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鄢慧民

 

中文简历

 

姓名

鄢慧民

性别

职务

 

职称

研究员

学历

博士

通讯地址

中国科学院武汉病毒研究所

电话

027-87197103

邮编

430071

传真

027-87197103

电子邮件

hmyan@wh.iov.cn

 

教育经历

1998/09-2002/09:美国凯斯西保留地大学,医学院病理系,病毒免疫,博士后。

1995/09-1998/09:武汉大学,生命科学学院,遗传学,博士。

1982/09-1986/06:武汉大学,生物系,遗传学,学士。

工作经历

2006/07-  至今:中国科学院武汉病毒研究所,病毒学国家重点实验室,研究员。

1998/07-2006/06:武汉大学,生命科学学院,副教授。

1992/07-1998/06:武汉大学,生命科学学院,讲师。

1986/07-1992/06:武汉大学,生物系,助教。

学术兼职

  1.  湖北省微生物学会,理事。

  2. 湖北省免疫学会,理事

     

    研究内容

    主要研究方向为IgA抗体在黏膜免疫防御中的抗病毒功能及其应用研究。包括IgA单克隆抗体和黏膜疫苗的抗病毒免疫预防和治疗;基于细菌鞭毛素蛋白的黏膜佐剂免疫识别机制和应用;黏膜佐剂和黏膜疫苗及其与黏膜上皮细胞的相互作用及黏膜免疫效应。

     

    主持项目

      

    国家自然科学基金面上项目,.国家重点研发计划课题,国家“十一五”“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项课题等。

     

     

    成果

        近5年主要论文

  1. Wei Li, Jingyi Yang, Ejuan Zhang, Maohua Zhong, Yang Xiao, Jie Yu, DihanZhou, Yuan Cao, Yi Yang, Yaoming Li and HuiminYan. Activation of NLRC4 downregulates TLR5-mediated antibody immuneresponses against flagellin. Cell Mol Immunol. 2016, 13:514-523. doi:10.1038/cmi.2015.33

  2. Rong Bao,Jingyi Yang, Ying Sun, Dihan Zhou, Yi Yang, Yaoming Li, Yuan Cao, Yang Xiao, Wei Li, Jie Yu, Bali Zhao, Maohua Zhong, Huimin Yan.Flagellin-PAc Fusion Protein Inhibits Progression of Established Caries. JDent Res. 2015.94: 955-960, firstpublished on April 16, 2015 as doi:10.1177/0022034515582224

  3. Yang Xiao, Fang Liu, Jingyi Yang, Maohua Zhong,Ejuan Zhang, Yaoming Li, Dihan Zhou, Yuan Cao, Wei Li, Jie Yu, Yi Yang and Huimin Yan.Over-activation of TLR5 signaling by high-dose flagellin induces liver injuryin mice. Cell Mol Immunol. 2015.12:730–743

  4. Jingyi Yang, Ejuan Zhang, Fang Liu, Yan Zhang, Maohua Zhong, Yaoming Li,Dihan Zhou, Yaoqing Chen, Yuan Cao, Yang Xiao, Benxia He, Yi Yang, Ying Sun,Mengji Lu, Huimin Yan. Flagellins ofSalmonella Typhi and non-pathogenic Escherichia coli are differentiallyrecognized through NLRC4 pathway in macrophages. Journal of Innate Immunity.2014. 6:47-57

  5. Huimin Yan. SalivaryIgA enhancement strategy for development of a nasal-spray anti-caries mucosalvaccine. Sci China Life Sci. 2013. 56(5):406-413.

  6. Jingyi Yang, Maohua Zhong, Yan Zhang, Ejuan Zhang, Ying Sun, Yuan Cao, YaomingLi, Dihan Zhou, Benxia He, Yaoqing Chen, Yi Yang, Jie Yu, Huimin Yan. Antigen replacement of domains D2 and D3 in flagellinpromotes mucosal IgA production and attenuates flagellin-induced inflammatoryresponse after intranasal immunization. Human Vaccines & Immunotherapeutics,2013. 9(5): 1084-1092.

  7. Ying Sun, Wei Shi , Jingyi Yang, Dihan Zhou, Yaoqing Chen, Yan Zhang, YiYang, Benxia He, Maohua Zhong, Yaoming Li, Yuan Cao, Yang Xiao, Wei Li, Jie Yu,Yuhong Li, Mingwen Fan, Huimin Yan. Flagellin-PAcFusion Protein Is a High Efficacy Anti-caries Mucosal Vaccine. JDent Res. 2012. 91(10): 941-947

  8. Maohua Zhong, Benxia He, Jingyi Yang, Rong Bao, Yan Zhang, Dihan Zhou, YaoqingChen, Liangzhu Li, Chen Han, Yi Yang, Ying Sun, Yuan Cao, Yaoming Li, Wei Shi, ShiboJiang, Xiaoyan Zhang, Huimin Yan.L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammationfor Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide. AntimicrobAgents Chemother, 2012. 56(6):3121-3132

  9. Wei Shi, Yuhong Li, Fang Liu, Jingyi Yang, Dihan Zhou, Yaoqing Chen,Yan Zhang, Yi Yang,Benxia He, Chen Han, Mingwen Fan, HuiminYan. Flagellin enhances saliva IgA response and protection of anti-cariesDNA vaccine. J Dent Res. 2012. 91(3):249-54

  10. Dihan Zhou, Yan Zhang, Qiaoli Li,Yaoqing Chen, Benxia He, Jingyi Yang, Haobo Tu, Lei Lei, and Huimin Yan. Matrix protein-specific IgAantibody inhibits measles virus replication by intracellular neutralization. J.Virol. 2011. 85(21):11090-7.

     

    授权专利

    1.    US8,449,891 B2. Recombinant Flagellin Protein and Preparation and Use Thereof.

    Huimin YAN, Fang LIU, Jingyi YANG. (美国)Date of Patent:May 28, 2013

    2.    ZL200910194284.1 Recombinant Flagellin Protein and Preparation and Use Thereof.(一种改造的鞭毛素蛋白及其制备方法和应用。)China(中国)Huimin YAN, Fang LIU, Jingyi YANG。(鄢慧民,刘芳,杨菁毅)。Date of Patent: July 24, 2013

    3.    ZL200910194285.6. A kind of optimized mucosal adjuvant based on non-pathogenic E.coli-derived flagellin(一种改造的非致病细菌来源的鞭毛素黏膜佐剂及制备方法。)China (中国)Huimin YAN, Jingyi YANG, Fang LIU。(鄢慧民,杨菁毅,刘芳)。Date of Patent: March 13, 2013

    4.    ZL201110062300.9. (评价作用于体内黏膜的药物和外源物安全性的方法和应用。)China (中国)Huimin YAN, Maohua ZHONG, BenxiaHE。(鄢慧民,钟茂华,何本霞)。Date of Patent: September 4, 2013

    5.    ZL201110438088.1. VACCINE FOR DENTAL CARIES AND METHODS FOR PREPARING THE SAME.(龋齿疫苗及制备方法。)China (中国)Huimin YAN, Wei SHI, Ying SUN, Jingyi YANG。(鄢慧民,石伟,孙颖,杨菁毅)。Date of Patent: April 9, 2014

    6.    US9,119,803. VACCINE FOR DENTAL CARIES AND METHODS FOR PREPARING THE SAME. HuiminYAN, Wei SHI, Ying SUN, Jingyi YANG(美国)Date of Patent: September 1, 2015