致力于以RNA病毒包括虫媒病毒（如寨卡病毒、发热伴血小板减少综合征病毒、蜱传脑炎病毒等）以及尼帕病毒、拉沙病毒等高致病性病毒为研究对象，聚焦病毒的感染传播与致病机制、干预手段，开展传染性病原致病机制、疫苗和抗病毒药物、动物感染模型（啮齿类和非人灵长类）及临床诊断方法等相关研究。
Zhang X#, Zhang X#, Lu J#, Yang P, Lu M, Tan S, Guo W, Hu X, Lin J*, Shan C*. The mRNA vaccine encoding Gc protein confers complete protection against severe fever with thrombocytopaenia syndrome virus. Vaccine. 2025 Aug 21;63:127631
Liu K, Rao J, Hu X, Sun H, Lu M, Zhang X, Huang F, Shan C*. Maternal Vaccination and Protective Immunity Against SARS-CoV-2 Infection in Pups. J Med Virol. 2025 May;97(5):e70418
Lu M#, Yao Y#, Liu H, Peng Y, Li X, Gao G, Chen M, Zhang X, Mao L, Yang P, Zhang X, Miao J, Yuan Z, Lan J*, Shan C*. Single-dose intranasal AdC68-vectored vaccines rapidly protect Syrian hamsters against lethal Nipah virus infection. Mol Ther. 2025 Mar 26:S1525-0016(25)00206-0
Guo W, Jiang T, Rao J, Zhang Z, Zhang X, Su J, Yin C, Lu M, Hu X, Shan C*. A safer cell-based yellow fever live attenuated vaccine protects mice against YFV infection. iScience. 2024 Sep 17;27(10):110972
Yin C, Yang P, Xiao Q, Sun P, Zhang X, Zhao J, Hu X, Shan C*. Novel antiviral discoveries for Japanese encephalitis virus infections through reporter virus-based high-throughput screening. J Med Virol. 2024 Jan;96(1):e29382
Lu M#, Yao Y#, Zhang X, Liu H, Gao G, Peng Y, Chen M, Zhao J, Zhang X, Yin C, Guo W, Yang P, Hu X, Rao J, Li E, Chen T, Chiu S, Wong G, Yuan Z*, Lan J*, Shan C*. Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection. NPJ Vaccines. 2023 Nov 4;8(1):170
Guo Y*#, Huang L#, Zhang G#, Yao Y#, Zhou H#, Shen S#, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z*, Deng F*, Zhang H*, Shan C*, Schweizer L*, Sun K*, Rao Z*. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun. 2021 May 11;12(1):2623
Shan C*#, Xia H#, Haller SL, Azar SR, Liu Y, Liu J, Muruato AE, Chen R, Rossi SL, Wakamiya M, Vasilakis N, Pei R, Fontes-Garfias CR, Singh SK, Xie X, Weaver SC*, Shi PY*. A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20190-20197
Shan C#, Yao Y#, Yang X#, Zhou Y#, Gao G, Peng Y, Yang L, Hu X, Xiong J, Jiang R, Zhang H, Gao X, Peng C, Min J, Chen Y, Si H, Wu J, Zhou P, Wang Y, Wei H, Pang W, Hu Z, Lv L, Zheng Y, Shi Z*, Yuan Z*. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res. 2020 Aug;30(8):670-677
Shi R#, Shan C#, Duan X#, Chen Z#, Liu P#, Song J, Song T, Bi X, Han C, Wu L, Gao G, Hu X, Zhang Y, Tong Z, Huang W, Liu WJ, Wu G, Zhang B, Wang L, Qi J, Feng H, Wang FS*, Wang Q*, Gao GF*, Yuan Z*, Yan J*. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature. 2020 Aug;584(7819):120-124
