中文简历

教育经历

2010.09-2018.06，中国科学院上海巴斯德研究所，微生物学，博士。

2005.09-2009.06，青岛农业大学，生物科学，学士

工作经历

2020 -至今，武汉大学，生命科学学院，病毒学国家重点实验室，副研究员

2018-2019，武汉大学，生命科学学院，病毒学国家重点实验室，研究助理

研究内容

主要从事卡波氏肉瘤相关疱疹病毒（KSHV）生命周期调控及致病机理的研究，在KSHV病毒重要功能蛋白与宿主蛋白互作、病毒蛋白的翻译后修饰、解旋酶的氧化修饰等方面做出了重要的原创性工作，论文主要发表在Cell Research、Science Advances、Plos Pathogens、Clinical Epidemiology、Journal of Virology等学术期刊。

主持项目

国家自然科学基金面上项目（基金号：82172265）

课题名称: 磷酸酶PP2A调控KSHV再激活的功能机制研究

执行年限2022-2025

承担角色:主持人

资助金额:550,000元人民币

成果

(1)        Lianghui Dong^#, Jiazhen Dong^#, Min Xiang, Ping Lei, Zixian Li, Fang Zhang, Xiaoyi Sun, Danping Niu, Lei Bai*, Ke Lan*; NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase, PLoS Pathogens, 2021 Jun 2;17(6): e1009645.

(2)        Lei Bai^#, Yongliang Zhao^#, Jiazhen Dong^#, Simeng Liang^#, Ming Guo^#, Xinjin Liu, Xin Wang, Zhixiang Huang, Xiaoyi Sun, Zhen Zhang, Lianghui Dong, Qianyun Liu, Yucheng Zheng, Danping Niu, Min Xiang, Kun Song, Jiajie Ye, Wenchao Zheng, Zhidong Tang, Mingliang Tang, Yu Zhou, Chao Shen, Ming Dai, Li Zhou, Yu Chen, Huan Yan, Ke Lan*, Ke Xu*; Coinfection with influenza A virus enhances SARS-CoV-2 infectivity, Cell Research, 2021 Feb 18;1-9.

(3)        Bai L^#, Dong J^#, Liu Z^#, Rao Y^#, Feng P*, Lan K*; Viperin catalyzes methionine oxidation to promote protein expression and function of helicases, Science Advances, 2019 Aug 28;5(8): eaax1031.

(4)        Wei Xiaoqin^#, Bai Lei^#, Dong Lianghui, Liu Huimei, Xing Peidong, Zhou Zhiyao, Wu Shuwen, Lan Ke*; NCOA2 promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus by enhancing the expression of the master switch protein RTA, PLoS Pathogens, 2019, 15(11): 0-e1008160.

(5)        Bai Lei^#, Liu Zhenqiu^#, Fang Qiwen, Yan Qiong, Shi Oumin, Bao Pingping, Mu Lina, Chen Xingdong*, Zhang Tiejun*; The trends and projections in the incidence and mortality of liver cancer in urban Shanghai: a population-based study from 1973 to 2020, Clinical Epidemiology, 2018, 10:277-288.

(6)        Wei X^#, Dong J^#, Cheng CC, Ji M, Yu L, Luo S, Wu S, Bai L, Lan K*; Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45, PLoS Pathogens, 2020 Dec 14;16(12): e1009099.

(7)        Fei Yuan^#, Zeng-Qiang Gao^#, Vladimir Majerciak^#, Lei Bai, Meng-Lu Hu, Xiao-Xi Lin, Zhi-Ming Zheng, Yu-Hui Dong*, Ke Lan*; The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function, PLoS Pathogens, 2018 Aug 10;14(8): e1007232.

(8)        Li S, Bai L, Dong J, Sun R, Lan K*; Kaposi’s Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology, Adv Exp Med Biol, 2017;1018:91-127.

(9)        Hu H^#, Dong J^#, Liang D^#, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*; Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor, Journal of Virology, 2015 Nov 4;90(3):1158-68.

(10)     Wan Liu, Yan Qin, Lei Bai, Ke Lan, Jian-Hua Wang*; Kaposi's-sarcoma-associated-herpesvirus-activated dendritic cells promote HIV-1 trans-infection and suppress CD4(+) T cell proliferation, Virology, 2013 Jun 5;440(2):150-9.