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蓝柯


 

姓名

蓝柯

性别

职务

主任

职称

教授

学历

博士研究生

通讯地址

武汉大学生命科学学院4106室

电话

17317580021

邮编

430072

传真

 

电子邮件

klan@whu.edu.cn 

 


教育经历

1998.09-2001.07      中南大学湘雅医学院,研究生,博士学位

1995.09-1998.06      重庆医科大学,研究生,硕士学位;

1989.09-1994.06      重庆医科大学,本科,学士学位;

 

工作经历

2006.08-2016.12    中国科学院上海巴斯德研究所,研究员,教授,博士生导师,肿瘤病毒研究室负责人,病原诊断中心主任;副所长

2002.06-2006.07    美国宾夕法尼亚大学微生物学系,博士后;

2001.08-2002.05    深圳益生堂生物企业有限公司,研发工程师;

1994.07-1995.08    四川省屏山县人民医院,内科住院医师;

 

学术兼职

《Journal of Virology》编委 (Editorial Board Member)

《Journal of Medical Virology》副主编 (Associate Editor)

《PLoS One》学术编辑 (Academic Editor)

17届国际卡波氏肉瘤病毒大会主席

40届国际疱疹病毒大会学术委员会委员

中国细胞生物学学报编委

美国微生物学会会员

上海生物工程学会常务理事

中国微生物学会病毒专业委员会委员

中国病理生理学会肿瘤专业委员会常务委员

中科院上海生命科学研究院学术委员会委员

 

研究内容

致力于肿瘤病毒感染与致瘤的机制研究,利用具有潜伏特征的卡波氏肉瘤相关疱疹病毒(KSHV)以及慢性持续性感染特征的乙型肝炎病毒(HBV)作为模式病原,深入研究病毒和宿主相互作用及感染致病机制,发展有效的抗病毒治疗策略。


主持项目

1. 国家重点研发计划(基金号:2016YFA0502100)

课题名称: 疱疹病毒感染与致病过程中蛋白质机器的功能机制

执行年限:2017-2021

承担角色:首席科学家

资助金额:32,110,000人民币

2. 法国道达尔基金会国际项目 (基金号:Total2016-4)

课题名称: Development of public health tools for prevention and treatment of

severe hand-foot-mouth disease (HFMD) in children

执行年限:2016-2018

承担角色: 首席科学家

资助金额: 1,450,000 欧元

3. 美国国立卫生研究院R01国际项目 (基金号: 1R01AI116442)

课题名称: Versatile functions of LANA in KSHV pathogenesis

执行年限:2015-2019

承担角色: 主持人

资助金额: 520,000美元

4. 国家杰出青年科学基金项目(基金号:81425017)

课题名称:KSHV潜伏感染与致瘤机制.

执行年限:2015-2019

承担角色:主持人

资助金额:4,000,000人民币

5. 国际(地区)合作与交流项目NSFC-NIH项目(中美)(基金号:81361120394)

课题名称:卡波氏肉瘤相关疱疹病毒(KSHV)基因组在卡波氏肉瘤组织中的表观遗传修饰研究

执行年限:2014-2016

承担角色:主持人

资助金额:1,800,000人民币

6. 国家自然科学基金重点项目(基金号:81230037)

课题名称:卡波氏肉瘤相关疱疹病毒潜伏感染基因表达调控的机制研究

执行年限:2013-2017

承担角色:主持人

资助金额:2,800,000人民币

 

成果

1. Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma. PLoS Pathog. 2017 Sep 28;13(9):e1006580.

2. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y, Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model. Hepatology. 2017 Jul 27. doi: 10.1002/hep.29406.

3. Lin X, Sun R, Zhang F, Gao Y, Bin L, Lan K*. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency. J Virol. 2017 Aug 10;91(17). pii: e00806-17.

4. Zou Z, Meng Z, Ma C, Liang D, Sun R, Lan K*. Guanylate-Binding Protein 1 Inhibits Nuclear Delivery of Kaposi's Sarcoma-Associated Herpesvirus Virions by Disrupting Formation of Actin Filament. J Virol. 2017 Jul 27;91(16). pii: e00632-17.

5. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES, Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues.PLoS Pathog. 2017 Jan 24;13(1):e1006167. doi: 10.1371/journal.ppat.1006167.

6. Li S, Hu H, He Z, Liang D, Sun R, Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct 19;12(10):e1005900.

7. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y, Lan K*. Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor. J Virol. 2015 Nov 4;90(3):1158-68.

8. Jia B, Guo M, Li G, Yu D, Zhang X, Lan K*, Deng Q*. Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7. J Virol. 2015 Feb 15;89(4):2041-51.

9. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 2015 Jan;89(1):415-27

10. Liang D , Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao S, Lan K*. Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis. PLoS Pathog. 2014 Jul 10;10(7):e1004253.

11. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y, Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice. J Virol. 2014 Jul;88(14):8045-56

12. Sun R, Liang D, Gao Y, Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency. J Virol. 2014 Jul 1;88(13):7331-7344.

13. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q, Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus. J Virol. 2014 Jun;88(11):6506-11

14. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1. Cancer Res. 2014 Apr 1;74(7):2026-37.

15. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML, Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection. J Virol. 2014 Mar;88(5):3004-15.

16. Han J, Jin M, Zhang P, Liu J, Wang L, Wen D, Wu X, Liu G, Zou Y, Lv X, Dong X, Shao B, Gu S, Zhou D, Leng Q, Zhang C, Lan K. Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill. 2013 May 16;18(20). pii: 20481.

17. Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K*, Wei Y*.The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia. J Biol Chem. 2013 Jan 18;288(3):1785-94.

18. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, Deng Q, Lan K*, Zhou W*. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell. 2013 Jan;4(1):71-81.

19. Lin X, Li X, Liang D, Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirusvirions. J Virol. 2012 Dec; 86(23): 12717-30.

20. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression. J Virol. 2012 May;86(9):4956-69

21. Liang D, Lin X, Lan K*. Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint. Front Microbiol. 2011;2:271.

22. Liu Y, Sun R, Lin X, Liang D, Deng Q, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5. J Virol. 2012 Feb; 86(3):1372-81.

23. Li X, Liang D, Lin X, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. J Virol. 2011 Sep;85(17):8606-15.

24. Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K*,Wang J*. Penicilliummarneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011;6(11):e27609

25. Lin X, Liang D, He Z, Deng Q, Robertson ES, Lan K*. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20;6(1):e16224.

26. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K*. A human herpesvirusmiRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε. Cell Res. 2011 May;21(5):793-806.

27. He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K*. Cellular corepressor TLE2 inhibits replication-and-transcription-activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb;84(4):2047-62.

28. Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov;8(22):2136-43.

29. Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES, Lan K*. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. Virology. 2008 Oct 25;380(2):264-75.

30. Lan K, Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16287-92.

31. Lan K, Murakami M, Choudhuri T, Tsai DE, Schuster SJ, Wasik MA, and Robertson E. Detection of Epstein-Barr Virus in T-Cell Prolymphocytic Leukemia cells in vitro. J Clin Virol. 2008;43:260-5.

32. Lan K, Choudhuri T, Murakami M, Kuppers DA, and Robertson E. Intracellular Activated Notch1 Is Critical for Proliferation of KSHV Associated B Lymphoma Cell Lines in vitro. J Virol. 2006, 80(13):6411-6419

33. Lan K, Murakami M, Choudhuri T, Kuppers D, and Robertson E. Intracellular Activated Notch1 Can Reactivate KSHV from Latency. Virology. 2006, 351:393-403.

34. Lan K, Kuppers D, Verma S, Sharma N, Murakami M, and Robertson E. Induction of KSHV Latency Associated Nuclear Antigen by the Lytic Transactivator RTA: A Novel Mechanism for Establishment of Latency. J Virol. 2005;79(12):7453-65

35. Lan K, Kuppers D, and Robertson E. KSHV Reactivation is Regulated by Interaction of LANA with RBP-Jk, the Major Downstream Effector of the Notch Signaling Pathway. J Virol. 2005;79(6):3468-78

36. Lan K, Kuppers DA, Verma SC, and Robertson E. Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency. J Virol. 2004;78: 6585-6594


 

奖励

2016国家万人计划领军人才

2016中科院特聘研究员

2015上海市先进工作者(劳模)

2015上海领军人才

2014国家中青年科技创新领军人才 (国家创新人才推进计划)

2014国家杰出青年科学基金获得者

2012药明康德生命化学研究奖

2012上海市黄浦区十大自主创新领军人才称号

2011国务院政府特殊津贴

2011中科院朱李月华优秀教师奖

2010上海市创先争优世博先锋“五带头”优秀共产党员称号

2010明治乳业生命科学奖

2009新世纪百千万人才工程国家级人选

2008上海市浦江人才

2006中国科学院“百人计划”入选者

2006美国白血病和淋巴瘤学会Special Fellow Award