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陈新文

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姓名

陈新文

性别

职务

所长

职称

研究员

学历

博士

通讯地址

武汉市小洪山中区44号中国科学院武汉病毒研究所307

电话

027-87199106

邮编

430071

传真

027-87199106

电子邮件

chenxw@wh.iov.cn

 

教育经历

2002,美国加洲大学Berkeley分校,联合博士

1997.06-2001.09,荷兰Wageningen大学,病毒系,博士

1986.09—1988.06,河南工业大学,硕士

1982.09-1986.06,华中师范大学,生物系,学士

 

工作经历

2008.09-2018.10,中国科学院武汉病毒研究所,所长

2012.01-2016.12,病毒学国家重点实验室,副主任

2004.03-2008.09,中国科学院武汉病毒研究所,副所长

2003.09-2004.6,中国科学院武汉病毒研究所,所长助理

2002.09-至今,中国科学院武汉病毒研究所,博士生导师

2000.09-至今,中国科学院武汉病毒研究所    研究员

1997.09-2000.06,中国科学院武汉病毒研究所,副研究员

1992.09-1997.06中国科学院武汉病毒研究所,助理研究员

 

 

学术兼职

《Journal of Medical Virology》,主编(Editor)

InterAcademy Partnership,生物安全工作组成员(Biosecurity Working Group)

中国科学院公共安全领域专家组组长

生物安全关键技术研发”重点专项专家组成员

“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项专家组成员

 

研究内容

针对危害人类健康的重要病毒病如乙型肝炎和丙型肝炎开展了乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)的分子流行病学、分子生物学、抗药机理、病毒与宿主(细胞)相互作用等方面的研究,以及动物模型等,揭示病毒致病的分子机理,研制基因工程疫苗,并探索新的诊断及治疗方法。研究杆状病毒侵入哺乳动物细胞的机理、杆状病毒基因组DNA在哺乳动物细胞和实验动物体中的状态及目的基因的表达规律,了解杆状病毒用于基因治疗的安全性和效率,为其奠定应用的基础,同时构建一系列具有自主知识产权杆状病毒载体系统并用于重要疾病的基因治疗。   

 

 

主持项目

1.国家重点研发计划(编号:2018YFA0507200)

项目名称: 高致病性病毒转录复制过程关键蛋白质机器的功能和干预机制

执行年限:  2018-2023

承担角色: 首席科学家

资助金额:  28320000人民币

2.国家重大科学研究计划(编号:2013CB911100)

项目名称:重要病毒转录复制蛋白复合体的结构和功能研究

执行年限:2013-2017

承担角色:首席科学家

资助金额:22030000 人民币

3.国家自然科学基金重点项目(编号:31030027)

项目名称:杆状病毒诱导的核内肌动蛋白聚合的分子机制及其在病毒复制中的功能研究

承担角色:项目负责人

执行年限:2011-2014

资助金额:2100000 人民币

4.院重点部署项目(编号:ZDRW-ZS-2016-4)

项目名称:重要烈性病毒防控关键技术及产品研发

承担角色:项目负责人

执行年限:2016-2018

资助金额:35000000 人民币

 

成果

(近5年主要研究论文)

1.        YaoYY, Yang B, Chen YS, Wang H, Hu X, Zhou Y, Gao XZ, Lu MJ, Niu JQ, Wen Z, Wu CCand Chen XW*. 2019.RNA-Binding Motif Protein 24 (RBM24) Is Involved in Pregenomic RNA Packaging byMediating Interaction between Hepatitis B Virus Polymerase and the EpsilonElement. J Virol 93:e02161-18.

2.        ZhangXW, Xie XP, Zou J, Xia HJ, Shan C, ChenXW* and Shi PY. 2019.Genetic and biochemical characterizations of Zikavirus NS2A protein. Emerg Microbes Infect.8(1): 585-602.

3.        ZhaoKT, Liu SH, Chen YS, Yao YY, Zhou M, Yuan YF, Wang Y, Pei RJ, Chen JZ, Hu X,Zhou Y, Zhao H, Lu MJ, Wu CC and ChenXW*. 2018. Upregulation of HBV Transcription by Sodium TaurocholateCotransporting Polypeptide at the Postentry Step Is Inhibited by the EntryInhibitor Myrcludex B. Emerg Microbes Infect. (7)186:1-14.

4.        GaoXX, Chen D, Hu X, Zhou Y, Wang Y, Wu CC, Chen JZ, Pei RJ and Chen XW*. 2018. PLA1AParticipates in the Antiviral Innate Immune Response by Facilitating theRecruitment of TANK-Binding Kinase 1 to Mitochondria. J Innate Immun10(4):315-327.

5.        DengL, Cao L, Chen YS, Hu X, Chen XW*,Wu CC and Zhou Y. 2018. Hepatitis B surface antigen with N-terminal addition ofmCherry can assemble into functional subviral particles. Future Virology.(13):11.

6.        ZhouY, Wang Q, Yang Q, Tang JL, Xu CH, Gai DW, ChenXW* and Chen JZ. 2018. Histone deacetylase 3 inhibitor suppresseshepatitis C virus replication by regulating Apo-A1 and LEAP-1 expression. VirolSin. (33): pp 418–428.

7.        Cao H,Zhao KT, Yao YY, Guo J, Gao XX, Yang Q, Guo M, Zhu WD, Wang Y, Wu CC, Chen JZ,Zhou Y, Hu X, Lu MJ, Chen XW*and Pei RJ. 2018. RNA binding protein 24 regulates the translation andreplication of hepatitis C virus. Protein Cell.(9):pp 930–944.

8.        YangQ, Tang JL, Pei RJ, Gao XX, Guo J, Xu CH, Wang Y, Wang Q, Wu CC, Zhou Y, Hu X,Zhao H, Wang YY, Chen XW*,Chen JZ. 2018. Host HDAC4 Regulates the Antiviral Response by Inhibiting thePhosphorylation of IRF3. J Mol Cell Biol. (11)2: 158–169.

9.        YaoYY, Yang B, Cao H, Zhao KT, Yuan YF, Chen YS, Zhang ZH, Wang Y, Pei RJ, ChenJZ, Hu X, Zhou Y, Lu MJ Wu CC and ChenXW*. 2018. RBM24 stabilizes hepatitis B virus pregenomic RNA butinhibits core protein translation by targeting the terminal redundancysequence. Emerg Microbes Infect. 7(1):86.

10.      Zhang YL, Hu X, Mu JF, Hu YY, Zhou Y, ZhaoH, Wu CC, Pei RJ, Chen JZ, , Chen XW*and Wang Y. 2018. Ac102 Participates in Nuclear Actin Polymerization byModulating BV/ODV-C42 Ubiquitination during Autographa californica MultipleNucleopolyhedrovirus Infection.JVirol. (92)12:e00005-18.

11.      Guo J, Chen D, Gao XX, Hu X, Zhou Y, Wu CC,Wang Y, Chen CJ, Pei RJ, Chen XW*.2017. Protein Inhibitor of Activated STAT2 Restricts HCV Replication byModulating Viral Proteins Degradation. Viruses 9(10): 285.

12.      Zhao KT, Wu CC, Yao YY, Cao L, Zhang ZH,Yuan YF, Wang Y, Pei RJ, Chen JZ, Hu X, Zhou Y, Lu MJ and Chen XW*. 2017. Ceruloplasmin inhibits the production ofextracellular hepatitis B virions by targeting its middle surface protein.J GEN VIROL 98:1410–1421.

13.      Su X, Liu SH, Zhang XW, Lam MS, Hu X, ZhouY, Chen JZ, Wang Y, Wu CC, Shui GH, Lu MJ, Pei RJ, Chen XW*. 2017. Requirement of Cytosolic Phospholipase A2gamma in Lipid Droplet Formation. BBA Mol Cell Biol L .(1862):692–705.

14.      Liu SH, Zhao KT, Su X, Lu L, Zhao H, ZhangX, Wang Y, Wu C, Chen J, Zhou Y, Hu X, Wang YY, Lu MJ, Chen XW*, Pei RJ. 2017. MITA/STING and Its AlternativeSplicing Isoform MRP Restrict Hepatitis B Virus Replication. PLoS One 12(1).

15.      Mu JF, Zhang YL, Hu YY, Hu X, Zhou Y, Chen XW* and Wang Y. 2017. Therole of viral protein Ac34 in nuclear relocation of subunits of theactin-related protein 2/3 complex.Virol Sin. 31 (6): 480–489.

16.      Mu JF, Zhang YL, Hu YY, Hu X, Zhou Y, ZhaoH, Pei RJ, Wu CC, Chen JZ, Zhao H, Yang K, van Oers MM, Chen XW*, Wang Y. 2016. Autographa californica MultipleNucleopolyhedrovirus Ac34 Protein Retains Cellular Actin-Related Protein 2/3Complex in the Nucleus by Subversion of CRM1-Dependent Nuclear Export. PLOSPathog 12(11):e1005994.

17.      Chen JZ, Wang N, Dong M, Guo M, Zhao Y,Zhuo ZY, Zhang C, Chi XM, Pan Y, Jiang J, Tang H, Niu JQ, Yang DL, Li Z, Han X,Wang Q, Chen XW*. 2015. TheMetabolic Regulator Histone Deacetylase 9 Contributes to Glucose HomeostasisAbnormality Induced by Hepatitis C Virus Infection. Diabetes 64(12):4088-4098.9

18.      Li SX, Zhao KT, Liu SH, Wu CC, Yao YX, CaoL, Hu X, Zhou Y, Wang Y, Pei RJ, Lu MJ, ChenXW*. 2015. HBsAg sT123N mutation induces stronger antibody responses toHBsAg and HBcAg and accelerates in vivo HBsAg clearance. Virus Res 210:119-125.

19.      Wang Y, Zhang YL, Han SL, Hu X, Zhou Y, MuJF, Pei RJ, Wu CC, Chen XW*.2015. Identification of a Novel Regulatory Sequence of Actin NucleationPromoting Factor Encoded by Autographacalifornica Multiple Nucleopolyhedrovirus. J Biol Chem .290: 9533-9541.

20.      Li HD, Zhu WD, Zhang LK, Lei HH, Wu XY, GuoL, Chen XW*, Wang YL, TangHR. 2015. The metabolic responses to hepatitis B virus infection shed new lighton pathogenesis and targets for treatment. Sci Rep 5: 8421.

21.      Guo M, Pei RJ, Yang Q, Cao H, Wang Y, WuCC, Chen JZ, Zhou Y, Hu X, Lu MJ, ChenXW*. 2015. Phosphatidylserine-Specific Phospholipase A1 is involved inHepatitis C Virus Assembly through NS2 Complex Formation. J Virol.89(4):2367-77 (80)

22.      Liang CY, Lan DD, Zhao SL, Liu LL, Xue YN,Zhang YL, Wang Y, Chen XW*.2015. The Ac124 protein is not essential for the propagation of Autographacalifornica multiple nucleopolyhedrovirus, but it is a viral pathogenicityfactor. Arch Virol .160(1):275-8. (79)

23.      Chen YZ, Wang SS, Yi ZH, Tian HB, AliyariR, Li YH, Chen G, Liu P, Zhong J,Chen XW*, Du PS, Su LS, Qin FX, Deng HY, Cheng GH. 2014.Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C VirusReplication via Distinct Mechanisms. Sci Rep 4: 7242. doi: 10.1038/srep07242.

24.      Mu JF, van Lent JW, Smagghe G, Wang Y, Chen XW*, Vlak JM, van Oers MM.2014. Live imaging of baculovirus infection of midgut epithelium cells: afunctional assay of per os infectivity factors. J Gen Virol. 95: 2531-2539.

25.      Pei RJ, Chen XW*, Lu MJ. 2014. Control of hepatitis B virusreplication by interferons and Toll-like receptor signaling pathways. World JGastroenterol .20(33):11618-11629.

26.      Chen JZ, Zhao Y, Zhang C, Chen HR, Feng J,Chi XM, Pan Y, Du J, Guo, M, Cao H, Chen HH, Wang ZL, Pei RJ, Wang Q, Pan L,Niu JQ, Chen XW*, Tang H.2014. Persistent hepatitis C virus infections and hepatopathologicalmanifestations in immune-competent humanized mice. Cell Res .24:1050–1066.

27.      Pei RJ, Grund S, Verheyen J, Esser S, Chen XW*, Lu MJ. 2014. Spontaneousreactivation of hepatitis B virus replication in an HIV coinfected patient withisolated anti-Hepatitis B core antibodies. Virol J .(11): 9.

28.      Deng A, Chen C, Ishizaka Y, Chen XW*, Sun BL, Yang RG. 2014.Human immunodeficiency virus type 1 Vpr increases hepatitis C virus RNAreplication in cell culture. Virus Res 184:93-102.

29.      Wang ML, Wang J, Yin FF, Tan Y, Deng F, Chen XW*, A. Jehle J, Vlak JM,Hu ZH, Wang HL. 2014. Unraveling the entry mechanism of baculoviruses andevolutionary implications.  J Virol88(4): 2301-2311.

30.      Cao L, Wu CC, Shi H, Gong ZJ, Zhang EJ,Wang H, Zhao KT, Liu SH, Li SX, Gao XZ, Wang Y, Pei RJ, Lu MJ, Chen XW*. 2014. Coexistence ofhepatitis B virus quasispecies enhances viral replication and the ability toinduce host antibody and cellular immune responses. J Virol .88(15): 8656-66.

31.      Zhu WD, Pei RJ, Jin R, Hu X, Zhou Y, WangY, Wu CC, Lu MJ, Chen XW*.2014. Nuclear Receptor 4 group A member 1 determines the hepatitis C virusentry efficiency through the regulation of cellular receptor and apolipoproteinE expression. J Gen Virol .95: 1510-1521.

32.      Liu CH, Chen XW*. 2014. A potential cellular host factor homologousto ZNF-136 can interact with truncated nonstructural protein 2 of hepatitis Cvirus. Arch Virol .159(4): 785-789

33.      Pei RJ, Qin B, Zhang XY, Zhu Wandi, KemperT, Ma ZY, Trippler M, Schlaak J, ChenXW*, Lu MJ. 2014. Interferon-Induced Proteins with TetratricopeptideRepeats 1 and 2 Are Cellular Factors That Limit Hepatitis B Virus Replication.J Innate Immun 6:182-191

34.      Chen HH, Pei RJ, Zhu WD, Zeng R, Wang Y,Wang YY, Lu MJ, Chen XW*.2014. An Alternative Splicing Isoform of MITA Antagonizes MITA-MediatedInduction of Type I IFNs. J Immunol 192(3): 1162-70.

35.     Cao H, Zhu WD, Han QX, Pei RJ, Chen XW*. 2014. Construction of a chimeric hepatitis C virusreplicon based on a strain isolated from a chronic hepatitis C patient. VirolSin 29(1):61-70.

 

 

奖励

2016年:陈新文,中国科学院,特聘研究员;

2011年,.胡志红、陈新文、王华林、孙修炼、邓菲,杆状病毒的功能基因组学及感染机理研究,湖北省人民政府,湖北省自然科学奖,一等奖;

2005年:陈新文,卵寄生蜂传递病毒防治害虫新技术,国家科技部,国家技术发明奖,二等奖;

2004年:陈新文,国家杰出青年科学基金获得者。

2004年:陈新文,中国棉铃虫重组病毒,湖北省人民政府,湖北省科学技术发明奖,三等奖;

2003年:.陈新文,卵寄生蜂传递病毒防治害虫新技术,武汉市人民政府,科技进步奖,一等奖;

2002年,陈新文,政府特殊津贴;

2001年:陈新文,杆状病毒的分子生物学及分子进化研究,湖北省人民政府,自然科学奖,二等奖。

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