教育经历

2010.09-2014.06     中国科学院武汉病毒研究所，研究生，博士学位；

2007.09-2010.06     福建农林大学，            研究生，硕士学位；

2003.09-2007.06     青岛农业大学，             本科， 学士学位。

工作经历

2023年-至今               中国科学院生物安全模式实验室，主任；

2022年-至今                  中国科学院武汉国家生物安全实验室（P4），副主任；

2019年-至今               中国科学院武汉病毒研究所，研究员、学科组长；

2015年-2019年             得克萨斯大学医学部（美国），博士后

2013年-2015年             诺华热带疾病研究所（新加坡），科研助理。

学术兼职

无 

研究内容

致力于以RNA病毒包括虫媒病毒（如寨卡病毒、发热伴血小板减少综合征病毒、蜱传脑炎病毒等）以及尼帕病毒等高致病性病毒为研究对象，聚焦虫媒病毒的感染传播与致病机制，开展疫苗、动物感染模型（小鼠和非人灵长类）及临床诊断方法等相关研究。

主持项目

1.         海外人才引进计划

项目名称：国家海外高层次人才计划

执行年限：2021-2024

承担角色：负责人

资助金额：3,000,000人民币

2.        国家重点研发计划（基金号：2020YFC0842100）

项目名称：2019-nCoV 灭活疫苗

执行年限：2020

承担角色：课题负责人

资助金额：1,000,000人民币

3.        中国科学院STS计划区域重点项目（基金号：KFJ-STS-QYZD-2021-12-001）

课题名称：新型冠状病毒灭活疫苗的研发

执行年限：2021-2022

承担角色：课题负责人

资助金额：4,500,000人民币

4.         武汉市人才引进

项目名称：武汉英才

执行年限：2022-2023

承担角色：项目负责人

资助金额：200,000人民币

5.         中国科学院武汉病毒研究所“青年突击队”攻关项目（基金号：2022QNTJ-04）

项目名称：CCHFV拮抗宿主抗病毒应答机制的研究、药物筛选系统和疫苗研发

执行年限：2022-2023

承担角色：项目负责人

资助金额：500,000人民币

6.         企业合作项目

名称：新冠mRNA疫苗恒河猴体内药效学评价

执行年限：2022-2027

承担角色：项目负责人

资助金额：4,180,000人民币

成果

1.         Lu J, Tan S, Gu H, Liu K, Huang W, Yu Z, Lu G, Wu Z, Gao X, Zhao J, Yao Z, Yi F, Yang Y, Wang H, Hu X, Lu M, Li W, Zhou H, Yu H, Shan C, Lin J. Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies. Emerg Microbes Infect. 2024 Dec;13(1):2321994. doi:10.1080/22221751.2024.2321994. Epub 2024 Feb 29. PMID: 38377136; PMCID:PMC10906132.

2.         Yin C, Yang P, Xiao Q, Sun P, Zhang X, Zhao J, Hu X, Shan C. Novel antiviral discoveries for Japanese encephalitis virus infections through reporter virus-based high-throughput screening. J Med Virol. 2024 Jan;96(1):e29382. doi:10.1002/jmv.29382. PMID: 38235833.

3.         Lu M, Yao Y, Liu H, Zhang X, Li X, Liu Y, Peng Y, Chen T, Sun Y, Gao G, Chen M, Zhao J, Zhang X, Yin C, Guo W, Yang P, Hu X, Rao J, Li E, Wong G, Yuan Z, Chiu S, Shan C, Lan J . Vaccines based on the fusion protein consensus sequence protect Syrian hamsters from Nipah virus infection. JCI Insight. 2023 Dec 8;8(23):e175461. doi: 10.1172/jci. insight. 175461.

4.         Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J. 2023. Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing) 14:S2095-9273(23)00778-8. doi: 10.1016/j.scib.2023.11.024. Online ahead of print.

5.         Lu M, Yao Y, Zhang X, Liu H, Gao G, Peng Y, Chen M, Zhao J, Zhang X, Yin C, Guo W, Yang P, Hu X, Rao J, Li E, Chen T, Chiu S, Wong G, Yuan Z, Lan J, Shan C. Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection.NPJ Vaccines. 2023 Nov 4;8(1):170. doi: 10.1038/s41541-023-00762-3.

6.         Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, Zhang X, Hu X, Yang C, Zhong G,Zhang R, Wang X, Shan C, Ding Q. Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. mBio. 2023 Apr 3:e0041623. doi: 10.1128/mbio.00416-23. Epub ahead of print. PMID: 37010428.

7.         Wang Z, An J, Liu K, Yu P, Fang X, Li J, Zhu H, Zhu Q, Huang C, Zhang C, Zhao B, Bao L, Song Y, Cao X, Hu D, Jiang Y, Shi L, Zhou L, Fan J, Guan W, Zhou C, Hu Z, Yuan Z, Liu J, Shan C, Liu G. A potent, broadly protective vaccine against SARS-CoV-2 variants of concern. NPJ Vaccines. 2022 Nov 12;7(1):144. doi: 10.1038/s41541-022-00571-0. PMID: 36371432; PMCID: PMC9653380.

8.         Lu M, Liu K, Peng Y, Ding Z, Li Y, Tendu A, Hu X, Gao G, Guo W, Liu H, Rao J, Zhao J, Chen M, Yuan Z, Wong G, Shan C, Yao Y, Lan J. Recombinant chimpanzee adenovirus vector vaccine expressing the spike protein provides effective and lasting protection against SARS-CoV-2 infection in mice. Virol Sin. 2022 Aug;37(4):581-590. doi: 10.1016/j.virs.2022.05.006. Epub 2022 Jun 1. PMID: 35659605; PMCID: PMC9156438.

9.         Gao G, Hu X, Zhou Y, Rao J, Zhang X, Peng Y, Zhao J, Yao Y, Liu K, Liang M, Liu H, Deng F, Xia H, Shan C, Yuan Z. Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque. Virol Sin. 2022 Apr;37(2):299-302. doi: 10.1016/j.virs.2022.02.001. Epub 2022 Feb 10. PMID: 35279412; PMCID: PMC8828374.

10.     Pan X, Shi J, Hu X, Wu Y, Zeng L, Yao Y, Shang W, Liu K, Gao G, Guo W, Peng Y, Chen S, Gao X, Peng C, Rao J, Zhao J, Gong C, Zhou H, Lu Y, Wang Z, Hu X, Cong W, Fang L, Yan Y, Zhang J, Xiong H, Yi J, Yuan Z, Zhou P, Shan C, Xiao G. RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates. Cell Discov. 2021 Sep 7;7(1):82. doi: 10.1038/s41421-021-00320-y. PMID: 34493710; PMCID: PMC8423076.

11.     Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, Pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, Peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao Z. A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun. 2021 May 11;12(1):2623. doi: 10.1038/s41467-021-22926-2. PMID: 33976198; PMCID: PMC8113581.

12.     Yao YF, Wang ZJ, Jiang RD, Hu X, Zhang HJ, Zhou YW, Gao G, Chen Y, Peng Y, Liu MQ, Zhang YN, Min J, Lu J, Gao XX, Guo J, Peng C, Shen XR, Li Q, Zhao K, Yang L, Wan X, Zhang B, Wang WH, Wu J, Zhou P, Yang XL, Shen S, Shan C, Yuan ZM, Shi ZL. Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates. Virol Sin. 2021 Oct;36(5):879-889. doi: 10.1007/s12250-021-00376-w. Epub 2021 Apr 9. PMID: 33835391; PMCID: PMC8034048.

13.     Feng L, Wang Q, Shan C, Yang C, Feng Y, Wu J, Liu X, Zhou Y, Jiang R, Hu P, Liu X, Zhang F, Li P, Niu X, Liu Y, Zheng X, Luo J, Sun J, Gu Y, Liu B, Xu Y, Li C, Pan W, Zhao J, Ke C, Chen X, Xu T, Zhong N, Guan S, Yuan Z, Chen L. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nat Commun. 2020 Aug 21;11(1):4207. doi: 10.1038/s41467-020-18077-5. PMID: 32826924; PMCID: PMC7442803.

14.     Shan C, Xia H, Haller SL, Azar SR, Liu Y, Liu J, Muruato AE, Chen R, Rossi SL, Wakamiya M, Vasilakis N, Pei R, Fontes-Garfias CR, Singh SK, Xie X, Weaver SC, Shi PY. A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20190-20197. doi: 10.1073/pnas.2005722117. Epub 2020 Aug 3. PMID: 32747564; PMCID: PMC7443865.

15.     Shan C, Yao YF, Yang XL, Zhou YW, Gao G, Peng Y, Yang L, Hu X, Xiong J, Jiang RD, Zhang HJ, Gao XX, Peng C, Min J, Chen Y, Si HR, Wu J, Zhou P, Wang YY, Wei HP, Pang W, Hu ZF, Lv LB, Zheng YT, Shi ZL, Yuan ZM. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. Cell Res. 2020 Aug;30(8):670-677. doi: 10.1038/s41422-020-0364-z. Epub 2020 Jul 7. PMID: 32636454; PMCID: PMC7364749.

16.     Shi R, Shan C, Duan X, Chen Z, Liu P, Song J, Song T, Bi X, Han C, Wu L, Gao G, Hu X, Zhang Y, Tong Z, Huang W, Liu WJ, Wu G, Zhang B, Wang L, Qi J, Feng H, Wang FS, Wang Q, Gao GF, Yuan Z, Yan J. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature. 2020 Aug;584(7819):120-124. doi: 10.1038/s41586-020-2381-y. Epub 2020 May 26. PMID: 32454512.

17.     Chao Shan, Xuping Xie, Huanle Luo, Antonio E Muruato, Yang Liu, Maki Wakamiya, Jun-Ho La, Jin Mo Chung, Scott C Weaver, Tian Wang, Pei-Yong Shi. Maternal vaccination and protective immunity against Zika virus vertical transmission. Nat. Commun. 2019; 10(1): 1-12.

18.     Antonio E Muruato, Chao Shan, Camila R Fontes-Garfias, Yang Liu, Zengguo Cao, Qiang Gao, Scott C Weaver, Pei-Yong Shi. Genetic stability of live-attenuated Zika vaccine candidates. Antiviral research. 2019, 171: 104596.

19.     Chao Shan, Xuping Xie, Jing Zou, Roland Züst, Bo Zhang, Rebecca Ambrose, Jason Mackenzie, Katja Fink, Pei-Yong Shi. Using a virion assembly-defective dengue virus as a vaccine approach. J Virol. 2018 Aug 15. pii: JVI.01002-18.

20.     Chao Shan, Xuping Xie, Pei-Yong Shi. Zika Virus Vaccine: Progress and Challenges. Cell Host and Microbe. 2018, doi.org/10.1016/j.chom.2018.05.021.

21.     Hongjie Xia, Xuping Xie, Chao Shan, and Pei-Yong Shi. Potential Mechanisms for Enhanced Zika Epidemic and Disease. ACS Infect Dis. 2018, 4 (5), pp 656–659.

22.     Camila R. Fontes-Garfias, Chao Shan, Huanle Luo, Antonio E. Muruato, Daniele B.A. Medeiros, Elizabeth Mays, Xuping Xie, Jing Zou, Christopher M. Roundy, Maki Wakamiya, Shannan L. Rossi, Tian Wang, Scott C. Weaver, Pei-Yong Shi. Functional Analysis of Glycosylation of Zika Virus Envelope Protein. Cell Rep. 2017; 21(5): 1180-1190.

23.     Chao Shan, Antonio E. Muruato, Brett W. Jagger, Justin Richner, Bruno T.D. Nunes, Daniele B.A. Medeiros, Xuping Xie, Jannyce G.C. Nunes, Kaitlyn M. Morabito, Wing-Pui Kong, Theodore C. Pierson, Alan D. Barret, Scott C. Weaver, Shannan L. Rossi, Pedro F.C. Vasconcelos, Barney S. Graham*, Michael S. Diamond*, Pei-Yong Shi*. A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage. Nat. Commun. 2017; 8(1): 676.

24.     Chao Shan, Daniel A. Ortiz, Yujiao Yang, Susan J. Wong, Laura D. Kramer, Pei-Yong Shi, Michael J. Loeffelholz, Ping Ren. Evaluation of a Novel Reporter Virus Neutralization Test for the Serological Diagnosis of Zika and Dengue Virus Infection. J Clin Microbiol. 2017; 55(10): 3028-3036.

25.     Justin M. Richner, Brett W. Jagger, Chao Shan, Camila R. Fontes, Kimberly A. Dowd, Bin Cao, Sunny Himansu, Elizabeth A. Caine, Bruno T.D. Nunes, Daniele B.A. Medeiros, Antonio E. Muruato, Bryant M. Foreman, Huanle Luo, Tian Wang, Alan D. Barrett, Scott C. Weaver, Pedro F.C. Vasconcelos, Shannan L. Rossi, Giuseppe Ciaramella, Indira U. Mysorekar, Theodore C. Pierson, Pei-Yong Shi, Michael S. Diamond. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. Cell 2017; 170(2): 273-283.e12.

26.     Yang Liu, Jianying Liu, Senyan Du, Chao Shan, Kaixiao Nie, Xiaofeng Li, Tao Wang, Cheng-Feng Qin, Penghua Wang, Pei-Yong Shi, Gong Cheng. Evolutionary enhancement of Zika virus infectivity in mosquitos. Nature 2017; 545(7655): 482-486.

27.     Chao Shan, Antonio E. Muruato, Bruno T.D. Nunes, Huanle Luo, Xuping Xie, Daniele B.A. Medeiros, Robert B. Tesh, Alan D. Barrett, Tian Wang, Scott C. Weaver, Pedro F.C. Vasconcelos, Shannan L. Rossi, Pei-Yong Shi. A live-attenuated Zika virus vaccine induces sterilizing immunity in mouse models. Nat Med. 2017; 23(6): 763-767.

28.     Chao Shan, Xuping Xie, Ping Ren, Michael J. Loeffelholz, Yujiao Yang, Andrea Furuya, Alan P. Dupuis II, Laura D. Kramer, Susan J. Wong, and Pei-Yong Shi, A rapid Zika diagnostic assay to measure neutralizing antibodies in patients. EBioMedicine 2017; 17:157-162.

29.     Yujiao Yang, Chao Shan, Jing Zou, Antonio E. Muruato, Diniz Nunes Bruno, Barbosade Almeida Medeiros Daniele, Pedro F.C. Vasconcelos, Shannan L.Rossi, Scott C. Weaver, Xuping Xie, Pei-Yong Shi. A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine. EBioMedicine 2017;17: 145-156

30.     Chao Shan, Xuping Xie, Antonio E. Muruato, Shannan L. Rossi, Christopher M. Roundy, Sasha R. Azar, Yujiao Yang, Robert B. Tesh, Nigel Bourne, Alan D. Barrett, Nikos Vasilakis, Scott C. Weaver, and Pei-Yong Shi, An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors. Cell Host Microbe 2016; 19(6): 891-900.

31.     Chao Shan, Xuping Xie, Alan D. T. Barrett, Mariano A. Garcia-Blanco, Robert B. Tesh, Pedro Fernando da Costa Vasconcelos, Nikos Vasilakis, Scott C. Weaver, and Pei-Yong Shi. Zika Virus: Diagnosis, Therapeutics, and Vaccine. ACS Infect Dis. 2016; 2(3): 170-2.

32.     Cheng Chen, Yaxin Wang, Chao Shan, Yuna Sun, Peng Xu, Honggang Zhou, Cheng Yang, Pei-Yong Shi, Zihe Rao, Bo Zhang, Zhiyong Lou. Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation. J Virol. 2013, 87 (10): 5755-5768.

33.     Chao Shan, Xiaodan Li, Chenglin Deng, Baodi Shang, Linlin Xu, Hanqing Ye, Zhiming Yuan and Bo Zhang. Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase. Virol Sin. 2013, 28 (3):161-166.

34.     Yuna Sun, Yaxin Wang, Chao Shan, Cheng Chen, Peng Xu, Mohan Song, Honggang Zhou, Cheng Yang, Wenbo Xu, Pei-Yong Shi, Bo Zhang, Zhiyong Lou. Entrovirus-71 VPg uridylation uses a two-molecular mechanism of 3Dpol. J Virol. 2012, 86(24):13662-13671 

奖励

2023年 获得湖北青年五四奖章

2021年 获得武汉英才称号

2021年 获得湖北省科技进步特等奖（参与）

2020年 获得中国科学院武汉病毒所青年年度人物

2017年 获得ACS Infectious Diseases Young Investigator Award

2017年 获得American Society for Virology Postdoctoral Fellow Travel Award

2012年 获得博士研究生国家奖学金