教育经历

2002.06                     武汉大学生命科学学院，博士学位（在职）

1985.09-1988.06     武汉大学生物系，研究生，硕士学位；

1981.09-1985.06     武汉大学生物系，本科，学士学位；

工作经历

1988.07-至今        武汉大学生命科学学院，先后任助教、讲师、副教授、教授、博士生导师；

学术兼职

《微生物学通报》副主编(Associate Editor)             

《生物资源》编委会副主任 (Associate Director of the Editorial Board)

中国微生物学会常务理事

中国微生物学会教学工作委员会主任

中国微生物学会基础微生物学专业委员会委员

中国微生物学会分子微生物学与生物工程专业委员会委员

中国遗传学会微生物遗传学专业委员会副主任、委员

美国微生物学会会员

湖北省微生物学会常务理事

湖北省遗传学会常务理事

研究内容（限200字）

主要以分子遗传学手段，对下列细菌和古菌开展研究：揭示能共存于同一嗜盐古菌细胞的二个有包膜的古菌溶原病毒的基本生物学特性，以及病毒之间、病毒与宿主间的相互关系，拓展对古菌病毒多样性的认识；以枯草芽胞杆菌的为材料，对细菌细胞间水平基因转移过程开展研究，以期揭示一种新的细菌间遗传交换机制；揭示气单胞菌黑色素形成的分子机理，为进一步探究细菌黑色素的生物学意义特别是与致病性之间的相关性奠定理论和实验基础。

主持项目（限10项）

1.国家自然科学基金面上项目

课题名称：气单胞菌属细菌的黑色素形成分子机制及相关生物学功能的进一步研究（项目编号：31770052）

执行年限：2018-2021

承担角色：项目负责人

资助金额：600,000人民币

2.国家自然科学基金面上项目

课题名称：共存于极端嗜盐古菌Natrinema sp.J7-1中的二个溶原病毒及病毒－宿主间相互作用的研究（项目编号：31570174）

执行年限：2016-2019

承担角色：项目负责人

资助金额：764,000人民币

3.国家自然科学基金面上项目

课题名称：一种新的细菌间基因水平转移途径? - - 枯草芽孢杆菌细胞间遗传重组过程的基本特性研究及机理揭示（项目编号：31270145）

执行年限：2013-2016

承担角色：项目负责人

资助金额：764,000人民币

4. 973项目

课题名称：若干重大地质环境突变的地球生物学过程（项目编号：2011CB808802）

执行年限：2011-2015

承担角色：子项目负责人

资助金额：740,000人民币

5.国家自然科学基金面上项目

课题名称：中间气单胞菌WS菌株中与黑色素形成相关的独特酪氨酸酶基因的功能分析（项目编号：31070077）

执行年限：2011-2013

承担角色：项目负责人

资助金额：400,000人民币

6.国家自然科学基金面上项目

课题名称：枯草芽孢杆菌的DNA胞外释放现象与缺陷性原噬菌体PBSX的相关性研究（项目编号：30770042）

执行年限：2008-2010

承担角色：项目负责人

资助金额：300,000人民币

7.国家自然科学基金面上项目

课题名称：枯草芽孢杆菌的特定DNA片段胞外分泌及其转化活性的研究（项目编号：30670041）

执行年限：2007.1-2007.12

承担角色：项目负责人

资助金额：80,000人民币

8.国家自然科学基金面上项目

课题名称：在固相基质表面进行的细菌自然遗传转化研究（项目编号：30470032）

执行年限：2004-2007

承担角色：项目负责人

资助金额：200,000人民币

9.国家自然科学基金面上项目

课题名称：枯草芽孢杆菌主动分泌DNA的研究（项目编号：30070010）

执行年限：2001-2003

承担角色：项目负责人

资助金额：140,000人民币

成果（限40篇）

1、Qinggong Guo, Beibei Chen, Yishuai Tu,Shishen Du * and Xiangdong Chen*（2019）Prophage LambdaSo uses replication interference to suppressreproduction of coexisting temperate phage MuSo2 in Shewanella oneidensis MR-1.EnvironMicrobiol. 2019 Mar 18. doi: 10.1111/1462-2920.14592. [Epubahead of print]

2、Yunqian Qiao,Jiao Wang, He Wang, Baozhong Chai, Chufeng Rao, Xiangdong Chen*, Shishen Du*(2019),^,4-hydroxyphenylpyruvatedioxygenase thermolability is responsible for temperature-dependentmelanogenesis in Aeromonas salmonicida subsp. salmonicida, Appl.Environ, Microbiol. 85(1), e01926-18

3、Xiaoming Zhang, Tingting Jin, Liping Deng,Chao Wang, Yuhua Zhang, Xiangdong Chen* (2018), Stress-Induced, HighlyEfficient, Donor Cell-Dependent Cell-toCell Natural Transformation in Bacillussubtilis,J Bacteriol  200(17): e00267-18.

4、Ruili Zhao, RuiZhao, Yishuai Tu, Xiaoming Zhang, Liping Deng, Xiangdong Chen*  (2018) A novel α-galactosidase from thethermophilic probiotic Bacillus coagulans with remarkable protease-resistanceand high hydrolytic activity. PLoS ONE 13(5): 1-16,e0197067

5、Jiao Wang, Yingchun Liu, Ying Liu, KaixinDu, Shuqi Xu, Yuchen Wang, Mart Krupovic, XiangdongChen* (2018) A novel familyof tyrosine integrases encoded by the temperate pleolipovirus SNJ2, NucleicAcids Res,  46(5):2521–2536, https://doi.org/10.1093/nar/gky005 

6、Yuchen Wang,  Beibei Chen, Mengzhuo Cao,  Linshan Sima,  DavidPrangishvili,  XiangdongChen*, MartKrupovic* (2018)  Rolling-circle replication initiation proteinof haloarchaeal sphaerolipovirus SNJ1 is homologous to bacterial transposasesof the IS91 family insertion sequences, J Gen., Virol, 99:416-421, doi: 10.1099/jgv.0.001009 

7、YuchenWang, Beibei Chen, Linshan Sima, Mengzhuo Cao, and Xiangdong Chen*(2017)  Construction of Expression Shuttle Vectorsfor the Haloarchaeon Natrinema sp. J7Based on Its Chromosomal Origins of Replication，Archaea，Volume2017, Article ID 4237079, 11 pages

8、Baozhong Chai, Yunqian Qiao, He Wang,Xiaoming Zhang, Jiao Wang,Choushi Wang, Ping Zhou and Xiangdong Chen*(2017) Identification of YfiH and theCatalase CatA As Polyphenol Oxidases of Aeromonas media and CatA as aRegulator of Pigmentation by Its Peroxyl Radical Scavenging Capacity，Fron., Microbiol. 8:1939. doi:10.3389/fmicb.2017.01939，12pages

9、Yuchen Wang, LinshanSima, Jie Lv, Suiyuan Huang, Ying Liu, Jiao Wang, Mart Krupovic, Xiangdong Chen*，(2016),Identification, characterization and application of the replicon region of thehalophilic temperate sphaerolipovirus SNJ1. J Bacteriol.,198(4):1952-1964

10、Salla T. Jaakkola,Friedhelm Pfeiffer,Janne J. Ravantti, Qinggong Guo,Ying Liu, Xiangdong Chen, Hongling Ma, ChunheYang,Hanna M. Oksanen , Dennis H.Bamford*，(2016), The complete genome of a viablearchaeum isolated from 123-million-year-old rock salt, Environ. Microbiol.18(2), 565–579

11. 晋婷婷，付正伟，沈萍，陈向东*，（2016），枯草芽孢杆菌携带PBSX类缺陷性原噬菌体的普遍性调查，微生物学通报, 43(6): 1244-1252

12. 张春芝、陈贝贝、雷明瑄、郭庆功、陈向东*，一株奥奈达希瓦氏菌烈性噬菌体的分离、纯化及鉴定，微生物学通报，Sep.20, 2016, 43(9): 1953−1959

13. Ying Liu, Jiao Wang, Yang Liu, YuchenWang, Ziqian Zhang, Hanna M. Oksanen, Dennis H. Bamford and Xiangdong Chen* (2015) Identification and characterization of SNJ2, the first temperatepleolipovirus integrating into the genome of the SNJ1-lysogenic archaealstrain. Mol. Microbiol. 98(6), 1002–1020

14．Jie Lv, Shuai Wang, Yuchen Wang,Yuping Huang, Xiangdong Chen*,(2015), Isolation and Molecular Identification of AuxotrophicMutants to Develop a Genetic Manipulation System for the Haloarchaeon Natrinema sp. J7-2. Archaea Volume 2015,Article ID 483194, 16 pages

15. Yunjun Mei*, Congcong He,Yongchi Huang, Ying Liu, Ziqian Zhang, XiangdongChen*, Ping Shen, (2015), Salinity Regulation of the Interaction ofHalovirus SNJ1 with Its Host and Alteration of the Halovirus ReplicationStrategy to Adapt to the Variable Ecosystem. PLoS ONE  10(4): e0123874. doi:10.1371/journal.pone.0123874. eCollection 2015

16．He Wang, Yunqian Qiao, Baozhong Chai,Chenxi Qiu, Xiangdong Chen* ,(2015),Identification and Molecular Characterization of the Homogentisate PathwayResponsible for Pyomelanin Production, the Major Melanin Constituents in Aeromonas media WS. PLoS ONE  10(3): e0120923.doi:10.1371/journal.pone.0120923

17. Tingting Jin,  Xiaoming Zhang,  Yang Zhang, Zhongsheng Hu, Zhengwei Fu,  Junpeng Fan, Ming Wu,  Yi Wang, Ping Shen, Xiangdong Chen* ,(2014), Biological and genomicanalysis of a PBSX-like defective phage induced from Bacillus pumilus AB94180. Arch Virol. 159: 739–752

18. Salla T. Jaakkola, KarolinZerulla, Qinggong Guo, Ying Liu, Hongling Ma, Chunhe Yang, Dennis H. Bamford, Xiangdong Chen* Jörg Soppa*, Hanna M. Oksanen* ,(2014), Halophilic Archaea Cultivatedfrom Surface Sterilized Middle-Late Eocene Rock Salt Are Polyploid，PLOS ONE 9(10):e110533: 1-9

19. Yi Wang, Zhenmin Chen, RuiliZhao, Tingting Jin, Xiaoming Zhang, XiangdongChen^*,(2014), Deleting multiple lytic genes enhances biomassyield and production of recombinant proteins by Bacillus subtilis, Microb Cell Fact.  13:129: 1-11

20．柴保中, 王禾, 彭珍荣, 沈萍, 陈向东*,(2014), 细菌黑色素的合成途径及生物功能研究进展，微生物学通报,41(2): 334-343

21. Jie Lv, Shuai Wang, Chi Zeng,Yuping Huang, Xiangdong Chen*,(2013),Construction of a shuttle expression vector with a promoter functioning in bothhalophilic Archaea and Bacteria. FEMS Microbiol. Lett. 349,9-15

22. Baozhong Chai, He Wang, Xiangdong Chen*, (2012), Draft GenomeSequence of High-Melanin-Yielding Aeromonasmedia Strain WS. J. Bacteriol. 194 (23): 6693–6694

23. Ziqian Zhang, Ying Liu, Shuai Wang, DiYang, Yichen Cheng, Jiani Hu, Jin Chen, Yunjun Mei, Ping Shen, Dennis H.Bamford, Xiangdong Chen*, (2012), Temperate membrane-containinghalophilic archaeal virus SNJ1 has a circular dsDNA genome identical to that ofplasmid pHH205. Virology. 434: 233–241

24. Hongbo Wei, Shexiao Zou, Xiaolin Yang,Daiqin Yang, Xiangdong Chen*,(2012), Development of multiplexreal-time quantitative PCR for simultaneous detection of Chlamydia trachomatis andUreaplasma parvum，Clin.Biochem.45(9):663-667.

25. Jing Geng, Peng Yuan, Chun Shao,Sheng-Bing Yu, Bo Zhou, Ping Zhou, Xiang-DongChen*, Bacterial melanininteracts with double-stranded DNA with high affinity and may inhibits cellmetabolism in vivo, Arch. Microbiol., 2010,192(5):321-329

26. Zhenmin Chen, Qing Li, Huamei Liu, NaYu, Tianjian Xie, Mingyuan Yang, Ping Shen, Xiangdong Chen*,(2010), Greater enhancement of Bacillussubtilis spore yields in submerged cultures by optimization of mediumcomposition through statistical experimental designs. Appl. Microbiol,Biotech. 85:1353–1360

27. Chi Zeng, Yingzi Zhao, Changzheng Cui,Hao Zhang, Jianyu Zhu, Xiaofeng Tang, Ping Shen, Yuping Huang *, XixngaodngChen*,(2009), Characterization of the Haloarculahispanica amyH gene promoter, an archaeal promoter that confers promoteractivity in Escherichia coli，Gene  442(1-2):1-7.

28. Xia. Wan, Baozhong. Chai, Yi. Liao,Ying. Su, Tao. Ye, Ping. Shen, Xiangdong.Chen*,(2009), Molecular and biochemical characterization of a distincttyrosinase involved in melanin production from Aeromonas media. Appl.Microbiol, Biotech. 82(2):261-9

29. Yunjun. Mei, Dong. Chen, Dongchang.Sun, Yang. Yang, Yuping. Huang, Ping. Shen, and Xiangdong. Chen*,(2008), An Easier Method for Locating ReplicationOrigins Based on Real-Time Polymerase Chain Reaction. Curr Microbiol.,56,633-8

30. Jing. Geng, Wei. Tang, Xia. Wan, Qing.Zhou, Xiaojun. Wang, Ping. Shen, Tiechi. Lei*, Xiangdong. Chen*,（2008）, Photoprotection of bacterial-derivedmelanin against UVA induced cell death and its potential application as anactive sunscreen. J Euro Acade Dermatol Venereol.,22,852-858.

31. Jing. Geng, Shunbing. Yu, Xia. Wan,Xiaojuan. Wang, Ping. Shen, Ping. Zhou, Xiangdong.Chen* ,(2008), Protective action of bacterial melanin against DNA damage infull UV spectrums by a sensitive plasmid-based noncellular system. J Bioch Bioph Meth.,70,1151-1155..

32. Xia. Wan, Huihui. Liu, Yi. Liao, Yi.Su, Jing. Geng, Mingyuan. Yang, Xiangdong.Chen*, Ping Shen, (2007),. Isolation of a novel strain of Aeromonas media producing high levels ofDOPA-melanin and assessment of the photoprotective role of the melanin inbioinsecticide applications. J Appl Microbiol.,103,2533–41.

33. Yunjun. Mei, Jing. Chen, Dongchang.Sun, Dong. Chen, Yang. Yang, Ping. Shen, Xiangdong.Chen*,(2007), Induction and primary characterization of a novel halophageSNJ1 from lysogenic Natrinema sp. F5with mitomycin C. Can. J.Microbiol.,53,1106-1110.

1.         34. Xiaojuan. Wang, Meiju. Li, Qing. Yan, Xiangdong. Chen*, Jing. Geng, Zhixiong. Xie, Ping. Shen, (2007),Across genus plasmid transformation between Bacillus subtilis and Escherichiacoli and the effect of Escherichia colion the transforming ability of free plasmid. Curr Microbiol.,54,450-6

奖励

2005 宝钢优秀教师特等奖

2011 湖北省教学名师