中文简历

教育经历

2005-2009：美国克利夫兰临床医院，分子病毒学，博士后。

2002-2005：法国里昂第一大学，感染与免疫，博士后。

1996-2002：华中农业大学，微生物学，博士。

1992-1996：华中农业大学，土壤化学，学士。

工作经历

2009-至今：武汉生物生命科学学院，教授。

2009-至今：病毒学国家重点实验室，教授。

学术兼职

1. 美国微生物学会，会员。

2. 美国病毒学学会，会员。

3. 中国微生物学会，委员。

4. 湖北生物工程学会，常务理事。

    

   研究内容

   以两个感染婴幼儿的主要病原：人副流感病毒（引起呼吸道感染的主要病原）和EV71（引起手足口病的主要病原）为模式病毒，研究RNA病毒的感染和致病机制，重点解析病毒的转录、复制和包装的分子机制；揭示病毒与宿主细胞的相互作用网络、病毒拮抗宿主细胞的免疫反应和免疫逃逸的分子机制；开展新型抗EV71和人副流感病毒疫苗的研发。

    

   主持项目

   主持国家自然科学基金面上（2项）和重点项目（1项）；新世纪优秀人才支持计划；湖北省杰出青年科学基金；参与国家科技部973计划项目（1项目）。

    

   成果

       自2009年底在武汉大学建立实验室以来，以独立通讯作者在《细胞》子刊Cell Host & Microbe（1篇）、Journal of Virology（5篇）、WIREs RNA（1篇）和Vaccine（1篇）等国际权威期刊发表论文多篇。

   代表性成果（*通讯作者)

1. Zhang S, Jiang Y, Cheng Q, ZhongY, Qin Y, ChenM*.  Inclusion body fusion ofhuman parainfluenza virus type 3 regulated by acetylated α-tubulin enchancesviral replication. Journal of Virology (Accepted).

2. Jiang Y, Qin Y*, ChenM*. 2016. Host-Pathogen Interactions in Measles Virus Replication and Anti-ViralImmunity.. Viruses, 8 (11), E308 (Invitedreview).

3. Yan Q, Wu L, Chen L, Qin Y*, Pan Z*, ChenM*. 2016.Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particleselicit strong immune responses and protect new born mice from lethalchallenges. Vaccine. 34:4196-4204.

4. ZhangG,ZhongY,Qin Y, ChenM*. 2016.Interaction of Human Parainfluenza Virus Type 3 Nucleoprotein with MatrixProtein Mediates Internal Viral Protein Assembly. Journal of Virology.90(5):2306-15.

5. Ding B, Qin Y, ChenM*.2016. Nucleocapsid proteins: rolesbeyond viral RNA packaging. WIREs RNA. 7(2):213-26. (Invited review).

6. Chen L, Zhong Y,Hu Z, Qin Y. Chen M. ChenM*. 2016.Twosecond-site mutations compensate the engineered mutation of R7A in vesicularstomatitis virus nucleocapsid protein. Virus Research, 214:59-64.

7. Chen L, Yan Q, Lu G, Hu Z, ZhangG, Zhang S, Ding B, Jiang Y, Zhong Y, Gong P, Chen M*. 2015. Severalresidues within the N-terminal arm of vesicular stomatitis virus nucleoproteinplay a critical role in protecting viral RNA from nuclease digestion. Virology.478:9-17.

8. DingB,YangX,ZhangS,ChenL,ZhangG,YanQ,BanerjeeAK,ChenM*.2014.Phosphoproteinofhumanparainfluenzavirustype3blocksautophagosome-lysosomefusiontoincreasevirusproduction. CellHost&Microbe.15(5):564-77.

9. ZhangG,ZhangS,DingB,YangX,ChenL,YanQ,JiangY,ZhongY,ChenM*.2014. ALeucineResidueinC-terminusofHumanParainfluenzaVirusType3MatrixProteinIsEssentialforEfficientVirus-LikeParticleandVirionRelease.JournalofVirology.88(22):13173-88.

10. Zhang S, Chen L, Zhang G, Yan Q,Yang X, Ding B, Tang Q, Sun S, Hu Z, ChenM*. 2013. An amino acid of human parainfluenza virus type 3nucleoprotein is critical for template function and cytoplasmic inclusion bodyformation. Journal of Virology. 87(22):12457-70.

11. Chen L, Zhang S, Banerjee AK and Chen M*. 2013. N-Terminal Phosphorylation of Phosphoprotein ofVesicular Stomatitis Virus Is Required for Preventing Nucleoprotein fromBinding to Cellular RNAs and for Functional Template Formation. Journal of Virology. 87(6):3177-86.

12. ChenM, Ogino T, Banerjee AK*. 2007. Interaction of vesicular stomatitis virus P and N proteins:Identification of two overlapping domains at the N-terminus of P that areinvolved in N0-P complex formation and encapsidation of viral genome RNA. Journal of Virology. 81(24):13478-85.

13. Chen M, Ogino T, BanerjeeAK*. 2006. Mapping and functional role ofthe self-association domain of vesicular stomatitis virus phosphoprotein. Journal of Virology. 80(19): 9511-8.

14. Chen M and Gerlier D*. 2006.Viral Hijacking of Cellular Ubiquitination Pathways as anAnti-Innate Immunity Strategy. Viral Immunology. 19(3): 347-348.

15. Chen M, Cortay JC, Logan IR,Sapountzi V, Robson CN, Gerlier D*. 2005. Inhibition of ubiquitination and stabilization of humanubiquitin E3 ligase PIRH2 by measles virus phosphoprotein. Journal of Virology. 79(18): 11824-36