教育经历

2009/09-2014/07    中国农业大学，微生物，博士学位

2005/09-2009/06    河北科技大学，生物技术，学士学位

工作经历

2021/03-至今           武汉大学生命科学学院，病毒学国家重点实验室，研究员

2020/01-2021/02    美国圣路易斯华盛顿大学医学院，讲师

2015/02-2019/12    美国圣路易斯华盛顿大学医学院，博士后

学术兼职

2024.10-至今           湖北省微生物学会-病毒专委会委员

2020.07-至今           Frontiers in Cellular and Infection Microbiology杂志，Review Editor

2022.02-至今           Viruses杂志，Guest Editor

研究内容

课题组主要以虫媒病毒以及各种新发与再发传染性病毒为研究对象，结合分子病毒学、细胞生物学、生物化学和结构生物学等多种技术手段，研究病毒感染诱导的体液免疫应答特点和机制，开发高效保护性抗体药物，并进行抗原的优化设计和疫苗的研发。

主持项目

2026-2029               国家自然科学基金面上项目，主持

2022-2025               国家自然科学基金面上项目，主持

2022-2025               国家重点研发计划“生物安全关键技术研究”重点专项，课题负责人

2025-2028               湖北省青年A类项目，主持

2024-2027               国家重点研发计划“生物安全关键技术研究”重点专项，骨干

成果（限10篇）#并列第一作者，*通讯作者）

1. Ren X^#, Sun J^#, Kuang W^#, Yu F, Wang B, Wang Y, Deng W, Xu Z, Yang S, Wang H, Hu Y, Deng Z*, Ning YJ*, Zhao H*. A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun. 2024; 15(1):7009.

2. Zhou D^#, Cheng R^#, Yao Y^#, Zhang G, Li X, Wang B, Wang Y, Yu F, Yang S, Liu H, Gao G, Peng Y, Chen M, Deng Z*, Zhao H*. An attachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection. npj Vaccines. 2024; 9(1):158.

3. Yang S^#, Wang Y^#, Yu F^#, Cheng R, Zhang Y, Zhou D, Ren X, Deng Z*, Zhao H*. Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun. 2023;14(1):5186.

4. Zhao H#, Fernandez E#, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS*, Fremont DH*. Structural Basis of Zika Virus-Specific Antibody Protection. Cell. 2016; 166:1016-1027.

5. Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH*. Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 2020; 217:e20191792.

6. Liu Q^#, Zhao H^#, Li Z^#, Zhang Z^#, Huang R^#, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y*, Yan H*, Cao S*, Lan K*, Chen Y*. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther. 2023;8(1):347.

7. Errico JM#, Zhao H#, Chen RE, Liu Z, Case JB, Ma MS, Schmitz AJ, Rau MJ, Fitzpatrick JA, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH *, 2021. Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Cell Reports, 2021；37 (4) 109881.

8. Alsoussi WB#, Turner JS#, Case JB#, Zhao H#, Schmitz AJ#, Zhou JQ#, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH*. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. J Immunol. 2020;ji2000583. #Co-first authors.

9. Zhao H, Guo XK, Bi Y, Zhu Y, Feng WH*. PKCδ is required for porcine reproductive and respiratory syndrome virus replication. Virology. 2014;468-470:96-103.

10. Zhao H, Wang Y, Ma Z, Wang Y, Feng WH*. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 2014;15:199-208.

奖励

2021，武汉市“武汉英才”优秀青年人才

2020，湖北省“百人计划”创新人才