教育经历

2004.09-2007.07    中国科学院生物物理研究所，研究生，博士学位

2001.09-2004.06    武汉大学，研究生，硕士学位

1997.09-2001.06    武汉大学，本科，学士学位

工作经历

2014.10-至今          中国科学院武汉病毒研究所，研究员、博士生导师

学术兼职

湖北省电子显微镜学会副理事长

研究内容

1. 研究病毒膜蛋白在病毒入侵宿主细胞过程中发挥的结构与功能作用，为设计新的抗病毒药物提供靶点结构信息。

2. 依托武汉病毒所冷冻电镜研究平台，研究各种病毒的高分辨率结构。

3. 研究病毒蛋白的体外组装模型，开发具有应用前景的新型生物纳米材料。

成果（限10篇）#并列第一作者，*通讯作者）

1. Jia H#, Liu S#, Rao G, Liu Q, Wu J*, Cao S*, Gong P*. 2025. An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element. Sci Adv 11:eadv9640.

2. Hu H#, Leng C#, Shu Y#, Peng L, Wu F, Liu J, Zhang X, Zhou W, Xiao Q, Li Y, Wu B, Shen J, Li J, Gong R, Yan B, Deng F, Hu Z, Cao S*, Wang M*. 2025. Structural insights into hybridoma-derived neutralizing monoclonal antibodies against Omicron BA.5 and XBB.1.16 variants of SARS-CoV-2. J Virol:e0130724.

3. Li Z#, Xia H#, Rao G#, Fu Y, Chong T, Tian K, Yuan Z*, Cao S*. 2024. Cryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes. Nat Commun 15:2284.

4. Li H#, Zhang Y#, Rao G#, Zhang C, Guan Z, Huang Z, Li S, Lozach PY, Cao S*, Peng K*. 2024. Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication. Cell 187:6896-6913 e15.

5. Yang M#, Rao G#, Li L#, Qi L, Ma C, Zhang H, Gong J, Wei B, Zhang XE, Chen G*, Cao S*, Li F*. 2024. Transformation of a Viral Capsid from Nanocages to Nanotubes and Then to Hydrogels: Redirected Self-Assembly and Effects on Immunogenicity. ACS Nano 18:13755-13767.

6. Li L#, Chong T#, Peng L#, Liu Y, Rao G, Fu Y, Shu Y, Shen J, Xiao Q, Liu J, Li J, Deng F, Yan B, Hu Z, Cao S*, Wang M*. 2024. Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus. PLoS Pathog 20:e1011948.

7. Liu Q#, Zhao H#, Li Z#, Zhang Z#, Huang R#, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y*, Yan H*, Cao S*, Lan K*, Chen Y*. 2023. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther 8:347.

8. Yin J#, Fu Y#, Rao G#, Li Z, Tian K, Chong T, Kuang K, Wang M, Hu Z, Cao S*. 2022. Structural transitions during the cooperative assembly of baculovirus single-stranded DNA-binding protein on ssDNA. Nucleic Acids Res 50:13100-13113.

9. Li Z#, Zhang H#, Li Z, Fu Y, Wang X, Li J, Wang K, Wang Z, Zhang T, Wang M, Hu Z*, Cao S*. 2022. Structural Characterization of Per Os Infectivity Factor 5 (PIF5) Reveals the Essential Role of Intramolecular Interactions in Baculoviral Oral Infectivity. J Virol 96:e0080622.

10. Li N#, Rao G#, Li Z, Yin J, Chong T, Tian K, Fu Y, Cao S*. 2022. Cryo-EM structure of glycoprotein C from Crimean-Congo hemorrhagic fever virus. Virol Sin 37:127-137.