教育经历

1999.09-2004.06      武汉大学生命科学学院，研究生，博士学位

1995.09-1999.06      武汉大学生命科学学院，本科，学士学位；

工作经历

2021-至今     武汉大学生命科学学院病毒学系，教授

病毒学国家重点实验室，固定研究人员

2006-2021     武汉大学生命科学学院病毒学系，副教授

病毒学国家重点实验室，固定研究人员

2004-2006     武汉大学生命科学学院病毒学系，讲师

学术兼职

中国微生物学会病毒学专业委员会，青年委员

湖北省生物工程学会，理事

研究内容（限200字）

以病毒感染与致病的分子机制为研究重点，进行病毒感染、复制、免疫逃逸及导致炎症的分子机理研究；同时进行致病病原的监测、分离、培养和鉴定工作。

主持项目（限10项）

1. 国家“十三五”“重大传染病防治”科技重大专项（项目编号：2017ZX10103005）

课题名称：湖北及周边省传染病病原谱和流行规律研究

执行年限：2017-2020

承担角色：项目负责人

资助金额：2130.38万元

2. 国家863目标导向课题（项目编号：2007AA02Z156）

课题名称: 溶瘤单纯疱疹病毒mtHSV安全性关键技术及临床应用研究

执行年限:2007-2010

承担角色:项目负责人

资助金额: 298万元

3. 国家自然科学基金面上项目（项目编号：81871251）

课题名称：干扰素刺激基因15对NLRP3炎症小体及相关炎症性疾病的调控功能与机制研究

执行年限：2019-2022

承担角色：项目负责人

资助金额：57万元

成果（限40篇）

1.         Wang W, Li G, De Wu, Luo Z, Pan P, Tian M, Wang Y, Xiao F, Li A, Wu K, Liu X, Rao L, Liu F*, Liu Y*, Wu J*. Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleuin-1β secretion. Nat Commun. 2018 Jan 9;9(1):106. doi: 10.1038/s41467-017-02645-3.

2.         Luo Z, Ge M, Chen J, Geng Q, Tian M, Qiao Z, Bai L, Zhang Q, Zhu C, Xiong Y, Wu K, Liu F*, Liu Y*, Wu J*. HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection. PLoS Pathog. 2017 Aug 30;13(8):e1006585. doi: 10.1371/journal.ppat.1006585. eCollection 2017 Aug.

3.         Zhang XW, Zhu CL, Jiang H, Ren YH, Zhang Q, Wu KL, Liu F*, Liu YL*, Wu JG*. GP73 Represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PLoS Pathog 2017. PLoS Pathog. 2017 Apr 10;13(4):e1006321. doi: 10.1371/journal.ppat.1006321. eCollection 2017 Apr.

4.         Wang WB#, Xiao F#, Wan P, Pan P, Zhang YC, Liu F, Wu KL, Liu YL*, Wu JG*. EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex. EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex. PLoS Pathog 2017; 13(1):e1006123. (IF:7.003)

5.         Wan P, Zhang Q, Liu W, Jia Y, Ai S, Wang T, Wang W, Pan P, Yang G, Xiang Q, Huang S, Yang Q, Zhang W, Liu F, Tan Q, Zhang W, Wu K*, Liu Y* & Wu J*. Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation. FASEB J. 2019 Apr; 33(4), 5793-5807, doi:10.1096/fj.201801681R.

6.         Xu W, Ma C, Zhang Q, Zhao R, Hu D, Zhang X, Chen J, Liu F, Wu K, Liu Y*, Wu J*.PJA1 Coordinates with the SMC5/6 Complex to Restrict DNA Viruses and Episomal Genes through Interferon-independent Manner. J Virol. 2018 Sep 5. pii: JVI.00825-18. doi: 10.1128/JVI.00825-18.

7.         Chen JB, Xu W, Chen YN, Xie XP, Zhang YC, Ma CQ, Yang QY, Han Y, Zhu CL, Xiong Y, Liu F, Wu KL, Liu YL*, Wu JG*. MMP-9 facilitates hepatitis B virus replication through binding with IFNAR1 to repress IFN/JAK/STAT signaling. J Virol 2017; 91(8):e01824-16.

8.         Ge M, Luo Z, Qiao Z, Zhou Y, Cheng X, Geng Q, Cai Y, Wan P, Xiong Y, Liu F, Wu K*, Liu Y*, Wu J*. HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. J Immunol. 2017 Nov 1;199(9):3280-3292. doi: 10.4049/jimmunol.1700376. Epub 2017 Sep 27.

9.         Wang K, Li S, Gao Y, Feng X, Liu W, Luo R, Song Y, JiTu, Liu Y*, Yang C*. BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages. Bone. 2018 Jun 19. pii: S8756-3282(18)30247-3. doi: 10.1016/j.bone.2018.06.015.

10.     Liu Z, Dai X, Wang T, Zhang C, Zhang W, Zhang W, Zhang Q, Wu K, Liu F, Liu Y*, Wu J*. Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. Cancer Lett. 2017 Aug 1;400:149-160. doi: 10.1016/j.canlet.2017.04.017. Epub 2017 Apr 25.

11.     Yu Y, Wan P, Cao Y, Zhang W, Chen J, Tan L, Wang Y, Sun Z, Zhang Q, Wan Y, Zhu Y, Liu F, Wu K, Liu Y*, Wu J*. Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. Sci Rep. 2017 May 11;7(1):1729. doi: 10.1038/s41598-017-01773-6.

12.     Wang K, Liu W, Song Y, Wu X, Zhang Y, Li S, Gao Y, Tu J, Liu Y*, Yang C*. The role of angiopoietin-2 in nucleus pulposus cells during human intervertebral disc degeneration. Lab Invest. 2017 Aug;97(8):971-982. doi: 10.1038/labinvest.2017.35. Epub 2017 Apr 10.

13.     Zhang W, Han DJ, Wan P, Pan P, Cao YH, Liu YL*, Wu LK*, Wu JG*. ERK/c-Jun recruits Tet1 to induce Zta expression and Epstein-Barr virus reactivation through DNA demethylation. Sci Rep 2016; 6:34543.

14.     Han Y, Wang LY, Cui J, Song Y, Luo Z, Chen JB, Xiong Y, Zhang Q, Liu F, Ho WZ, Liu YL*, Wu KL*, Wu JG*. SIRT1 inhibits EV71 genome replication and RNA translation by interfering with the viral polymerase and 5’UTR RNA. J Cell Sci 2016; 129:4534-4547.

15.     Zhang XW, Wang TC, Dai XC, Zhang YC, Jiang H, Zhang Q, Liu F, Wu KL, Liu YL*, Zhou H*, Wu JG*. Golgi protein 73 facilitates the interaction of hepatitis C virus NS5A with apolipoprotein E to promote viral particle secretion. Biochem Biophys Res Commun 2016; 479(2016):683-689.

16.     Liu J, Ai H, Xiong Y, Li F, Wen Z, Liu W, Li T, Qin K, Wu JG*, Liu YL*. Prevalence and correlation of infectious agents in hospitalized children with acute respiratory tract infections in central China. PLoS One 2015; 10(3):e0119170.

17.     Liu WY, Wu SM, Xiong Y, Li TY, Wen Z, Yan MZ, Qin K, Liu YL*, Wu JG*.  Co-circulation and genomic recombination of coxsackievirus A16 and enterovirus 71 during a large outbreak of hand, foot, and mouth disease in central China. PLoS One 2014; 9(4):e96051.

18.     Zou T, Ouyang L, Chen L, Dong W, Qiao H, Liu YL*, Qi YP*. The role of microtubule-associated protein 1S in SOCS3 regulation of IL-6 signaling. FEBS Lett 2008; 582(29):4015-22.

19.     Chen L, Dong W, Zou T, Ouyang L, He G, Liu YL*, Qi YP*. Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6. FEBS Lett 2008; 582(19):2843-2849.

20.     Wan Q, Kuang E, Dong W, Zhou S, Xu H, Qi YP, Liu YL*. Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress. Apoptosis 2007; 12(2):319.

21.     Xiang R#, Liu YL#, Zhu L, Dong W, Qi YP*. Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes. Apoptosis 2006; 11(11):1923-1932.

22.     Zhu H, Su Y, Zhou S, Xiao W, Ling W, Hu B, Liu YL*, Qi YP*. Immune analysis on mtHSV mediated tumor therapy in HSV-1 seropositive mice. Cancer Biol Ther 2007; 6(5):724-731.

23.     Su Y, Zhu H, Xiao W, Xu Q, Zhu L, Zhang X, Wan Q, Zhou S, Du E, Xu H, Yao L, Lv S, Hu B, Liu YL*, Qi YP*. Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3. Cancer Biol Ther 2007; 6(2):202-208.

24.     Peng J, Dong W, Chen L, Zou T, Qi YP*, Liu YL*. Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation. Mol Cell Biochem 2007; 294(1-2):45-54.

25.     Xu Q, Zhang P, Hu C, Liu X, Qi YP*, Liu YL*. Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM). J Biochem Mol Biol 2006; 39(4):406-411.

26.     Dong W#, Liu YL#,*, Peng J, Chen L, Zou T, Xiao H, Liu Z, Li W, Bu Y, Qi YP*. The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4. J Biol Chem 2006; 281(36):26029-26040.

27.     Liu YL#, Dong W#, Chen L, Zhang P, Qi YP*. Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. Biochem Biophys Res Commun 2004; 320(1):1-6.

28.      Liu YL#, Dong W#, Chen L, Xiang R, Xiao H, De G, Wang Z, Qi YP*. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem 2004; 279(36):37436.

奖励

2020年  教育部“奖励计划”新冠特岗教授

2010年  吴建国，叶林柏，朱应，刘映乐，邬开朗。湖北省自然科学奖一等奖。

2006年  刘映乐、董伟、齐义鹏。湖北省自然科学优秀学术论文特等奖。

2007年  董伟、刘映乐、齐义鹏。湖北省自然科学优秀学术论文一等奖。