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教育简历:

 

04/1992 - 10/1993法国马赛大学 细胞生物学 博士

09/1985 - 09/1988中国疾病控制中心(中国预防医学科学院) 硕士

09/1978 - 08/1983山东大学(山东医学院)医学士

 

工作简历

 

12/2009 -  至今     国家特聘专家- 千人计划学者

01/2017 -  至今武汉大学健康学院教授/院长

09/2017 -  至今美国德克萨斯大学病理系客座教授

Adjunct Professor,Departments of Pathology and Microbiology and Immunology,University of Texas Medical Branch,Galveston, Texas

10/2009 – 09/2017美国德克萨斯大学 终身教授

01/2012 – 12/2016山东大学公共卫生学院教授

01/2012 – 11/2015山东大学公共卫生学院院长

07/2009 – 12/2011中国疾病控制中心传染病预防控制所 教授、立克次体室主任

10/2003 – 09/2009美国德克萨斯大学 副教授Associate Professor with tenure

10/1997 – 09/2003美国德克萨斯大学 助理教授Assistant Professor (Tenure Track)

10/1996 – 09/1997美国德克萨斯大学 讲师Instructor

12/1993 – 09/1996 美国德克萨斯大学 博士后Post-doctoral Fellow

09/1989 – 03/1992中国疾病控制中心 助理研究员

04/1987 – 08/1989美国德克萨斯大学 访问学者Visiting Scientist

04/1987 – 08/1887美国德北卡罗来纳大学 访问学者University of North Carolina,Chapel Hill, North Carolina

10/1983– 03/1987中国疾病控制中心 实习研究员

 

学术兼职

Editorial Board

Virologica Sinica2017 -至今

Infectious Diseases and Translational Medicine2016 -至今

BioScience Trends2013 -至今

PloS One2012 - 至今 

Journal of Bacteriology & Parasitology2011 - 至今

ISRN Microbiology2011 – 2014

 

研究内容

 

致力于新发传染病的流行病学和致病机理研究,包括新发传染病的传播途径、媒介与宿主和新发传染病的诊断方法、病毒和细菌逃逸宿主的免疫机制。在世界上首先发现了一种高致病性的病毒SFTSV,这种病毒由媒介蜱虫叮咬传播, 亦可人传人,该病毒的病死率高达30-50%。 该病毒在中国,韩国和日本广泛分布, 在美国有类似病毒。

 

主持项目

 

在国内外主持过10多项国家自然科学基金课题和美国国立卫生研究院课题,代表性的课题

 

1.2016.01-2019.12:主持国家自然科学基金面上项目:SFTSV对宿主细胞自噬的影响及其分子机制的研究。课题号:31570167,金额:¥67万

2.2015/01-2017/12:主持山东省科技发展计划课题:媒介传播疾病快速特异诊断方法的建立。 课题号:2014GSF121004, 金额:¥12万

3.2006/07–2011/09  主持美国国立卫生研究院U01课题:Vaccine for epidemic typhus, 课题号: U01AI71283, 金额:$2,479,899

4.2009/09 – 2011/08 主持美国西部卓越中心课题: Rickettsial Attenuation by Targeted Gene Knockout,金额:$624,997

5.2001 /12– 2006/01  主持美国国立卫生研究院R01课题: Molecular basis of persistent Ehrlichia infection,课题号:A145871金额:$1,073,805

 

 

成果

迄今发表论文130多篇,其中SCI 117篇,一区杂志文章16 篇,包括New England Journal of Medicine( impact factor, IP 72.406), The Journal of the American Medical Association (IP 44.405) 2 篇,Lancet Infectious Diseases (IP 19.864),Emerging Infectious Diseases (IP 8.222)。发表在新英格兰医学杂志的文章(Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China), 被世界新闻界包括报纸和电视传媒广泛报道,被世界著名杂志Science和Cell专题报道, 为高被引论文,Web of Science引用次数达500 多次,Google scholar 引用次数达 900多次。

 

英文文章

 

1. Han H-J, Wen H-L, Liu J-W, Qin X-R, Zhao M, Wang L-J, Luo LM, Zhou CM, Zhu YL, Qi R, Li WQ, Yu H, and Yu XJ. Pathogenic Leptospira species in insectivorous bats, China, 2015. Emerg Infect Dis. 2018. https://doi.org/10.3201/eid2406.171585

2. Sun Y, Liu MM, Lei XY, Yu XJ. SFTS phlebovirus promotes LC3-II accumulation and nonstructural protein of SFTS phlebovirus co-localizes with autophagy proteins. Sci Rep. 2018;8(1):5287. doi: 10.1038/s41598-018-23610-0. PubMed PMID: 29588492; PubMed Central PMCID: PMC5869591.

 

3. Qin XR, Han FJ, Luo LM, Zhao FM, Han HJ, Zhang ZT, Liu JW, Xue ZF, Liu MM, MaDQ, Huang YT, Yue Sun, Sun XF, Li WQ, Zhao L, Hao Yu, Yu XJ. Anaplasma species detected in Haemaphysalis longicornis tick from China. Ticks Tick Borne Dis. 2018. pii: S1877-959X(17)30438-7. doi: 10.1016/j.ttbdis.2018.03.014. PubMed PMID: 29567147.

 

4. Wang GS, Du Y, Wu JQ, Tian FL, Yu XJ, Wang JB. Vaccine resistant pseudorabies virus causes mink infection in China. BMC Vet Res. 2018;14(1):20. doi: 10.1186/s12917-018-1334-2. PubMed PMID: 29351775; PubMed Central PMCID: PMC5775606.

 

5. Li J, Gao F, Hao SB, Cheng D, Zhang WQ, Lin B, Zhao L, Yu XJ, Wang ZY, Wen HL. Contribution of 3CD Region to the Virulence of Enterovirus 71. Biomed Environ Sci. 2017;30(10):767-771. doi: 10.3967/bes2017.103. PubMed PMID: 29122098.

 

6. Latif A, Liu BY, Chen Z, Sun Y, Shi YL, Zong J, Li JJ, Ren CP, Zhang XC, Liu XN, Yu XJ, Liu Y. Orientia tsutsugamushi infection in rodents in Anhui Province of China. Infect Genet Evol. 2017;56:14-18. doi:10.1016/j.meegid.2017.10.014. PubMed PMID: 29037778.

 

7. Wang GS, Wang JB, Tian FL, Zhang HJ, Yin FF, Xu C, Xu D, Huang YT, Yu XJ. Severe Fever with Thrombocytopenia Syndrome Virus Infection in Minks in China. Vector Borne Zoonotic Dis. 2017;17(8):596-598. doi: 10.1089/vbz.2017.2115. PubMed PMID: 28654374.

 

8. Huang Y, Zhao L, Zhang Z, Liu M, Xue Z, Ma D, Sun X, Sun Y, Zhou C, Qin X, Zhu Y, Li W, Yu H, Yu XJ. Detection of a Novel Rickettsia From Leptotrombidium scutellare Mites (Acari: Trombiculidae) From Shandong of China. J Med Entomol. 2017;54(3):544-549. doi: 10.1093/jme/tjw234. PubMed PMID: 28399204.

 

9. Sun Y, Liu MM, Luo LM, Zhao L, Wen HL, Zhang ZT, Liu JW, Xue ZF, Ma DQ, Ding SJ, Lei XY, Yu XJ. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Hedgehog from China. Vector Borne Zoonotic Dis. 2017;17(5):347-350. doi: 10.1089/vbz.2016.2019. PubMed PMID: 28323557.

 

10. Sun XF, Zhao L, Zhang ZT, Liu MM, Xue ZF, Wen HL, Ma DQ, Huang YT, Sun Y, Zhou CM, Luo LM, Liu JW, Li WQ, Yu H, Yu XJ. Detection of Imjin Virus and Seoul Virus in Crocidurine Shrews in Shandong Province, China. Vector Borne Zoonotic Dis. 2017;17(6):425-431. doi: 10.1089/vbz.2016.2056.. PubMed PMID: 28287930.

 

11. Liu MM, Lei XY, Yu H, Zhang JZ, Yu XJ. Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome. Virol J. 2017 Jan 13;14(1):6. doi: 10.1186/s12985-016-0677-1. PubMed PMID: 28086978; PubMed Central PMCID: PMC5237221.

 

12. Han HJ, Wen HL, Zhao L, Liu JW, Luo LM, Zhou CM, Qin XR, Zhu YL, Zheng XX, Yu XJ. Novel Bartonella Species in Insectivorous Bats, Northern China. PLoS One. 2017 Jan 12;12(1):e0167915. doi: 10.1371/journal.pone.0167915. eCollection 2017. PubMed PMID: 28081122; PubMed Central PMCID: PMC5231389.

 

13. Liu Y, Yu X. Identification and Diagnosis of Newly Emerging Pathogens. Infectious Diseases and Translational Medicine. 2017:1.

 

14. Liu MM, Lei XY, Yu XJ. Meta-analysis of the clinical and laboratory parameters of SFTS patients in China. Virol J. 2016;13(1):198. PubMed PMID: 27899121; PubMed Central PMCID: PMC5129669.

 

15. Jiang F, Zhang Z, Dong L, Hao B, Xue Z, Ma D, Su H, Wen HL, Yu H, Yu XJ. Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. Sci Rep. 2016 27;6:36081. doi: 10.1038/srep36081. PubMed PMID: 27786303; PubMed Central PMCID: PMC5081555.

 

16. Huang YT, Zhao L, Wen HL, Yang Y, Yu H, Yu XJ. Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China. Emerg Infect Dis. 2016;22(11):1985-1987. doi: 10.3201/eid2211.160414. PubMed PMID: 27767907; PubMed Central PMCID: PMC5088025.

 

17. Ding SJ, Zhang Y, Zhang XM, Jiang XL, Pang B, Song YH, Wang JX, Pei YW, Zhu CF, Wang XJ, Yu XJ. Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome. PLoS Negl Trop Dis. 2016;10(10):e0005076. doi: 10.1371/journal.pntd.0005076. PubMed PMID: 27760141; PubMed Central PMCID: PMC5070855.

 

18. Liu Y, Yu XJ. Human Granulocytic Anaplasmosis and Lyme Disease--Reply. JAMA. 2016 Jul 5;316(1):99. doi: 10.1001/jama.2016.4295. PubMed PMID: 27380351.

 

19. Luo L, Sun J, Yan J, Wang C, Zhang Z, Zhao L, Han H, Tong Z, Liu M, Wu Y, Wen H, Zhang R, Xue Z, Sun X, Li K, Ma D, Liu J, Huang Y, Ye L, Li W, Jiang J, Yu XJ. Detection of a Novel Ehrlichia Species in Haemaphysalis longicornis Tick from China. Vector Borne Zoonotic Dis. 2016;16(6):363-7. doi:10.1089/vbz.2015.1898. PubMed PMID: 27135624; PubMed CentralPMCID: PMC4884337.

 

20. Luo L, Sun J, Yan J, Wang C, Zhang Z, Zhao L, Han H, Tong Z, Liu M, Wu Y, Wen H, Zhang R, Xue Z, Sun X, Li K, Ma D, Liu J, Huang Y, Ye L, Li W, Jiang J, Yu XJ. Detection of a Novel Ehrlichia Species in Haemaphysalis longicornis Tick from China. Vector Borne Zoonotic Dis. 2016; 16(6):363-7. doi:10.1089/vbz.2015.1898. PubMed PMID: 27135624; PubMed Central PMCID: PMC4884337.

 

21. Liu JW, Zhao L, Luo LM, Liu MM, Sun Y, Su X, Yu XJ. Molecular Evolution and Spatial Transmission of Severe Fever with Thrombocytopenia Syndrome Virus Based on Complete Genome Sequences. PLoS One. 2016;11(3):e0151677. doi:10.1371/journal.pone.0151677. eCollection 2016. PubMed PMID: 26999664; PubMed Central PMCID: PMC4801363.

 

22. Tsai KH, Chang SF, Yen TY, Shih WL, Chen WJ, Wang HC, Yu XJ, Wen TH, Wu WJ, Shu PY. Prevalence of antibodies against Ehrlichia spp. and Orientia tsutsugamushi in small mammals around harbors in Taiwan. Parasit Vectors. 2016;9:45. doi: 10.1186/s13071-016-1318-7. PubMed PMID: 26817445; PubMed Central PMCID: PMC4728797.

 

23. Wang L, Wang T, Cui F, Zhai SY, Zhang L, Yang SX, Wang ZQ, Yu XJ. Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. Emerg Infect Dis. 2016;22(2):274-6. doi: 10.3201eid/2202.151516. PubMed PMID: 26812444; PubMed Central PMCID: PMC4734509.

 

24. Zhuang ZC, Kou ZQ, Bai YJ, Cong X, Wang LH, Li C, Zhao L, Yu XJ, Wang ZY, Wen HL. Epidemiological Research on Hand, Foot, and Mouth Disease in Mainland China.  Viruses. 2015;7(12):6400-11. doi: 10.3390/v7122947. PubMed PMID: 26690202; PubMed Central PMCID: PMC4690870.

 

25. Han HJ, Yu H, Yu XJ. Evidence for zoonotic origins of Middle East respiratory syndrome coronavirus. J Gen Virol. 2016; 97(2):274-80. doi:10.1099/jgv.0.000342. PubMed PMID: 26572912.

 

26. Sun XF, Zhao L, Wen HL, Luo LM, Yu XJ. Anaplasma species in China. Lancet Infect Dis. 2015;15(11):1263-4. doi: 10.1016/S1473-3099(15)00377-1. PubMed PMID: 26531037.

 

27. Luo LM, Zhao L, Wen HL, Zhang ZT, Liu JW, Fang LZ, Xue ZF, Ma DQ, Zhang XS, Ding SJ, Lei XY, Yu XJ. Haemaphysalis longicornis Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China. Emerg Infect Dis. 2015;21(10):1770-6. doi: 10.3201/eid2110.150126. PubMed PMID: 26402039; PubMed Central PMCID: PMC4593435.

 

28. Ma YW, Hao SB, Sun LL, Li J, Qiao Q, Gao F, Zhao L, Yu XJ, Wang ZY, Wen HL. Construction and characterization of infectious cDNA clones of enterovirus 71 (EV71). Virol Sin. 2015;30(4):305-8. doi: 10.1007/s12250-015-3614-3. PubMed PMID: 26271283.

 

29. Han HJ, Wen HL, Zhou CM, Chen FF, Luo LM, Liu JW, Yu XJ. Bats as reservoirs of severe emerging infectious diseases. Virus Res. 2015;205:1-6. doi:10.1016/j.virusres.2015.05.006. PubMed PMID: 25997928.

 

30. Fang LZ, Zhao L, Wen HL, Zhang ZT, Liu JW, He ST, Xue ZF, Ma DQ, Zhang XS, Zhang Y, Yu XJ. Reservoir host expansion of hantavirus, China. Emerg Infect Dis. 2015;21(1):170-1. doi: 10.3201/eid2101.140960. PubMed PMID: 25531113; PubMed Central PMCID: PMC4285249.

 

31. Lei XY, Liu MM, Yu XJ. Severe fever with thrombocytopenia syndrome and its pathogen SFTSV. Microbes Infect. 2015;17(2):149-54. doi: 10.1016/j.micinf.2014.12.002. PubMed PMID: 25498868.

 

32. Liu JW, Wen HL, Fang LZ, Zhang ZT, He ST, Xue ZF, Ma DQ, Zhang XS, Wang T, Yu H, Zhang Y, Zhao L, Yu XJ. Prevalence of SFTSV among Asian house shrews and rodents, China, January-August 2013. Emerg Infect Dis. 2014;20(12):2126-8. doi: 10.3201/eid2012.141013. PubMed PMID: 25418111; PubMed Central PMCID:PMC4257798.

 

33. Liu Y, Wu B, Weinstock G, Walker DH, Yu XJ. Inactivation of SAM-methyltransferase is the mechanism of attenuation of a historic louse borne typhus vaccine strain. PLoS One. 2014;9(11):e113285. doi:10.1371/journal.pone.0113285. eCollection 2014. PubMed PMID: 25412248; PubMed Central PMCID: PMC4239044.

 

34. Ding S, Niu G, Xu X, Li J, Zhang X, Yin H, Zhang N, Jiang X, Wang S, Liang M, Wang X, Yu XJ. Age is a critical risk factor for severe fever with thrombocytopenia syndrome. PLoS One. 2014;9(11):e111736. doi:10.1371/journal.pone.0111736. eCollection 2014. PubMed PMID: 25369237; PubMed Central PMCID: PMC4219771.

 

35. Yu XJ, Tesh RB. The role of mites in the transmission and maintenance of Hantaan virus (Hantavirus: Bunyaviridae). J Infect Dis. 2014;210(11):1693-9. doi: 10.1093/infdis/jiu336. PubMed PMID: 24958909; PubMed Central PMCID: PMC4296190.

 

36. Sun LL, Wang JK, Cui XQ, Hao SB, Li J, Zhao L, Yuan XJ, Wen HL, Yu XJ, Wang ZY. Association of viral replication capacity with the pathogenicity of enterovirus 71. Virus Res. 2014;189:1-7. doi:10.1016/j.virusres.2014.04.014. PubMed PMID: 24792876.

 

37. Zhao L, Pu SS, Gao WH, Chi YY, Wen HL, Wang ZY, Song YY, Yu XJ. Effects of HIV-1 tat on secretion of TNF-α and IL-1β by U87 cells in AIDS patients with or without AIDS dementia complex. Biomed Environ Sci. 2014 Feb;27(2):111-7. doi:10.3967/bes2014.024. PubMed PMID: 24625401.

 

38. Cheng Y, Liu Y, Wu B, Zhang JZ, Gu J, Liao YL, Wang FK, Mao XH, Yu XJ. Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells. PLoS One. 2014 Feb 18;9(2):e88461. doi: 10.1371/journal.pone.0088461. eCollection 2014. PubMed PMID: 24558391; PubMed Central PMCID: PMC3928192.

 

39. Lei X, Wen H, Zhao L, Yu X. Performance of reversed transcription loop-mediated isothermal amplification technique detecting EV71: a systematic review with meta-analysis. Biosci Trends. 2014;8(2):75-83. PubMed PMID: 24815384.

 

40. Santiago FW, Covaleda LM, Sanchez-Aparicio MT, Silvas JA, Diaz-Vizarreta AC, Patel JR, Popov V, Yu XJ, García-Sastre A, Aguilar PV. Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses. J Virol. 2014 Apr;88(8):4572-85. doi: 10.1128/JVI.03021-13. Epub 2014 Jan 29. PubMed PMID: 24478431; PubMed Central PMCID: PMC3993744. 


书籍:Book Chapters 

1. Yu XJ and Walker DH. Epidemiology, Molecular Biology, and Pathogenic Mechanisms of Ehrlichia Infections. In: Rickettsiales Biology, Molecular Biology, Epidemiology, and Vaccine Development. Sunil Thomas Editor, Springer. ISBN 978-3-319-46857-0 ISBN 978-3-319-46859-4 (eBook) DOI 10.1007/978-3-319-46859-4. 2016

2. Yu XJ and Walker DH. Rickettsia and Bioterrorism. In Bioterrorism. Dr. Stephen S. Morse edInTech 2012 ISBN 978-953-307-636-2.

3. Yu XJ and Walker DH. Rickettsia Vaccine.  In: Vaccines against Bacterial Biothreat Pathogens. Vladimir L. Motin Ed.Research Signpost/Transworld Research Network. 2011

4. Yu XJ, Ismail N, and Walker DH. Chapter 56, Rickettsia. In: Vaccines for biodefense and emerging and neglected diseases. Barrett AD and Stanberry LR, eds, Academic Press, 2008, pp 1122 – 1146.

5. Walker DH and Yu XJ. Rickettsia, Orientia, Ehrlichia and Coxiella. In: Greenwood D, Slack RC, Peutherer JF, eds., Medical Microbiology 17th edition, Elsevier Science Ltd., London, UK,   2006.

6. Yu XJ and Walker DH. Family I. Rickettsiaceae Pinkerton 1936, 186AL. In: Bergey’s manual of systematic bacteriology, 2nd edition, Vol. 2. Garrity GM, ed. Springer, New York, 2005.

7. Yu XJ and Walker DH. “The Order Rickettsiales,” In: The Prokaryotes: An evolving electronic resource for the microbiological community, 3rd edition. Dworkin M, Falkow S, Rosenberg E, Schleifer KH, and Stackebrandt E, eds., Springer-Verlag, New York, 2003.

8. Walker DH and Yu XJ. Rickettsia, Orientia, Ehrlichia and Coxiella. In: Greenwood D, Slack RC, Peutherer JF, eds., Medical Microbiology 16th edition, Elsevier Science Ltd., London, UK, pp369-378,  2002.



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