.07    中国农业大学，学士

2009.09-2014.07    中国农业大学，博士

工作经历

2014.09-2019.08    Washington University in St. Louis，博士后

2019.09-2021.02    Washington University in St. Louis，讲师

2021.03-至今          中国科学院武汉病毒研究所，研究员

研究内容

课题组主要利用生物化学、生物物理学以及病毒学等手段从事以下研究：1）病原微生物关键酶的催化机制；2）病毒-宿主互作的分子机制；3）传染病防治手段。

主持项目

1. 国家自然科学基金面上项目，主持，项目名称：KSHV核糖核苷酸还原酶的酶活性调控及其拮抗宿主限制因子的结构生物学研究

2. 国家自然科学基金青年科学基金项目，主持，项目名称：蜱传布尼亚病毒SFTSV和CCHFV核糖核蛋白体形成的结构基础与分子机制

3. 中国科学院率先行动百人计划择优支持项目，主持

4. 湖北省青年A类项目，主持

成果（限10篇）#并列第一作者，*通讯作者）

1. Ma, C.B., Liu, C., Park, Y.J., Tang, J., Chen, J., Xiong, Q., Lee, J., Stewart, C., Asarnow, D., Brown, J., Tortorici, M.A., Yang, X., Sun, Y.H., Chen, Y.M., Yu, X., Si, J., Liu, P., Tong, F., Huang, M.L., Li, J., Shi, Z.*, Deng, Z.*, Veesler, D.* and Yan, H.* (2025) Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses. Cell, 188, 1693-1710 e1618.

2. An, Q., Wang, Y., Tian, Z., Han, J., Li, J., Liao, F., Yu, F., Zhao, H., Wen, Y., Zhang, H. and Deng, Z.* (2024) Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex. Cell Res, 34, 545-555.

3. Yang, J., Li, X., He, Q., Wang, X., Tang, J., Wang, T., Zhang, Y., Yu, F., Zhang, S., Liu, Z., Zhang, L., Liao, F., Yin, H., Zhao, H., Deng, Z.* and Zhang, H.* (2024) Structural basis for the activity of the type VII CRISPR-Cas system. Nature, 633, 465-472.

4. Ren, X., Sun, J., Kuang, W., Yu, F., Wang, B., Wang, Y., Deng, W., Xu, Z., Yang, S., Wang, H., Hu, Y., Deng, Z.*, Ning, Y.* and Zhao, H.* (2024) A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun, 15, 7009.

5. Kuang, W.*, Zhao, Y., Li, J. and Deng, Z.* (2024) Structure-function analysis of the ATPase domain of African swine fever virus topoisomerase. mBio, 15, e0308623.

6. Zhou, D., Cheng, R., Yao, Y., Zhang, G., Li, X., Wang, B., Wang, Y., Yu, F., Yang, S., Liu, H., Gao, G., Peng, Y., Chen, M., Deng, Z.*and Zhao, H.* (2024) An attachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection. NPJ Vaccines, 9, 158.

7. Zhao, Y., Kuang, W.*, An, Q., Li, J., Wang, Y. and Deng, Z.* (2023) Cryo-EM structures of African swine fever virus topoisomerase. mBio, 14, e0122823.

8. Yang, S., Wang, Y., Yu, F.Y., Cheng, R., Zhang, Y., Zhou, D., Ren, X., Deng, Z.* and Zhao, H.* (2023) Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun, 14, 5186.

9. Wang, X., Li, X., Yu, G., Zhang, L., Zhang, C., Wang, Y., Liao, F., Wen, Y., Yin, H., Liu, X., Wei, Y., Li, Z.*, Deng, Z.* and Zhang, H.* (2023) Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Research, 33, 699-711.

10. Yu, G., Wang, X., Zhang, Y., An, Q., Wen, Y., Li, X., Yin, H., Deng, Z.* and Zhang, H.* (2022) Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex. Nat Microbiol, 7, 2078-2088.