教育经历

2006-2008 美国麻省理工学院生物工程系  访问博士生

2003-2008 上海交通大学生命科技学院 硕博连读

1999-2003 山东大学生命科学院 本科

工作经历

2011-至今 武汉大学药学院 教授

2008-2011 美国麻省理工学院生物工程系  博士后

获奖情况

2018年 武汉大学朱裕璧医学奖

2016年 武汉大学医学突出贡献奖

2015年 中组部青年拔尖人才计划

2015年 高等学校科学研究优秀成果奖自然科学一等奖

2014年 武汉大学医学突出贡献奖

2012年 国家基金委优秀青年基金
2011年 教育部新世纪优秀人才
2010年 全国百篇优秀博士论文 

2009年 美国《Bioanalysis》Young Investigator
2009年 上海市优秀博士论文 

2007年 《环球科学》十大科学新闻
2007年 明治乳业生命科学奖

研究内容

1. DNA 表观遗传修饰对生命活动的影响（Impact of DNA phosphorothioate modification on bacterial and archaeal physiology）

2. 表观遗传修饰的生物医学应用（Epigenetic and biomedical applications）

3. 抵抗噬菌体污染的合成生物学底盘(Anti-phage bacterial chassis)

主持项目

1. 主持国家基金委优秀青年基金

2. 主持国家基金委重点国际合作项目

3. 973课题组长

4. 主持中组部青年拔尖人才专项基金

5. 主持科技部合成生物学重点研发计划子课题

6. 主持国家自然科学基金面上项目两项

7. 主持全国优秀博士论文专项基金

8. 主持教育部新世纪优秀人才专项基金

9. 主持湖北省自然科学基金

成果

1. Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang*. SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Nature Microbiology, 2020, July, 5: 917-928. DOI: 10.1038/s41564-020-0700-6.  

2. Xiaolin Wu, Bo Cao, Patricia Aquino, Tsu-Pei Chiu, Chao Chen, Susu Jiang , Zixin Deng, Shi Chen , Remo Rohs, Lianrong Wang*, James E Galagan*, Peter C Dedon*. Epigenetic Competition Reveals Density-Dependent Regulation and Target Site Plasticity of Phosphorothioate Epigenetics in Bacteria. Proc Natl Acad Sci U S A. 2020, June, 117 (25):14322-14330. DOI: 10.1073/pnas.2002933117.

3. Cao B , Chen C , DeMott M , Cheng Q , Clark T, Xiong X, Zheng X, Butty V , Levine S, Yuan G, Boitano M, Luong K, Song Y, Deng Z, Zhou X, Turner S, Korlach K, You D*, Wang L*, Chen S*, Dedon P. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 2014, 5:3951.

4. Yue Wei, Qinqin Huang, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Zixin Deng, Zhiqiang Li, Shi Chen, and Lianrong Wang*, Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics. Nucleic Acids Research, 2021, doi: 10.1093/nar/gkab169.

5. Shiwei Wang, Mengping Wan, Ruolin Huang,a Yujing Zhang, Yuqing Xie, YueWei, Mustafa Ahmad, Dan Wu, Yue Hong, Zixin Deng, Shi Chen, Zhiqiang Li, Lianrong Wang*. SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System. mBio, 2021, 12(2) e00613-21, DOI:10.1128/mBio. 00613-21.

6. Cheng Zhang, Pengqing Nie, Chunliu Zhou, Yue Hu, Suling Duan, Meijia Gu, Dongxu Jiang, YunfuWang. Zixin Deng, Jincao Chen, Shi Chen and Lianrong Wang*. Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner. Cell Death and Disease, 2021 12:209. Doi.org/10.1038/s41419-021-03484-3.

7. Liqiong Liu, Susu Jiang, Mai Xing, Chao Chen, Chongde Lai, Na Li, Guangfeng Liu, Dan Wu, Haiyan Gao, Liang Hong, Pan Wu, Shi Chen, Zixin Deng, Geng Wu, Lianrong Wang*. Structure of a L-cysteine desulfurase from a Ssp DNA phosphorothioation system in Vibrio cyclitrophicus. mBio, 2020, 11(2), DOI:10.1128/mBio.00488-20.

8. Nie P, Li Z, Wang Y, Zhang Y, Zhao M, Luo J, Du S, Deng Z, Chen J, Wang Y, Chen S, Wang L*. Gut microbiome interventions in human health and diseases. Medicinal Research Reviews, 2019 Apr 17. doi: 10.1002/med.21584.

9. Li Y, Liu J, Wang Y, Chan H, Wang L*, Chan W*. Mass Spectrometric and Spectrophotometric Analyses Reveal an Alternative Structure and a New Formation Mechanism for Melanin. Analytical Chemistry, 2015, 87, 7958−7963.

10. Wang L, Jiang S, Chen C, He W, Wu X, Wang F, Tong T, Zou X, Li Z, Luo J, Deng Z, Chen S. Synthetic genomes: from DNA synthesis to genome design. Angew Chem Int Ed., 2018, 57: 2~11.

11. Wang L, Jiang S, Deng Z, Dedon P, Chen S. DNA phosphorothioate modification–a new multi-functional epigenetic system in bacteria. FEMS Microbiology Reviews, 2019, 43(2), 109-122.

12. Chen C, Wang L, Chen S, Wu X, Gu M, Chen X, Jiang S, Wang Y, Deng Z, Dedon P, Chen S. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, doi: 10.1073/pnas.1702450114.

13. Wang L, Chen S, Xu T, Taghizadeh K, Wishnok JS, Zhou X, Deng Z, Dedon PC. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 2007, 3(11):709-10.

14. Wang L, Chen S, Vergin KL, Giovannoni Sj. Chan SW, Demott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci USA. 2011, 108(7):2963-8.

15. Tong T, Chen S, Wang L, Tang Y, Ryu JY, Jiang S, Wu X, Chao Chen C, Luo J, Deng Z, Li Z, Lee SY*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018, doi:10.1073/pnas.1721916115.

16. Gu M, Zixuan Zeng, Xing M, Xiong Y, Deng Z, Chen S, Wang L*. The Biological Applications of Two Aggregation-induced Emission Luminogens. Biotechnology Journal, 2019, 14, 1900212.

17. Wang F, Wang L, Zou X., Duan S., Li Z., Deng Z., Luo J., Lee S. Y.*, Chen S*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances, 2019, doi.org/10.1016/j.biotechadv.2019.03.016.

18. Wu S, Wang L, Gan R, Tong T, Bian H, Li Z, Du S, Deng Z, Chen S. Signature arsenic detoxification pathways in Halomonas sp. GFAJ-1, mBio, 2018, May 1; 9 (3): e00515-18. doi: 10.1128/mBio.00515-18.

19. Zou X, Wang L, Li Z, Luo J, Wang Y, Deng Z, Du S, Chen S. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2017, online March 15^th.

20. Gan R, Wu X, He W, Liu Z, Wu S, Chen C, Chen S, Xiang Q, Deng Z, Liang D, Chen S*, Wang L*. DNA phosphorothioate modifications influence the global transcriptional response and protect DNA from double-stranded breaks. Scientific Reports. 2014 Oct 16;4:6642.

21. Wang L, Chen S, Xiao X, Huang X, You D, Zhou X, Deng Z. arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. Strain FR-008. Applied and Environmental Microbiology. 2006, 72(5):3738-42.

22. Wang L., Chen S., Deng Z. Phosphorothioation: an unusual post-replicative modification on the DNA backbone. Book Chapter. DNA replication. 2011.