|
姓名 |
曹志贱 |
性别 |
男 |
职务 |
|
职称 |
教授 |
学历 |
博士研究生 |
通讯地址 |
武汉大学生命科学学院5114室 |
电话 |
027-68756746 |
邮编 |
430072 |
传真 |
027-68756746 |
电子邮件 |
zjcao@whu.edu.cn |
教育经历
1999.09-2004.06 武汉大学，生命科学学院微生物系，研究生，博士学位；
1994.09-1998.06 武汉大学，生命科学学院病毒学系，本科，学士学位。
工作经历
2015.02-至今 武汉大学病毒学国家重点实验室PI、生命科学学院教授；
2014.02-2015.01 美国梅哈里医学院生理学系，访问学者；
2006.12-2014.01 武汉大学生命科学学院，副教授；
2004.09-2006.011 武汉大学生命科学学院，讲师；
1998.07-1999.08 湖南省畜牧兽医研究所，实习研究员。
学术兼职
2014年受邀担任Infectious Disorders—DrugTargets杂志的Regional Editor。
2016年受邀担任Infectious Disorders—DrugTargets杂志的Co-Editor in Chief。
2013年被聘为中国毒理学会生物毒素毒理专业委员会委员第六届委员。
2017年被聘为中国毒理学会生物毒素毒理专业委员会委员第七届委员。
研究内容
致力于病毒感染的细胞应激生物学研究及其相关抗病毒多肽药物研究。以作用于离子通道、膜受体或者酶的动物毒素多肽为分子探针，利用乙型肝炎病毒（HCV）、寨卡病毒（ZIKV）、登革热病毒（DNEV）等作为模式病毒，深入研究病毒和宿主相互作用及感染致病机制，发展有效的抗病毒策略。
主持项目
1. 国家自然科学基金面上项目（基金号：31872239）
课题名称：蝎毒素多肽探针Sm286在宿主抗病毒蛋白钾通道Kv1.3发现中的作用与机制研究
执行年限：2019-2022
承担角色：主持人
资助金额：620,000人民币
2. 国家自然科学基金面上项目（基金号：31572289）
课题名称：钾离子通道介导蝎毒素多肽Hp98抑制HBV复制研究.
执行年限：2016-2019
承担角色：主持人
资助金额：600,000人民币
3. 国家自然科学优秀青年基金项目（基金号：31422049）
课题名称：蝎毒素遗传资源的保护、认识与利用研究
执行年限：2015-2017
承担角色：主持人
资助金额：1,000,000人民币
4. 国家“十一五”重大新药专项项目 (基金号:2009ZX09103-612)
课题名称: 抗耐甲氧西林金黄色葡萄球菌(MRSA) 耐药病原菌的新型天然多肽药物研制
执行年限：2010-2013
承担角色: 主持人
资助金额: 1,500,000人民币
5. 国家自然科学基金面上项目 (基金号:30971500)
课题名称: 重组氯毒素BmKCT靶向抗神经胶质瘤的分子机理研究
执行年限：2010-2012
承担角色: 主持人
资助金额: 300,000人民币
成果
1. Li F,Lang Y, Ji Z, Xia Z, Han Y, Cheng Y, Liu G, Sun F, Zhao Y, Gao M, Chen Z, Wu Y,Li W, Cao Z*. A scorpionvenom peptide Ev37 restricts viral late entry by alkalizing acidic organelles. JBiol Chem. 2019 Jan 4;294(1):182-194.
2. Zeng Z,Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y*, Cao Z*. Histidine-richmodification of a scorpion-derived peptide improves bioavailability andinhibitory activity against HSV-1. Theranostics. 2018 Jan1;8(1):199-211.
3. Liu G,Yang F, Li F, Li Z, Lang Y, Shen B, Wu Y, Li W, Harrison PL, Strong PN, Xie Y,Miller K*, Cao Z*.Therapeutic potential of a scorpion venom-derived antimicrobial peptide and itshomologs against antibiotic-resistant gram-positive bacteria. FrontMicrobiol. 2018 May 29;9:1159.
4. Ji Z,Li F, Xia Z, Guo X, Gao M, Sun F, Cheng Y, Wu Y, Li W, Ali SA, Cao Z*. A scorpion venom peptideSmp76 inhibits viral replication by regulating type-I interferon response. VirolSin. 2018 Dec;33(6):545-556.
5. Shen B,Song J, Zhao Y, Zhang Y, Liu G, Li X, Guo X, Li W, Cao Z*, Wu Y*. Triintsin, a human pathogenic fungus-deriveddefensin with broad-spectrum antimicrobial activity. Peptides. 2018Sep;107:61-67.
6. Lang Y,Pi X, Di Z, Zhang Q, Wang H, Shen B, Li F, Liu G, Yu Y, Li X, Wu Y, Li W, Cao Z*. Molecularcharacterization and expression analysis of CSαβ defensin genes from thescorpion Mesobuthus martensii. Biosci Rep. 2017 Dec 15;37(6).
7. Zeng Z,Han S, Hong W, Lang Y, Li F, Liu Y, Li Z, Wu Y, Li W, Zhang X*, Cao Z*. A Tat-conjugated Peptide Nucleic AcidTat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo byTargeting LTR Direct Repeats of HBV RNA. Mol Ther Nucleic Acids. 2016 Mar15;5:e295.
8. Li Z,Liu G, Meng L, Yu W, Xu X, Li W, Wu Y*, CaoZ*. K1K8: an Hp1404-derived antibacterial peptide. ApplMicrobiol Biotechnol. 2016 Jun;100(11):5069-5077.
9. Meng L,Xie Z, Zhang Q, Li Y, Yang F, Chen Z, Li W, Cao Z*, Wu Y*. Scorpion potassium channel-blockingdefensin highlights a functional link with neurotoxin. J Biol Chem. 2016,291(13):7097-7106.
10. ZhangC, Xie Z, Li X, Chen J, Feng J, Lang Y, Yang W, Li W, Chen Z, Yao J, Cao Z*, Wu Y*. Molecular basis for the toxininsensitivity of scorpion voltage-gated potassium channel MmKv1. BiochemJ. 2016, 473(9):1257-1266.
11. Zeng Z,Zhang Q, Hong W, Xie Y, Liu Y, Li W, Wu Y, CaoZ*. A scorpion defensin BmKDfsin4 inhibits hepatitis Bvirus replication in vitro. Toxins (Basel). 2016 Apr 27;8(5).
12. Hong W,Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, CaoZ*. A p7 ion channel-derived peptide inhibits hepatitis Cvirus infection in vitro. J Biol Chem. 2015,290(38):23254-23263.
13. Di Z,Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X*, Li W*, Cao Z*. Genome-wide analysis of homeobox genesfrom Mesobuthus martensii reveals Hox gene duplication in scorpions. InsectBiochem Mol Biol. 2015, 61:25-33.
14. Song Y,Gong K, Yan H, Hong W, Wang L, Wu Y, Li W*, Li W*, Cao Z*. Sj7170, a unique dual-functional peptide with aspecific α-chymotrypsin inhibitory activity and apotent tumor activating effect from scorpion venom. J Biol Chem. 2014,289(17):11667-11680.
15. Hong W,Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z*. Inhibitory activity and mechanism of two scorpionvenom peptides against herpes simplex virus type 1. Antiviral Res. 2014, 102:1-10.
16. Li Z, Xu X, Meng L, Zhang Q, Cao L, Li W, Wu Y, Cao Z*. Hp1404,a new antimicrobial peptide from the scorpion Heterometrus petersii. PLoSOne. 2014 May 14;9(5):e97539.
17. Cao Z#, Di Z#, Wu Y, Li W. Overview ofscorpion species from China and their toxins. Toxins (Basel).2014 Feb 26;6(3):796-815.
18. Cao Z#, Yu Y#, Wu Y#, Hao P#,Di Z#, He Y#, Chen Z, Yang W, Shen Z, He X, Sheng J, XuX, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H,Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X,Zhao G, Li X, Li Y, Li W. The genome of Mesobuthus martensii reveals a uniqueadaptation model of arthropods. Nat Commun. 2013, 4:2602.
19. Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z*. Design of histidine-rich peptides with enhancedbioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 2013, 34(13):3511-3522.
20. He Y, Zhao R, Di Z, Li Z, Xu X, Hong W, Wu Y, Zhao H, Li W, Cao Z*. Molecular diversity of Chaerilidae venom peptidesreveals the dynamic evolution of scorpion venom components from Buthidae tonon-Buthidae. J Proteomics. 2013, 89:1-14.
21. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W*, Cao Z*. Mucroporin-M1inhibits Hepatitis B virus replication by activating the mitogen-activatedprotein kinase (MAPK) Pathway and down-regulating HNF4α in vitro and in vivo. JBiol Chem. 2012, 287(36):30181-30190.
22. Ma Y,He Y, Zhao R, Wu Y, Li W*, Cao Z*.Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomicanalysis: Implication for proteome evolution of scorpion venom arsenal. JProteomics. 2012, 75(5):1563-1576.
23. Chen Y,Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J,Sun Y, Cao Y, Li Y, Li W, Guo D, CaoZ*, Yan H*. Anti-HIV-1 activity of a new scorpion venom peptidederivative Kn2-7. PLoS One. 2012, 7(4):e34947.
24. Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z*, Li W*. Antibacterial activity and mechanism of a scorpion venom Peptidederivative in vitro and in vivo. PLoS One. 2012, 7(7):e40135.
25. Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W*, Cao Z*. Ctriporin,a new anti-methicillin-resistant Staphylococcus aureus peptide from the venomof the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother. 2011, 55(11):5220-5229.
26. Zhao R, Dai H, Qiu S, Li T, He Y, Ma Y, Chen Z, Wu Y, Li W*, Cao Z*. SdPI, the first functionally characterized Kunitz-typetrypsin inhibitor from scorpion venom. PLoS One. 2011, 6(11):e27548.
27. Yu XF,Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu Y, Cao Z*, Li W*. Neurotoxin-conjugated upconversion nanoprobes for directvisualization of tumors under near-infrared irradiation. Biomaterials. 2010, 31(33):8724-8731.
28. Fan S, Sun Z, Jiang D, Dai C, Ma Y, Zhao Z, Liu H, Wu Y, Cao Z*, Li W*. BmKCT toxininhibits glioma proliferation and tumor metastasis. Cancer Lett. 2010, 291(2):158-166.
29. Zhao R,Ma Y, He Y, Di Z, Wu Y, Cao Z*,Li W*. Comparative venom gland transcriptome analysis of the scorpion Lychasmucronatus reveals intraspecific toxic gene diversity and new venomouscomponents. BMC Genomics. 2010, 11:452.
30. Ma Y,Zhao Y, Zhao R, Zhang W, He Y, Wu Y, CaoZ*, Guo L*, Li W*. Molecular diversity of toxic components from thescorpion Heterometrus petersii venom revealed by proteomic and transcriptomeanalysis. Proteomics. 2010, 10(13):2471-2485.
31. Yuan W, Cao L, Ma Y, Mao P, Wang W, Zhao R, Wu Y, Cao Z*, Li W*. Cloningand functional characterization of a new antimicrobial peptide gene StCT1 fromthe venom of the scorpion Scorpiops tibetanus. Peptides. 2010, 31(1):22-26.
32. Zhao Z, Ma Y, Dai C, Zhao R, Li S, Wu Y, Cao Z*, Li W*. Imcroporin, a new cationic antimicrobial peptide from the venom of thescorpion Isometrus maculates. Antimicrob Agents Chemother. 2009, 83:3472-3477.
33. Ma Y, Zhao R, He Y, Li S, Liu J, Wu Y, CaoZ*, Li W*. Transcriptomeanalysis of the venom gland of the scorpion Scorpiops jendeki: implication forthe evolution of the scorpion venom arsenal. BMC Genomics. 2009, 10:290.
34. Ma Y, Zhao R, Li S, Fan S, Wu Y, Liu H, Cao Z*, Li W*. Characterization of LmTxLP11 and LmVP1.1 transcripts and genomicorganizations: Alternative splicing contributing to the diversity of scorpionvenom peptides. Toxicon. 2009, 53:129-134.
35. Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z*, Li W*. Mucroporin, the first cationic host defence peptide from the venom ofLychas mucronatus. Antimicrob Agents Chemother. 2008, 52(11):3967-3972.
36. Wu W,Yin S, Ma Y, Wu YL, Zhao R, Gan G, Ding J, CaoZ*, Li W*. Molecular cloning and electrophysiological studies on thefirst K(+) channel toxin (LmKTx8) derived from scorpion Lychas mucronatus. Peptides.2007, 28: 2306-2312.
37. Cao Z#, Luo F, Wu Y, Mao X, LiW*. Genetic Mechanisms ofScorpion Venom Peptides Diversification. Toxicon. 2006, 47: 348-355.
38. Cao Z#, Mao X, Xu X, Sheng J, Dai C, Wu Y, Luo F,Sha Y, Jiang D, Li W*. Adaptive evolution after gene duplication in α-KTx14subfamily from Buthus martensii Karsch. IUBMB life. 2005, 57: 513-521.
39. Cao Z#, Xiao F, Peng F, Jiang D, Mao X, Liu H, LiW*, Hu D, Wang T. Expression, purification and functional characterization of arecombinant scorpion venom peptide BmTXKβ. Peptides. 2003, 24: 187-192.
40. Cao Z#, Zhu S, Li W*, Jiang D,He X, Liu H.. Genomicorganization of BmTXKβ and BmTXKS2, two scorpion venom peptides from Buthusmartensii Karsch. IUBMB life. 2001, 51:305-308.
奖励
2016年获中国毒理学会优秀青年科技奖。
2014年获国家自然科学优秀青年基金项目。
2015年获湖北省杰出青年基金项目。
2006年获武汉市青年科技晨光计划。
2005年获湖北省自然科学一等奖（排名第五）。
