教育经历

1997,8-2001,8   美国宾西法尼亚州立大学, 哲学博士

1991,9-1994,7   中国科学院动物学研究所, 理学硕士

1987,9-1991,7   南京大学, 理学学士

工作经历

2011.10-至今    中科院武汉病毒所分子病毒中心,研究员

2010,8-2011,9   美国克里夫兰临床医院, ResearchAssociate

2003,11-2010,8  美国凯斯西部保留地大学, ResearchAssociate

2003,6-2003,10  美国约翰霍普金斯大学, ResearchAssociate

2001,8-2003,5   美国凯斯西部保留地大学, ResearchAssociate

1994,7-1997,8   中国科学院上海昆虫学研究所, 技术员

学术兼职

2016.8-至今: Frontiers in Neurodegeneration, Frontiers in Neuroscience, Neurologyand Psychiatry (编委)。

2017.7-现在: 微生物和感染杂志 (编委)

研究内容

主要围绕病毒感染和肿瘤发生进行研究，尤其是朊病毒蛋白的表达与炎性反应的关联和促进肿瘤的发生发展机制；肿瘤微环境；肿瘤免疫治疗；肿瘤个体化治疗；朊病毒等神经退行疾病的致病机理。

主持项目

1.       科技部重大专项蛋白质重点研发计划（2018YFA0507201）高致病性病毒转录复制过程关键蛋白质机器的发现与组装模式，（项目骨干， 174万），2018-7-2022,12.

2.       中科院战略性先导项目A （项目批准号：XDA12010309），原发性肝癌抗肿瘤药物的生物标志物与药物靶标的发现与确证，项目执行期： 2017-2018（主持人， 100万）

3.       自然科学基金面上项目（项目批准号：31670170）：磷脂酰肌醇锚合成缺陷通过朊病毒蛋白（PrP）影响胰腺癌细胞转移的机制. 2017.1-2020.12（主持人，直接经费67万）。

4.       病毒学国家重点实验室“病毒学前沿科学重点研究项目：寨卡病毒感染致神经病变机制”，项目执行期2016.7-2018.12。（主持人， 100万）

5.       自然科学基金重大应急项目（81590764），埃博拉病毒感染的免疫病理研究。（参与人，40万）2015.0701-2017.12.31.已结题。

6.       湖北省科技厅(2015CFA087)，细胞型朊病毒蛋白或前朊病毒蛋白作为胰腺导管腺癌预后生物标记的研究，10万, 2015,1,1-2016,12,31。已结题。

7.       中科院武汉病毒所135培育项目, 人类烈性病毒感染的核糖核酸生物学研究，10万。已结题。

8.  科技部973项目(批准号:2013CB911102)：重要病毒转录复制蛋白复合体的结构功能研究（课题骨干， 120万）2013.1.1-2017.12.30。已结题。

9.  自然科学基金面上项目(批准号: 31270209)：突变型朊蛋白致病机理研究（主持人, 80万）2013.1.1-2016.12.30。已结题。

成果

1.      Run Shi, WeiminHu, Yan Zhang，Shanshan Gao, Andrew H. Smith, Jun Ye, Lili Cai, Linda M.Graham*, Chaoyang Li*, Ascorbate inducible N259 glycans on prolyl 4-hydroxylasesubunit α1 promote hydroxylation and secretion of Type I collagen, Cell MolLife Sciences, 2019, (第一通讯作者)( acceptedfor publication)

2.       Chang Kong; Hao Xie; Zhenxing Gao; Ming Shao; Huan Li; Run Shi; Lili Cai; Shanshan Gao; Taolei Sun; Chaoyang Li #,Binding between Prion Protein and Aβ Oligomers Contributes to Pathogenesis of Alzheimer’s Disease. Virologica Sinica, 2019, (通讯作者) (Accepted for publication).

3.      Zhenxing Gao*, Min Peng*, Liang Chen, Xiaowen Yang, Huan Li, Run Shi,Guiru Wu, Lili Cai, Qibin Song, Chaoyang Li^#, Prion Protein ProtectsCancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis, VirologicaSinica, 2019, (通讯作者) (Acceptedfor publication).

4.       Zhenxing Gao; Jing Shi; Lili Cai; Minhua Luo;BoonSeng Wong; Xiaoping Dong; Man-sun Sy; Chaoyang Li*, Prion dimer isheterogenous and is modulated by multiple negative and positive motifs. BBRC,2019, 509（2）： 570-6 (通讯作者)

5.       Huixia Zhang^1,2, Chao Zhang³,Hong Tang⁴, Shanshan Gao^1,2, Fang Sun^1,2, YuanYang⁵, Weiping Zhou⁵, Yu Hu⁶, Changshu Ke⁶,Yu Wu⁶, Zeyang Ding⁶, Lin Guo⁷, Rongjuan Pei¹,Xinwen Chen¹, Man-Sun Sy⁸, Bixiang Zhang⁶*, Chaoyang Li^1,9*CD2-associated Protein Contributes to Hepatitis C Virus Propagation andSteatosis by Disrupting Insulin Signaling, Hepatology, 2018, 68（5）： 1710-25. doi: 10.1002/hep.30073. (第一通讯作者)

6.       Zhang H X., Gao S S., Pei R J., Chen X W., Li C Y*., 2017, Hepatitis Cvirus-induced prion protein expression facilitates hepatitis C virusreplication. Virologica Sinica. 32(6):503-510. (通讯作者)

7.       Gui-Ru Wu, Tian-Chen Mu,Zhen-Xing Gao, Jun Wang, Man-Sun Sy, Chao-YangLi*. Prion protein isrequired for tumor necrosis factor alpha (TNFα)-triggered nuclear factor kappaB (NF-κB) signaling and cytokine production. 2017. JBC. 292: 18747-59. (通讯作者)

8.       Xiaowen Yang, Zhijun Chen, Lihua Zhang, GuiruWu, Run Shi, Zhenxing Gao, Chaoyang Li*.Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways. AdvExp Med Biol, Vol. 1018, Qiliang Cai et al. (Eds): Infectious Agents AssociatedCancers: Epidemiology and Molecular Biology. 2017, 1018:207-224. (通讯作者)

9.       Zhang H X, Shi R, Li C*, Howwill prion disease evolve (in Chinese)? Chin Sci Bull, 2017, 62: 16-24.(Invited Review) (通讯作者)

10.    Wang Y, Yu S, Huang D, Cui M, Hu H, Zhang L,Wang W, Parameswaran N, Jackson M, Osborne B, Bedogni B, Li C, Sy MS, Xin W, Zhou L. 2016. Cellular Prion Protein MediatesPancreatic Cancer Cell Survival and Invasion through Association with andEnhanced Signaling of Notch1. Am J Pathol. 2016 186(11):2945-2956.

11.    Zhenxing Gao,Huixia Zhang, Fei Hu, Liheng Yang, Xiaowen Yang, Ying Zhu, Man-Sun Sy, Chaoyang Li*. Glycan-deficient PrP stimulates VEGFR2signaling via glycosaminoglycan, Cellular Signalling, 2016, 28(6): 652-662. (通讯作者)

12.    Yang L, Gao Z,Hu L, Wu G, Yang X, Zhang L, Zhu Y, Wong BS, Xin W, Sy MS, Li C*. GPIAnchor Modification Machinery Deficiency is Responsible for the Formation ofPro-PrP in BxPC-3 and Increases Cancer Cell Motility. J Biol Chem. 2016,291(8):3905-17.  jbc.M115.705830 (通讯作者)

13.    Yang L, ZhangY, Hu L, Zhu Y, Sy MS, Li C*.2014  A panel of monoclonal antibodiesagainst the prion protein proves that there is no prion protein in humanpancreatic ductal epithelial cells. Virologica Sinica. 29(4):228-36 (通讯作者).

14.   Xiaowen Yang, Yan Zhang, Lihua Zhang, TianlinHe, Jie Zhang, and Chaoyang Li* 2014. Prion protein andcancers. Acta Biochim Biophys Sin. 46（6）： 431-40 (通讯作者).

15.   Wei Xin, Man-sun Sy, and Chaoyang Li., 2013.  CellularPrion Protein and Cancers. In Prions and Diseases. Edited by Wen-Quan Zou andPierluigi Gambetti.  Volume 1, Physiologyand Pathophysiology, 49-66.

16.   Sy, M., Altekruse S., Li, C., Lynch C., Goodman, M., Hernandes B., Zhou, L., Saber, M.,Hewitt, S., and Xin, W., 2012. Association of prion protein expression withpancreatic adenocarcinoma survival in the SEER residual tissue repository.Cancer Biomarkers.  10: 251-258.

17.   Li, C*., Yu, S*.,Nakamura, F., Wei, X., and Sy, M.S. 2010. Pro-prion binds FLNa facilitates itsinteraction with integrin 1 and contributes to melanomagenesis. Journal ofBiological Chemistry  285: 30328-39  (* co-first author)

18.   Li, C., Wei Xin, andSy, M.S.  2010.   Binding of filamin A to pro-prion: Is it bydesign or just an unfortunate blunder? Oncogene 29: 5329-45.

19.   Sy, MS.,Li, C., Yu, S., and X, Wei. 2010.  The fatal attractionbetween pro-prion and filamin A: Prion as a marker in human cancers. BiomarkersMed. 4(3): 453-464. 

20.   Li, C., Yu, S.,Nakamura, F., Yin, S., Xu, J., Patrolla, A.A., Singh, N., Tartakoff, T.,Abbott, D. W., X, Wei., and Sy, M.S. 2009. Binding of pro-prion to FLNadisrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.Journal of Clinical Investigation. 119: 2725-2736.

21.   Pham N, Yin S, Yu S, Wong P, Kang SC, Li C, Sy MS. 2008.  Normalcellular prion protein with a methionine at position 129 has a more exposedhelix 1 and is more prone to aggregate. Biochem Biophys Res Commun.368(4): 875-81.

22.   Yin S, Fan X, Yu S, Li C, Sy MS. 2008  Binding ofrecombinant but not endogenous prion protein to DNA causes DNA internalizationand expression in mammalian cells. Journal Biological Chemistry.283(37): 25446-54.

23.   Li, C*., Marrelli, M*., Yan, G. & Jacobs-Lorena, M.  2008   Fitness of Anopheles stephensi  transgenic mosquitoes expressing SM1 peptideunder control of vitellogenin promoter. Journal of Heredity. 99：275-282 (* co-first author)

24.   Yu S, Yin S, Pham N, Wong P, Kang SC, PetersenRB, Li C, Sy MS.  2008  Ligandbinding promotes prion protein aggregation--role of the octapeptide repeats.FEBS Journal. 275 (22): 5564-75.

25.   Chang B, Cheng X, Yin S, Pan T, Zhang H, Wong P,Kang SC, Xiao F, Yan H, Li C, WolfeLL, Miller MW, Wisniewski T, Greene MI, Sy MS. 2007 Test fordetection of disease-associated prion aggregate in the blood of infected butasymptomatic animals. Clin Vaccine Immunol. 14(1): 36-43

26.   Yin, S., Nancy Pham, Shuiliang Yu, Chaoyang Li, Poki Wong, Binggong Chang,Shin-Chung Kang, Emiliano Biasini, Po Tien, David A. Harris, and Man-Sun Sy. 2007.Human prion proteins with pathogenic mutations share common conformationalchanges resulting in enhanced binding to glycosaminoglycans. Proc. Nat. Acad.Sci. 104 (18): 7546-7551.

27.   Yu S,Yin S,Li C,Wong P,Chang B,Xiao F,Kang SC,Yan H,Xiao G,Tien P,Sy  M.S. 2007. Aggregationof prion protein with insertion mutations is proportional to the number ofinserts. Biochemical Journal. 403(2): 343-51.

28.   Goh AX1, LiC, Sy MS, Wong BS2007. Altered prion protein glycosylation in the agingmouse brain.  Journal of Neurochemistry.100 (3): 841-54.

29.   Li, C., Wong, P.,Pan, T., Robinson, J., Xiao, F., Yin, S., Chang, B., Kang, S., Ironside, J.,and Sy, M.S., 2007.  Normal cellularprion protein is a ligand of selectins: binding requires Lex but is inhibitedby sLex.  Biochemical Journal. 406 (2):333-41.

30.   Mauro T.Marrelli,Chaoyang Li,Jason L. Rasgon and Marcelo Jacobs-Lorena 2007. Increased fitness of transgenic mosquitoes thatfeed on Plasmodium-infected blood.  Proc.Nat. Acad. Sci. 104 (13): 5580-5583. (Co-first author, direct submission toPNAS).

31.   Yin, S., Yu, S., Li, C., Wong, P., Chang, B., Xiao, F., Kang, S.C.,Yan, H., Xiao, G., Grassi, J., Tien, P., and Sy, M.S. 2006. Prion proteins withinsertion mutations have altered N-terminal conformation, increasedligand-binding activity and are more susceptible to oxidative attack. Journalof Biological Chemistry 281: 10698-10705.

32.   Pan, T., Wong, P.,Chang, B., Li, C., Li, R., Kang S.C.,Robinson, J. D., Wisniewski, T., & Sy, M. S., 2005.  Biochemical fingerprints of prion infection:Accumulations of aberrant full-length and N-terminally truncated PrP speciesare common features in mouse prion disease. Journal of Virology   79, 934-943.

33.   Pan, T., Chang, B.,Wong, P., Li, C., Li, R., Kang, S.,Robinson, J. D., Thompsett, A., Tein, P., Yin, S., Barnard, G., McConnell, I., Brown, D., Wisniesdki, T., and Sy, M. S.,  2005   An aggregation-specific enzyme-linked immunosorbent assay: detection ofconformational differences between recombinant PrP protein dimmers and PrP^Scaggregates.  Journal of Virology    79: 12355-12364.

34.   Li, C., Cox-Foster, D., Gray, S. M. and Gildow, F.E.   2001. Vector specificity of Barley yellowdwarf virus (BYDV) transmission: Identification of potential cellular receptorsbinding BYDV-MAV in the aphid, Sitobion avenae.    Virology.  286, 125-133.